Biochem apmle part 1 Questions With Complete Solutions
_____ are proteins to which oligosaccharides are covalently
attached.
b) They contain highly variable amounts of carbohydrate but
typically ____ than that of proteoglycans.
c) In glycoproteins, the glycan is relatively short (usually 2-10
sugar residues);
d)does or does not? contain repeating disaccharide units
e)and is structurally diverse; is often ______ instead of linear;
and may or may not be negatively charged. Correct Answers
glycoprotein
less than that of proteoglycan
it does not contain repeating disaccaride units
branched , may or may not have neg charge
- make slides about the difference of activation for glycolysis vs
glycogenesis Correct Answers make slides
· With the exception of _, which is a lipid-soluble quinone, all
members of the ETC are proteins. Correct Answers coq
2 organs that oxidize lactate to pyruvate?
fate of lacate:
,liver?
heart? Correct Answers liver , heart
liver, pyruvate is either converted to glucose by gluconeogenesis
or converted to acetyl CoA that is oxidized in the TCA cycle.
heart exclusively oxidizes to co2 and h2o via tca
a mature red blood cell relies on what for ATP d/t a lack of
mitochondria
what kind of anemia is observed in patients with enzyme
deficincies related to this process ? when are they resistant to
malaria and what dictates the severity? Correct Answers
glycolysis
non spheroctyic .
hets = r to malaria
2,3 bpg production to compensate
acidic sugar syn
D-glucoronic , L-iduronic
which one is rq for detox of lipophillic compounds [bilirubin,
steroids,etc] because conjugation with it --> increases water
solubility. also a precursor for vit c in plants and mammals.
glucoronic acid: 2 sources from breakdown:
,if i wanted so synthesize it...what is my precursor, what does it
react with...then, that product is ___ to glucoronic acid
end product of glucoronic acid metabolism: __-______-__-
_______ , which can enter PPP
uronosyl 5. epimerase ==> D glucoronic ==> L-iduronic acid,
before or after D glucoronic is made? Correct Answers D
glucoronic
diet, lysosomal gag degradation
synthesis: g1p + UTP ==> udp-glucose --> oxiddized ==>
glucoronic acid
d-xylulose 5 phosphate
after
adding the sulfate group: GAG/pglycans
occurs before?after? the monosaccaride[to be sulfated] is
incorporaterd into a growing carb chain
source of sulfate?
sulfonyltransferases: the enzyme that reaction is catalyzed by
[t/f] Correct Answers after
PAPS
T
, all gags excepted _______ ____ are sulfated, and found
covalently attatched to protein --> forming proteoglycan
monomers Correct Answers hyaluronic acid
all globular proteins are glycoproteins except for ____
main role: cell - cell signaling or ECM substance?
exs?
what about proteoglycan, what are they for? Correct Answers
albumin
cell - cell signaling
collagens, mucins, ig, transferrins
ecm
Allosteric Activation by Acetyl CoA
• Allosteric activation of hepatic PC by acetyl CoA occurs
during fed state [t/f]
• With increased TAG hydrolysis in adipose tissue, the liver is
flooded with FA.
• The rate of formation of acetyl CoA by β- oxidation of these
FA [>/<] the capacity of the liver to oxidize it to CO2 and water
==> As a result, acetyl CoA accumulates and activates PC.
Correct Answers Allosteric Activation by Acetyl CoA
• Allosteric activation of hepatic PC by acetyl CoA occurs
during fasting.
• With increased TAG hydrolysis in adipose tissue, the liver is
flooded with FA.
_____ are proteins to which oligosaccharides are covalently
attached.
b) They contain highly variable amounts of carbohydrate but
typically ____ than that of proteoglycans.
c) In glycoproteins, the glycan is relatively short (usually 2-10
sugar residues);
d)does or does not? contain repeating disaccharide units
e)and is structurally diverse; is often ______ instead of linear;
and may or may not be negatively charged. Correct Answers
glycoprotein
less than that of proteoglycan
it does not contain repeating disaccaride units
branched , may or may not have neg charge
- make slides about the difference of activation for glycolysis vs
glycogenesis Correct Answers make slides
· With the exception of _, which is a lipid-soluble quinone, all
members of the ETC are proteins. Correct Answers coq
2 organs that oxidize lactate to pyruvate?
fate of lacate:
,liver?
heart? Correct Answers liver , heart
liver, pyruvate is either converted to glucose by gluconeogenesis
or converted to acetyl CoA that is oxidized in the TCA cycle.
heart exclusively oxidizes to co2 and h2o via tca
a mature red blood cell relies on what for ATP d/t a lack of
mitochondria
what kind of anemia is observed in patients with enzyme
deficincies related to this process ? when are they resistant to
malaria and what dictates the severity? Correct Answers
glycolysis
non spheroctyic .
hets = r to malaria
2,3 bpg production to compensate
acidic sugar syn
D-glucoronic , L-iduronic
which one is rq for detox of lipophillic compounds [bilirubin,
steroids,etc] because conjugation with it --> increases water
solubility. also a precursor for vit c in plants and mammals.
glucoronic acid: 2 sources from breakdown:
,if i wanted so synthesize it...what is my precursor, what does it
react with...then, that product is ___ to glucoronic acid
end product of glucoronic acid metabolism: __-______-__-
_______ , which can enter PPP
uronosyl 5. epimerase ==> D glucoronic ==> L-iduronic acid,
before or after D glucoronic is made? Correct Answers D
glucoronic
diet, lysosomal gag degradation
synthesis: g1p + UTP ==> udp-glucose --> oxiddized ==>
glucoronic acid
d-xylulose 5 phosphate
after
adding the sulfate group: GAG/pglycans
occurs before?after? the monosaccaride[to be sulfated] is
incorporaterd into a growing carb chain
source of sulfate?
sulfonyltransferases: the enzyme that reaction is catalyzed by
[t/f] Correct Answers after
PAPS
T
, all gags excepted _______ ____ are sulfated, and found
covalently attatched to protein --> forming proteoglycan
monomers Correct Answers hyaluronic acid
all globular proteins are glycoproteins except for ____
main role: cell - cell signaling or ECM substance?
exs?
what about proteoglycan, what are they for? Correct Answers
albumin
cell - cell signaling
collagens, mucins, ig, transferrins
ecm
Allosteric Activation by Acetyl CoA
• Allosteric activation of hepatic PC by acetyl CoA occurs
during fed state [t/f]
• With increased TAG hydrolysis in adipose tissue, the liver is
flooded with FA.
• The rate of formation of acetyl CoA by β- oxidation of these
FA [>/<] the capacity of the liver to oxidize it to CO2 and water
==> As a result, acetyl CoA accumulates and activates PC.
Correct Answers Allosteric Activation by Acetyl CoA
• Allosteric activation of hepatic PC by acetyl CoA occurs
during fasting.
• With increased TAG hydrolysis in adipose tissue, the liver is
flooded with FA.
