Nagelhout Pharm 2 Exam 1 / Nagelhout
Pharmacology II Exam 1 | Comprehensive
Study Guide & Key Concepts
Ultra short acting depolarizer - ---✔✔✔ANSWER----Succinylcholine
Short-Acting non-depolarizer - ---✔✔✔ANSWER----NONE
Intermediate acting non-depolarizer - ---✔✔✔ANSWER-----Atracurium
-Cisatracurium
-Vecuronium
-Rocuronium
,Long acting non-depolarizer - ---✔✔✔ANSWER-----Pancuronium
Agents used to treat alzheimers - ---✔✔✔ANSWER-----Donepezil (Aricept)
-Rivastigmine (Exelon)
-Galantamine (Razadyne)
-Tacrine (Cognex)
How do alzheimer's drugs work? - ---✔✔✔ANSWER----They are
cholinesterase inhibitors. More acetylcholine availability, patient more
alert/aware.
What is important to know about alzheimer's drugs and anesthetic? - ---
✔✔✔ANSWER----Succinylcholine effects may last longer. Inability to
appropriately breakdown excess acetylcholine.
Single twitch monitoring test - ---✔✔✔ANSWER-----A single electrical
stimulus ranging from 0.1-1.0 Hz.
*Requires baseline before drug administration; generally used as qualitative
rather than quantitative assessment.*
Train-of-four test? Useful during? Not used with? - ---✔✔✔ANSWER----A
series of four twitches at 2Hz. Every half second for two seconds.
, *Reflects blockade from 70-100%;
useful during onset, maintenance and emergence.
Administration of Succs
Double-burst test - ---✔✔✔ANSWER----Two short bursts of 50Hz tetanus
seperated by 0.75 seconds.
*Similar to TOF; useful during onset, maintenance, and emergence; may be easier
to detect fade than with TOF; tactile evaluation.*
Tetanus test - ---✔✔✔ANSWER----Generally, consists of rapid delivery of a
30, 50, or 100 Hz stimulus for 5 seconds.
*Should be used sparingly for deep block assessment, painful.*
Posttetanic count? Parameters? - ---✔✔✔ANSWER----50-Hz. Tetanus for 5
seconds, a 3 second pause, then single twitches of 1Hz.
*Used only when TOF or double burst stimulation response is absent; count less
than eight indicates a deep block, and prolonged recovery is likely.*
Pharmacology II Exam 1 | Comprehensive
Study Guide & Key Concepts
Ultra short acting depolarizer - ---✔✔✔ANSWER----Succinylcholine
Short-Acting non-depolarizer - ---✔✔✔ANSWER----NONE
Intermediate acting non-depolarizer - ---✔✔✔ANSWER-----Atracurium
-Cisatracurium
-Vecuronium
-Rocuronium
,Long acting non-depolarizer - ---✔✔✔ANSWER-----Pancuronium
Agents used to treat alzheimers - ---✔✔✔ANSWER-----Donepezil (Aricept)
-Rivastigmine (Exelon)
-Galantamine (Razadyne)
-Tacrine (Cognex)
How do alzheimer's drugs work? - ---✔✔✔ANSWER----They are
cholinesterase inhibitors. More acetylcholine availability, patient more
alert/aware.
What is important to know about alzheimer's drugs and anesthetic? - ---
✔✔✔ANSWER----Succinylcholine effects may last longer. Inability to
appropriately breakdown excess acetylcholine.
Single twitch monitoring test - ---✔✔✔ANSWER-----A single electrical
stimulus ranging from 0.1-1.0 Hz.
*Requires baseline before drug administration; generally used as qualitative
rather than quantitative assessment.*
Train-of-four test? Useful during? Not used with? - ---✔✔✔ANSWER----A
series of four twitches at 2Hz. Every half second for two seconds.
, *Reflects blockade from 70-100%;
useful during onset, maintenance and emergence.
Administration of Succs
Double-burst test - ---✔✔✔ANSWER----Two short bursts of 50Hz tetanus
seperated by 0.75 seconds.
*Similar to TOF; useful during onset, maintenance, and emergence; may be easier
to detect fade than with TOF; tactile evaluation.*
Tetanus test - ---✔✔✔ANSWER----Generally, consists of rapid delivery of a
30, 50, or 100 Hz stimulus for 5 seconds.
*Should be used sparingly for deep block assessment, painful.*
Posttetanic count? Parameters? - ---✔✔✔ANSWER----50-Hz. Tetanus for 5
seconds, a 3 second pause, then single twitches of 1Hz.
*Used only when TOF or double burst stimulation response is absent; count less
than eight indicates a deep block, and prolonged recovery is likely.*
