Clinical presentation of breast cancer 4/17
1. what type of imaging modality is most sensitive: MRI
2. what type of imaging modality is more specific: mammogram
3. who are MRIs recommended in: women with a 20% or greater lifetime risk of breast cancer
4. when is an ultrasound used: for diagnosis/biopsy of a palpable mass or mammographic chnage
5. what does US improve: sensitivity
specificity
positive predictive value
6. what Bi-Rads score should you start considering biopsy: 4a
7. what Bi-Rads score should you do a biopsy: 5
8. what Bi-Rads score is known cancer: 6
9. when is open biopsy used: when there is a nonconcordant pathology result or concern for upgrade in
1/3
, diagnosis
10. concordance: radiographic appearance = pathologic diagnosis
11. ischemic time after biopsy: less than 1 hour
12. fixation time after biopsy: 6-72 hours
13. SMMS and p40 in invasive carcinoma: usually lost
14. 8-9 on nottingham score: poorly differentiated
15. tubule score of 3: < 10% tubules
16. mitotic count score of 3: >11
17. what is E-cadherin lost in: invasive lobular carcinoma
18. what does invasive ductal have a tendency to form: tubular structures
19. hormone receptor and e cadherin in invasive lobular: hormone receptor positive and e
cadherin negative
2/3
1. what type of imaging modality is most sensitive: MRI
2. what type of imaging modality is more specific: mammogram
3. who are MRIs recommended in: women with a 20% or greater lifetime risk of breast cancer
4. when is an ultrasound used: for diagnosis/biopsy of a palpable mass or mammographic chnage
5. what does US improve: sensitivity
specificity
positive predictive value
6. what Bi-Rads score should you start considering biopsy: 4a
7. what Bi-Rads score should you do a biopsy: 5
8. what Bi-Rads score is known cancer: 6
9. when is open biopsy used: when there is a nonconcordant pathology result or concern for upgrade in
1/3
, diagnosis
10. concordance: radiographic appearance = pathologic diagnosis
11. ischemic time after biopsy: less than 1 hour
12. fixation time after biopsy: 6-72 hours
13. SMMS and p40 in invasive carcinoma: usually lost
14. 8-9 on nottingham score: poorly differentiated
15. tubule score of 3: < 10% tubules
16. mitotic count score of 3: >11
17. what is E-cadherin lost in: invasive lobular carcinoma
18. what does invasive ductal have a tendency to form: tubular structures
19. hormone receptor and e cadherin in invasive lobular: hormone receptor positive and e
cadherin negative
2/3
