NAPLEX ANTIBIOTICS EXAM WITH
CORRECT ACTUAL QUESTIONS AND
CORRECTLY WELL DEFINED ANSWERS
LATEST ALREADY GRADED A+ 2025 – 2026
how long should you take phenazopyridine? - ANSWERS-
only for 2 days - can mask worsening symptoms
treatment for mild/moderate C. diff.? - ANSWERS-
metronidazole 500 mg PO x 10-14 days
*2nd infection: same tx as 1st
*3rd infection: vancomycin taper therapy
treatment for severe C. diff. (WBC > 15,000 or SCr > 1.5)? -
ANSWERS-Vancomycin 125 mg PO QID x 10-14 days
2nd infection: same as 1st
3rd infection: vancomycin taper therapy
,treatment of severe, compicated C. diff. (hypotension,
shock, ileus, megacolon)? - ANSWERS-Vancomycin 500 mg
PO QID + metronidazole 500 mg IV TID
*if complete ileus, add vancomycin per rectum*
treatment of syphillis? - ANSWERS-early latent (< 1 year
duration): penicillin G benzathine (Bicillin LA) 2.4 million
units IM x 1
late latent (> 1 year duration): penicillin G benzathine 2.4
million units IM weekly x 3 weeks
treatment for gonorrhea? - ANSWERS-ceftriaxone 250 mg
IM x 1
+ azithromycin (for co-infection with chlamydia)
OR doxycycline
,treatment for chlamydia? - ANSWERS-azithromycin 1 g PO x
1
treatment for bacterial vaginosis? - ANSWERS-
metronidazole 500 mg PO BID x 7 days (or gel/cream)
what is the MOA of penicillins, cephalosporins,
carbapenems, and vancomycin? - ANSWERS-cell wall
inhibitors - bactericidal
what general ADRs are the black box warning for
aminoglycosides? - ANSWERS-nephrotoxicity and
neurotoxicity
what are the aminoglycosides? - ANSWERS-tobramycin
gentamicin
amikacin
what type of nephrotoxicity do aminoglycosides cause? -
ANSWERS-ATN - acute tubular necrosis
what weight do you use to dose aminoglycosides? -
ANSWERS-IBW (unless TBW is less)
, *use ABW if obese ( > 30% IBW)
what organisms are aminoglycosides mainly active against?
- ANSWERS-gram (-): GNR, PA
extended interval dosing of the aminoglycosides? -
ANSWERS-gent/tobra: 4-7 mg/kg
amikacin: 15-20 mg/kg
*draw random level within 6-16 hours after dose
adjust body weight (ABW) formula? - ANSWERS-IBW +
[0.4(TBW - IBW)]
desired trough (traditional dosing) for gent/tobra? peak? -
ANSWERS-trough: < 2 mcg/mL
peak: 5-10 mcg/mL
Natural pencillins
Penicillin - ANSWERS-Pen VK
Penicillin G Benzathine - ANSWERS-Bicillin L-A
CORRECT ACTUAL QUESTIONS AND
CORRECTLY WELL DEFINED ANSWERS
LATEST ALREADY GRADED A+ 2025 – 2026
how long should you take phenazopyridine? - ANSWERS-
only for 2 days - can mask worsening symptoms
treatment for mild/moderate C. diff.? - ANSWERS-
metronidazole 500 mg PO x 10-14 days
*2nd infection: same tx as 1st
*3rd infection: vancomycin taper therapy
treatment for severe C. diff. (WBC > 15,000 or SCr > 1.5)? -
ANSWERS-Vancomycin 125 mg PO QID x 10-14 days
2nd infection: same as 1st
3rd infection: vancomycin taper therapy
,treatment of severe, compicated C. diff. (hypotension,
shock, ileus, megacolon)? - ANSWERS-Vancomycin 500 mg
PO QID + metronidazole 500 mg IV TID
*if complete ileus, add vancomycin per rectum*
treatment of syphillis? - ANSWERS-early latent (< 1 year
duration): penicillin G benzathine (Bicillin LA) 2.4 million
units IM x 1
late latent (> 1 year duration): penicillin G benzathine 2.4
million units IM weekly x 3 weeks
treatment for gonorrhea? - ANSWERS-ceftriaxone 250 mg
IM x 1
+ azithromycin (for co-infection with chlamydia)
OR doxycycline
,treatment for chlamydia? - ANSWERS-azithromycin 1 g PO x
1
treatment for bacterial vaginosis? - ANSWERS-
metronidazole 500 mg PO BID x 7 days (or gel/cream)
what is the MOA of penicillins, cephalosporins,
carbapenems, and vancomycin? - ANSWERS-cell wall
inhibitors - bactericidal
what general ADRs are the black box warning for
aminoglycosides? - ANSWERS-nephrotoxicity and
neurotoxicity
what are the aminoglycosides? - ANSWERS-tobramycin
gentamicin
amikacin
what type of nephrotoxicity do aminoglycosides cause? -
ANSWERS-ATN - acute tubular necrosis
what weight do you use to dose aminoglycosides? -
ANSWERS-IBW (unless TBW is less)
, *use ABW if obese ( > 30% IBW)
what organisms are aminoglycosides mainly active against?
- ANSWERS-gram (-): GNR, PA
extended interval dosing of the aminoglycosides? -
ANSWERS-gent/tobra: 4-7 mg/kg
amikacin: 15-20 mg/kg
*draw random level within 6-16 hours after dose
adjust body weight (ABW) formula? - ANSWERS-IBW +
[0.4(TBW - IBW)]
desired trough (traditional dosing) for gent/tobra? peak? -
ANSWERS-trough: < 2 mcg/mL
peak: 5-10 mcg/mL
Natural pencillins
Penicillin - ANSWERS-Pen VK
Penicillin G Benzathine - ANSWERS-Bicillin L-A
