Genetics Exam test questions and
answers graded A+
Molecule X interacts with a DNA binding protein, causing the protein to bind to DNA and down-
regulate gene expression. Molecule X is a: - ANS✅✅Co-represser
The lac operon contains how many promoters? - ANS✅✅1
Which of the following sites would be a target of a TRANSLATIONAL REPRESSOR? - ANS✅✅Shine-
Delgarno sequence
The inducer molecule for the lac activator protein is: - ANS✅✅cAMP
What would be the result if the trp codons in region 1 of the trp leader sequence were missing? -
ANS✅✅Transcription would always attenuate
Which of the following circumstances would favor binding of CAP protein and the lac repressor to
DNA? - ANS✅✅Low glucose, low lactose
A protein that covers and hides the intron/exon boundary site is: - ANS✅✅splicing repressor
Which of the following protects turtles from apoxia (absence of oxygen)? - ANS✅✅APOLD1
Which of the following would NOT occur if an insulator were removed from DNA? -
ANS✅✅Regulatory transcription factors would bind to the wrong enhancer or silence
Which transcription factor is the most likely to bind to the following sequence (the underlined
nucleotides are binding sites for the alpha-helix of the transcription factor(s)) - ANS✅✅Leucine
zipper homodimer
DNA undergoes a mutation in a region adjacent to a housekeeping gene. The mutation causes the
entire housekeeping gene to undergo chromatin remodeling to a heterochromatin state. The
mutation event likely altered a - ANS✅✅Insulator
, Downregulation of the glucocorticoid receptor leads to: - ANS✅✅Individuals who are less tolerant
to stress
Which of the following would have the highest levels of gene expression? - ANS✅✅HAT activity on
a promoter
The inactive X chromosome would contain which histone variant? - ANS✅✅MacroH2A
In the gene Igf2, the DNA sequence that controls the imprinting pattern is_______________ on the
maternal allele - ANS✅✅Unmethylated
The age at which a disease appears in an organism is called the... - ANS✅✅age of onset
Which of the following would indicate that a disease has a genetic, rather than an environmental
cause? - ANS✅✅The disease does not occur in individuals exposed to a similar environment
In a disease that is caused by a single gene, the concordance among identical twins should be... -
ANS✅✅100%
Which of the following would indicate that a disease is environmental, rather than a genetic cause? -
ANS✅✅Different populations have the same frequency of the disease
Housekeeping Genes - ANS✅✅Constitutively expressed
Maintain basic cell functions and are Unregulated
Regulated Genes - ANS✅✅Levels dependent on need
Expressed when needed
Silenced when not needed
Transcriptional Activators - ANS✅✅Increase expression
Inducers - up regulate gene expression and activate activators
Inhibitors - down regulate gene expression and inhibit activators
answers graded A+
Molecule X interacts with a DNA binding protein, causing the protein to bind to DNA and down-
regulate gene expression. Molecule X is a: - ANS✅✅Co-represser
The lac operon contains how many promoters? - ANS✅✅1
Which of the following sites would be a target of a TRANSLATIONAL REPRESSOR? - ANS✅✅Shine-
Delgarno sequence
The inducer molecule for the lac activator protein is: - ANS✅✅cAMP
What would be the result if the trp codons in region 1 of the trp leader sequence were missing? -
ANS✅✅Transcription would always attenuate
Which of the following circumstances would favor binding of CAP protein and the lac repressor to
DNA? - ANS✅✅Low glucose, low lactose
A protein that covers and hides the intron/exon boundary site is: - ANS✅✅splicing repressor
Which of the following protects turtles from apoxia (absence of oxygen)? - ANS✅✅APOLD1
Which of the following would NOT occur if an insulator were removed from DNA? -
ANS✅✅Regulatory transcription factors would bind to the wrong enhancer or silence
Which transcription factor is the most likely to bind to the following sequence (the underlined
nucleotides are binding sites for the alpha-helix of the transcription factor(s)) - ANS✅✅Leucine
zipper homodimer
DNA undergoes a mutation in a region adjacent to a housekeeping gene. The mutation causes the
entire housekeeping gene to undergo chromatin remodeling to a heterochromatin state. The
mutation event likely altered a - ANS✅✅Insulator
, Downregulation of the glucocorticoid receptor leads to: - ANS✅✅Individuals who are less tolerant
to stress
Which of the following would have the highest levels of gene expression? - ANS✅✅HAT activity on
a promoter
The inactive X chromosome would contain which histone variant? - ANS✅✅MacroH2A
In the gene Igf2, the DNA sequence that controls the imprinting pattern is_______________ on the
maternal allele - ANS✅✅Unmethylated
The age at which a disease appears in an organism is called the... - ANS✅✅age of onset
Which of the following would indicate that a disease has a genetic, rather than an environmental
cause? - ANS✅✅The disease does not occur in individuals exposed to a similar environment
In a disease that is caused by a single gene, the concordance among identical twins should be... -
ANS✅✅100%
Which of the following would indicate that a disease is environmental, rather than a genetic cause? -
ANS✅✅Different populations have the same frequency of the disease
Housekeeping Genes - ANS✅✅Constitutively expressed
Maintain basic cell functions and are Unregulated
Regulated Genes - ANS✅✅Levels dependent on need
Expressed when needed
Silenced when not needed
Transcriptional Activators - ANS✅✅Increase expression
Inducers - up regulate gene expression and activate activators
Inhibitors - down regulate gene expression and inhibit activators
