ASCP CGMBS Exam Study ACTUAL
QUESTIONS AND CORRECT ANSWERS
BCR;ABL1 fusion protein - CORRECT ANSWERS✅✅t(9;22)(q34;q11)
Acute Promyelocytic Leukemia (APL) - CORRECT ANSWERS✅✅t(15;17) a fusion of
PML and RARA
Burkitt's Lymphoma - CORRECT ANSWERS✅✅t(8;14) the breakpoints on chr.8 are
spread of 190 kbp region 5' to and within the C-MY C gene
Follicular Cell Lymphoma (FCL) - CORRECT ANSWERS✅✅t(14;18) translocation
disregulate BCL2, which inhibits apoptosis in B lymphocytes, which leads to survival of
genetically damaged cells
Mantle Cell (MCL) - CORRECT ANSWERS✅✅t(11;14) translocation increases expression
of CCND1
Chronic Myelogenous Leukemia (CML) - CORRECT ANSWERS✅✅t(9;22) aka
Philadelphia Chromosome, translocation occurs within two genes: the breakpoint cluster
region (BCR) on chr.22 and the cellular counter part of the Abelson Leukemia virus tyrosine
kinase (c-abl) on chr.9
Marginal Zone Lymphoma - CORRECT ANSWERS✅✅t(11;18)
Vorinostat/Zolina - CORRECT ANSWERS✅✅second-line drug for cutaneous T-cell
lymphoma. Treatments are often used in combination with phototherapy and chemotherapy
Irinotecan - CORRECT ANSWERS✅✅UGT1A1 - Prevents DNA from unwinding by
inhibition of topoisomerase 1
Warfarin (Coumadin) - CORRECT ANSWERS✅✅CYP2C9 and VKORC1 - Vitamin K
antagonist; metabolized primarily via oxidation in the liver by CYP2C9 and exerts its
, anticoagulant effect by inhibiting the protein vitamin epoxide reductase complex, subunit 1
(VKORC1)
Tamoxifen - CORRECT ANSWERS✅✅CYP2D6 - anti estrogen therapy for hormone
receptor-positive breast cancer in pre-menopausal women
Azathioprine - CORRECT ANSWERS✅✅TPMT - immunosuppresive used in organ
transplant
Carbamazepine - CORRECT ANSWERS✅✅Ineffective to HLA B1502
Plavix - CORRECT ANSWERS✅✅CYP2C19 - anticoagulant (stroke, heart attack)
Herceptin - CORRECT ANSWERS✅✅HER2/Neu - anti Her2/neu
Ribavirin Interferon Therapy - CORRECT ANSWERS✅✅HCV - works really well for
HCV genotype 2 and 3
Carbamazepine - CORRECT ANSWERS✅✅ineffective to HLA B1502
Multiplex PCR - CORRECT ANSWERS✅✅single PCR reaction where more than one
product is made using multiple primer sets
How many times does proficiency testing happen in lab? - CORRECT ANSWERS✅✅at
least twice per year
How do you keep RNA from degrading - CORRECT ANSWERS✅✅long term storage is
best in ethanol at -70C
.3% Agarose - CORRECT ANSWERS✅✅500-60,000
.6% Agarose - CORRECT ANSWERS✅✅1,000-20,000
QUESTIONS AND CORRECT ANSWERS
BCR;ABL1 fusion protein - CORRECT ANSWERS✅✅t(9;22)(q34;q11)
Acute Promyelocytic Leukemia (APL) - CORRECT ANSWERS✅✅t(15;17) a fusion of
PML and RARA
Burkitt's Lymphoma - CORRECT ANSWERS✅✅t(8;14) the breakpoints on chr.8 are
spread of 190 kbp region 5' to and within the C-MY C gene
Follicular Cell Lymphoma (FCL) - CORRECT ANSWERS✅✅t(14;18) translocation
disregulate BCL2, which inhibits apoptosis in B lymphocytes, which leads to survival of
genetically damaged cells
Mantle Cell (MCL) - CORRECT ANSWERS✅✅t(11;14) translocation increases expression
of CCND1
Chronic Myelogenous Leukemia (CML) - CORRECT ANSWERS✅✅t(9;22) aka
Philadelphia Chromosome, translocation occurs within two genes: the breakpoint cluster
region (BCR) on chr.22 and the cellular counter part of the Abelson Leukemia virus tyrosine
kinase (c-abl) on chr.9
Marginal Zone Lymphoma - CORRECT ANSWERS✅✅t(11;18)
Vorinostat/Zolina - CORRECT ANSWERS✅✅second-line drug for cutaneous T-cell
lymphoma. Treatments are often used in combination with phototherapy and chemotherapy
Irinotecan - CORRECT ANSWERS✅✅UGT1A1 - Prevents DNA from unwinding by
inhibition of topoisomerase 1
Warfarin (Coumadin) - CORRECT ANSWERS✅✅CYP2C9 and VKORC1 - Vitamin K
antagonist; metabolized primarily via oxidation in the liver by CYP2C9 and exerts its
, anticoagulant effect by inhibiting the protein vitamin epoxide reductase complex, subunit 1
(VKORC1)
Tamoxifen - CORRECT ANSWERS✅✅CYP2D6 - anti estrogen therapy for hormone
receptor-positive breast cancer in pre-menopausal women
Azathioprine - CORRECT ANSWERS✅✅TPMT - immunosuppresive used in organ
transplant
Carbamazepine - CORRECT ANSWERS✅✅Ineffective to HLA B1502
Plavix - CORRECT ANSWERS✅✅CYP2C19 - anticoagulant (stroke, heart attack)
Herceptin - CORRECT ANSWERS✅✅HER2/Neu - anti Her2/neu
Ribavirin Interferon Therapy - CORRECT ANSWERS✅✅HCV - works really well for
HCV genotype 2 and 3
Carbamazepine - CORRECT ANSWERS✅✅ineffective to HLA B1502
Multiplex PCR - CORRECT ANSWERS✅✅single PCR reaction where more than one
product is made using multiple primer sets
How many times does proficiency testing happen in lab? - CORRECT ANSWERS✅✅at
least twice per year
How do you keep RNA from degrading - CORRECT ANSWERS✅✅long term storage is
best in ethanol at -70C
.3% Agarose - CORRECT ANSWERS✅✅500-60,000
.6% Agarose - CORRECT ANSWERS✅✅1,000-20,000
