Molecular Biology Exam test quiz
and answers graded A+
In the 1944 experiment by Avery et al., only ___ was able to transform a nonvirulent strain of
bacteria into a virulent one, thereby demonstration that it is likely the ___.
A) protein; chromosomal material
B) genetics; protein material
C) amino acid; DNA material
D) DNA; genetic material - ANS✅✅D) DNA; genetic material
Hershey and Chase (1952) blender experiment demonstrated that
A) protein is not required for virus production
B) viral coat proteins can enter the infected bacterial cells
C) Reverse transcription is important for viral infection
D) DNA carries the genetic information for viral reproduction - ANS✅✅D) DNA carries the genetic
information for viral reproduction
If a DNA fragment contains 42 base pairs, which of the following is true?
A) the DNA length is 3.8 nm
B) DNA has 84 hydrogen bonds
C) the DNA has four minor grooves and four major grooves
D) the diameter of the DNA is 22 angstroms - ANS✅✅C) the DNA has four minor grooves and four
major grooves
In a piece of DNA which of the following is true?
A) A+T = G+C
B) A+G = C+T
C) A=C
D) Both A and B - ANS✅✅B) A+G = T+C
Which of the following statements is false?
A) the two strands of a DNA helix are identical in sequence
, B) the two strands of a DNA helix are identical in base numbers
C) the two strands of a DNA helix are identical in length
D) the two strands of a DNA helix are identical in hydrogen bond numbers - ANS✅✅A) the two
strands of a DNA helix are identical in sequence
The following proportions exist in DNA: C=G, A=T
A) Yes, this is Chargaff's Rule
B) No, it is A=C, G=T
C) False, C>G, A>T
D) None of the above are correct - ANS✅✅A) Yes this is Chargaff's Rule
H2A and H3 histones in humans
A) both contain N-terminal tails that can be chemically modified
B) are small and rich in arginines and lysines
C) are very similar in amino acid sequence to H2A and H3 in horses
D) all of the above - ANS✅✅D) all of the above
The most common DNA binding domain found in proteins is the
A) helix-turn-helix
B) dimerization domains
C) beta-sheet
D) CAP domain - ANS✅✅A) helix-turn-helix
Which of the following statements are true with regard to protein-DNA interactions?
A) sequence specific interactions occur between the protein and the phosphates in the DNA
backbone
B) histone proteins interact primarily with the nitrogenous bases of DNA
C) Amino acid side chains interact directly with hydrogen donors and other chemical groups in the
major grooves of DNA
D) Glue, lots of glue - ANS✅✅C) Amino acid side chains interact directly with hydrogen donors and
other chemical groups in the major grooves of DNA
and answers graded A+
In the 1944 experiment by Avery et al., only ___ was able to transform a nonvirulent strain of
bacteria into a virulent one, thereby demonstration that it is likely the ___.
A) protein; chromosomal material
B) genetics; protein material
C) amino acid; DNA material
D) DNA; genetic material - ANS✅✅D) DNA; genetic material
Hershey and Chase (1952) blender experiment demonstrated that
A) protein is not required for virus production
B) viral coat proteins can enter the infected bacterial cells
C) Reverse transcription is important for viral infection
D) DNA carries the genetic information for viral reproduction - ANS✅✅D) DNA carries the genetic
information for viral reproduction
If a DNA fragment contains 42 base pairs, which of the following is true?
A) the DNA length is 3.8 nm
B) DNA has 84 hydrogen bonds
C) the DNA has four minor grooves and four major grooves
D) the diameter of the DNA is 22 angstroms - ANS✅✅C) the DNA has four minor grooves and four
major grooves
In a piece of DNA which of the following is true?
A) A+T = G+C
B) A+G = C+T
C) A=C
D) Both A and B - ANS✅✅B) A+G = T+C
Which of the following statements is false?
A) the two strands of a DNA helix are identical in sequence
, B) the two strands of a DNA helix are identical in base numbers
C) the two strands of a DNA helix are identical in length
D) the two strands of a DNA helix are identical in hydrogen bond numbers - ANS✅✅A) the two
strands of a DNA helix are identical in sequence
The following proportions exist in DNA: C=G, A=T
A) Yes, this is Chargaff's Rule
B) No, it is A=C, G=T
C) False, C>G, A>T
D) None of the above are correct - ANS✅✅A) Yes this is Chargaff's Rule
H2A and H3 histones in humans
A) both contain N-terminal tails that can be chemically modified
B) are small and rich in arginines and lysines
C) are very similar in amino acid sequence to H2A and H3 in horses
D) all of the above - ANS✅✅D) all of the above
The most common DNA binding domain found in proteins is the
A) helix-turn-helix
B) dimerization domains
C) beta-sheet
D) CAP domain - ANS✅✅A) helix-turn-helix
Which of the following statements are true with regard to protein-DNA interactions?
A) sequence specific interactions occur between the protein and the phosphates in the DNA
backbone
B) histone proteins interact primarily with the nitrogenous bases of DNA
C) Amino acid side chains interact directly with hydrogen donors and other chemical groups in the
major grooves of DNA
D) Glue, lots of glue - ANS✅✅C) Amino acid side chains interact directly with hydrogen donors and
other chemical groups in the major grooves of DNA
