Schizophrenia: Pathophysiology and Etiology well answered

Schizophrenia: Pathophysiology and
Etiology well answered

what is the dopamine hypothesis?

-hyperactivity of DA in the mesolimbic pathway leads to positive symptoms or psychosis

-hypoactivity of DA in the neocortical pathway leads to negative and cognitive symptoms

-when the nigrostriatal pathway is blocked, EPS appears

-the tuberoinfundibular pathway inhibits prolactin release




the mesolimbic pathway originates in the ? and ends in the ?

VTA, NAC




the mesocortical pathway begins ? and ends?

VTA, Cortex




the nigrostriatal pathway begins in the ? and ends?

SN, striatum




the tuberoinfundibular pathway begins ? and ends?

pituitary, hypothalamus

, how is serotonin related to schizophrenia?

-serotonin/5-HT has an inhibitory effect on DA release. By increase in 5HT transmission and
transporter density in subcortical regions, it inhibits DA release.

-Antagonism of 5HT2A receptor= increase in DA in prefrontal cortex




dopamine leads to what symptoms?

positive




serotonin leads to what symptoms?

negative and cognitive




glutamate leads to what symptoms?

negative and cognitive




GABA leads to what symptoms?

negative symptoms




acetylcholine leads to what symptoms?

cognitive and positive