UWSA 2 CORE EXAM MANUAL UPDATED QUESTIONS
AND ANSWERS RATED A+
✔✔Venous drainage of the rectum above the dentate line - ✔✔superior rectal vein
drains into the portal venous system via the inferior mesenteric vein
✔✔venous drainage of the rectum below the dentate line - ✔✔middle and inferior rectal
veins drain into the caval system
✔✔Diff between a ToF vs VSD or PDA in an infant - ✔✔typically only a ToF will be
symptomatic in an infant
VSD and PDA shunts do not shunt right-to-left until later in the disease course
✔✔danazol - ✔✔androgen used to suppress FSH and LH release by the pituitary gland
used in endometriosis, hemophilia, immune thrombocytopenic purpura
✔✔Bromocriptin - ✔✔dopamine receptor agonist that inhibits pituitary prolactin
secretion
✔✔pt has swollen parotid glands and testicular tenderness. diagnosis and treatment? -
✔✔Mumps! Can occur in adults who were inadequately vaccinated (immigrants)
orchitis can cause seminiferous tubule atrophy - give testosterone
✔✔Probenecid coadministration with penicillin? - ✔✔Blocks organic anion transporters
on renal tubular cells to inhibit tubular secretion of certain antibiotics (penicillin)
can be used to enhance penicillin's efficacy in certain clinical settings
✔✔what are NF1 neurofibromas a derivative of - ✔✔they are nerve trunks within the
skin and deeper tissues
loose, disorganized proliferations of schwann cells, fibroblasts, and neurites
✔✔Common peroneal nerve - ✔✔deep peroneal nerve
causes foot drop
superficial peroneal nerve
causes sensory loss over the lateral leg and dorsolateral foot
✔✔Orotic aciduria - ✔✔ornithine transcarbamoylase deficiency
, results in accumulation of carbamoyl phosphate, which is converted to orotic acid by the
pyrmidine biosynthetic pathway
and congenital hyperammonemia
✔✔which steps of collagen synthesis happen inside the cell - ✔✔cleavage of signal
sequence
hydroxylation of proline and lysine (vit c dep)
glycosylation of hydroxylysine
assembly of pro alpha chains into procollagen triple helix
✔✔which steps of collagen synthesis happen outside the cell - ✔✔terminal propeptides
cleaved by N and C procollagen peptidases
collagen molecules spontaneously assemble
covalent cross linksn formed by lysyl oxidase
✔✔uncal herniation - ✔✔the uncus (most medial part of the parahippocampal gyrus) is
pressed through the tentorium cerebelli into the infratentorial space
results in a fixed and dilated pupil on the ipsilateral side due to interruption of
parasympathetic fibers innervating the iris (in the outermost part of CN III)
✔✔tonsillar herniation - ✔✔contents of the posterior fossa are forced out of the foramen
magnum at the base of the skull
tonsils are pushed down, compress the medulla
respiratory depression and death
✔✔low PTH and bone - ✔✔hypoparathyroidism can cause serum Ca levels to be low
but the bone will be relatively unchanged - low PTH levels cause decreased bone
resorption
✔✔How does an ACEi affect ATII and renin - ✔✔ATII goes down
renin goes up
this is because ATII inhibits renin release
Less ATII = less negative feedback on renin (JGA cells)
AND ANSWERS RATED A+
✔✔Venous drainage of the rectum above the dentate line - ✔✔superior rectal vein
drains into the portal venous system via the inferior mesenteric vein
✔✔venous drainage of the rectum below the dentate line - ✔✔middle and inferior rectal
veins drain into the caval system
✔✔Diff between a ToF vs VSD or PDA in an infant - ✔✔typically only a ToF will be
symptomatic in an infant
VSD and PDA shunts do not shunt right-to-left until later in the disease course
✔✔danazol - ✔✔androgen used to suppress FSH and LH release by the pituitary gland
used in endometriosis, hemophilia, immune thrombocytopenic purpura
✔✔Bromocriptin - ✔✔dopamine receptor agonist that inhibits pituitary prolactin
secretion
✔✔pt has swollen parotid glands and testicular tenderness. diagnosis and treatment? -
✔✔Mumps! Can occur in adults who were inadequately vaccinated (immigrants)
orchitis can cause seminiferous tubule atrophy - give testosterone
✔✔Probenecid coadministration with penicillin? - ✔✔Blocks organic anion transporters
on renal tubular cells to inhibit tubular secretion of certain antibiotics (penicillin)
can be used to enhance penicillin's efficacy in certain clinical settings
✔✔what are NF1 neurofibromas a derivative of - ✔✔they are nerve trunks within the
skin and deeper tissues
loose, disorganized proliferations of schwann cells, fibroblasts, and neurites
✔✔Common peroneal nerve - ✔✔deep peroneal nerve
causes foot drop
superficial peroneal nerve
causes sensory loss over the lateral leg and dorsolateral foot
✔✔Orotic aciduria - ✔✔ornithine transcarbamoylase deficiency
, results in accumulation of carbamoyl phosphate, which is converted to orotic acid by the
pyrmidine biosynthetic pathway
and congenital hyperammonemia
✔✔which steps of collagen synthesis happen inside the cell - ✔✔cleavage of signal
sequence
hydroxylation of proline and lysine (vit c dep)
glycosylation of hydroxylysine
assembly of pro alpha chains into procollagen triple helix
✔✔which steps of collagen synthesis happen outside the cell - ✔✔terminal propeptides
cleaved by N and C procollagen peptidases
collagen molecules spontaneously assemble
covalent cross linksn formed by lysyl oxidase
✔✔uncal herniation - ✔✔the uncus (most medial part of the parahippocampal gyrus) is
pressed through the tentorium cerebelli into the infratentorial space
results in a fixed and dilated pupil on the ipsilateral side due to interruption of
parasympathetic fibers innervating the iris (in the outermost part of CN III)
✔✔tonsillar herniation - ✔✔contents of the posterior fossa are forced out of the foramen
magnum at the base of the skull
tonsils are pushed down, compress the medulla
respiratory depression and death
✔✔low PTH and bone - ✔✔hypoparathyroidism can cause serum Ca levels to be low
but the bone will be relatively unchanged - low PTH levels cause decreased bone
resorption
✔✔How does an ACEi affect ATII and renin - ✔✔ATII goes down
renin goes up
this is because ATII inhibits renin release
Less ATII = less negative feedback on renin (JGA cells)
