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FUNDAMENTALS OF CHEMOTHERAPY
IMMUNOTHERAPY ADMINISTRATION
EXAM QUESTIONS WITH ANSWERS.
Cytokines - correct answer --proteins made by immune and non-
immune cells
-can be made in lab
-some stimulate immune system, some slow it down
Interferons - correct answer --natural substance made by WBC to
fight diseases
-can be made in lab
-help keel cancer cells from growing, kills cancer cells
-SI and fatigue
Interleukin (IL) - correct answer --proteins made by WBC and
other cells
-regulate immune response
-lab made: boost immune system in CA treatment
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Immunomodulators - correct answer --multiple myeloma
-change the body's immune system
-agents activate/suppress function
Monoclonal antibodies - correct answer --lab made antibodies
-mimic antibodies in immune system
Murine - made from mice
Chimeric - part mouse/part human
Humanized - mice antibodies attach human antibodies
Human - fully human antibodies
Rituximab - correct answer --M antibodies (nAbs)
-mixed mice/human
-treat: non-hodgkkins, CLL, RA, granulomatosis, polyangiitis
-IV only
-premed w/ tylenol, benadryl,
-hold HTN meds for previous 12 hrs
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Trastuzumab - correct answer -- breast and gastric CA
-mAb - HUMANIZED
-IV only
- no previous cardiac condition, not pregnant
Angiogenesis - correct answer --blood vessel formation
*tumor angiogenesis - new blood vessels tumors need to grow
-release of chemicals by tumor and by host cells
Antiangiogenic Agents - correct answer --keep new blood vessels
from forming
-prevent growth of new blood vessels tumors need to grow
Bevacizumab - correct answer --colon, lung, glioblastoma, renal,
off label
-mAb- humanized
-IV (do not push), intravitreal (unlabled)
-can cause GI perf, protenuria, fistula, hemorrhage
-do not give 28 days before surgery
FUNDAMENTALS OF CHEMOTHERAPY
IMMUNOTHERAPY ADMINISTRATION
EXAM QUESTIONS WITH ANSWERS.
Cytokines - correct answer --proteins made by immune and non-
immune cells
-can be made in lab
-some stimulate immune system, some slow it down
Interferons - correct answer --natural substance made by WBC to
fight diseases
-can be made in lab
-help keel cancer cells from growing, kills cancer cells
-SI and fatigue
Interleukin (IL) - correct answer --proteins made by WBC and
other cells
-regulate immune response
-lab made: boost immune system in CA treatment
, Page | 2
Immunomodulators - correct answer --multiple myeloma
-change the body's immune system
-agents activate/suppress function
Monoclonal antibodies - correct answer --lab made antibodies
-mimic antibodies in immune system
Murine - made from mice
Chimeric - part mouse/part human
Humanized - mice antibodies attach human antibodies
Human - fully human antibodies
Rituximab - correct answer --M antibodies (nAbs)
-mixed mice/human
-treat: non-hodgkkins, CLL, RA, granulomatosis, polyangiitis
-IV only
-premed w/ tylenol, benadryl,
-hold HTN meds for previous 12 hrs
, Page | 3
Trastuzumab - correct answer -- breast and gastric CA
-mAb - HUMANIZED
-IV only
- no previous cardiac condition, not pregnant
Angiogenesis - correct answer --blood vessel formation
*tumor angiogenesis - new blood vessels tumors need to grow
-release of chemicals by tumor and by host cells
Antiangiogenic Agents - correct answer --keep new blood vessels
from forming
-prevent growth of new blood vessels tumors need to grow
Bevacizumab - correct answer --colon, lung, glioblastoma, renal,
off label
-mAb- humanized
-IV (do not push), intravitreal (unlabled)
-can cause GI perf, protenuria, fistula, hemorrhage
-do not give 28 days before surgery
