CURRENT Medical Diagnosis and
Treatment 2026
65th Edition
Author(s)Maxine A. Papadakis; Michael
W. Rabow; Kenneth R. McQuaid; Paul L.
Nadler; Erika Leemann Price
TEST BANK
1
Reference
Ch. 1 — Disease Prevention & Health Promotion — Health
Maintenance & Disease Prevention. AccessMedicine
Question Stem
A 58-year-old man with well-controlled hypertension asks which
,cancer screening will yield the greatest mortality benefit for
him. He is a current smoker (30 pack-years). Which screening
recommendation is most supported by population-level
mortality reduction?
A. Annual low-dose CT scan for lung cancer beginning now.
B. Colonoscopy every 10 years starting at age 50.
C. PSA testing annually for prostate cancer.
D. Annual chest radiograph for early lung cancer detection.
Correct Answer
A
Rationales
• Correct (A): Low-dose CT screening in adults with
significant smoking history reduces lung-cancer mortality
and is recommended for appropriate high-risk patients; it
provides the greatest mortality benefit for long-term
smokers compared with chest radiograph.
• B (incorrect): Colonoscopy does reduce colorectal cancer
mortality but for this patient the immediate highest-yield,
mortality-reducing screening given smoking risk is lung CT;
colonoscopy timing is important but not the single greatest
mortality-reducing test here.
• C (incorrect): PSA screening remains individualized
because of trade-offs in harms and benefits and does not
have the consistent population-level mortality reduction
seen with low-dose CT in high-risk smokers.
, • D (incorrect): Chest radiograph does not reduce lung-
cancer mortality and is not recommended for screening.
Teaching Point
Low-dose CT reduces lung cancer mortality in high-risk smokers.
Citation (Simplified APA)
Papadakis et al. (2025). CURRENT Medical Diagnosis &
Treatment 2026 (65th Ed.). Ch. 1. AccessMedicine
2
Reference
Ch. 1 — Disease Prevention & Health Promotion — Health
Maintenance & Disease Prevention. AccessMedicine
Question Stem
A 26-year-old woman who is planning pregnancy asks about
preconception immunizations. Which vaccination should be
given before conception to reduce fetal risk?
A. Inactivated influenza vaccine this season.
B. Live attenuated MMR vaccine now.
C. Tdap booster in the first trimester.
D. Live attenuated varicella vaccine during pregnancy.
Correct Answer
B
Rationales
, • Correct (B): MMR (measles–mumps–rubella) is a live
vaccine and should be administered before conception
because rubella infection during pregnancy risks severe
fetal anomalies.
• A (incorrect): Inactivated influenza vaccine is safe during
pregnancy and can be given any time but is not specifically
required before conception.
• C (incorrect): Tdap is recommended during each
pregnancy (preferably 27–36 weeks), not routinely in the
first trimester preconception.
• D (incorrect): Live varicella vaccine should not be given
during pregnancy; it should be administered before
conception if nonimmune.
Teaching Point
Administer live vaccines (e.g., MMR, varicella) before
conception; avoid live vaccines during pregnancy.
Citation (Simplified APA)
Papadakis et al. (2025). CURRENT Medical Diagnosis &
Treatment 2026 (65th Ed.). Ch. 1. AccessMedicine
3
Reference
Ch. 1 — Disease Prevention & Health Promotion — Health
Maintenance & Disease Prevention. AccessMedicine
Treatment 2026
65th Edition
Author(s)Maxine A. Papadakis; Michael
W. Rabow; Kenneth R. McQuaid; Paul L.
Nadler; Erika Leemann Price
TEST BANK
1
Reference
Ch. 1 — Disease Prevention & Health Promotion — Health
Maintenance & Disease Prevention. AccessMedicine
Question Stem
A 58-year-old man with well-controlled hypertension asks which
,cancer screening will yield the greatest mortality benefit for
him. He is a current smoker (30 pack-years). Which screening
recommendation is most supported by population-level
mortality reduction?
A. Annual low-dose CT scan for lung cancer beginning now.
B. Colonoscopy every 10 years starting at age 50.
C. PSA testing annually for prostate cancer.
D. Annual chest radiograph for early lung cancer detection.
Correct Answer
A
Rationales
• Correct (A): Low-dose CT screening in adults with
significant smoking history reduces lung-cancer mortality
and is recommended for appropriate high-risk patients; it
provides the greatest mortality benefit for long-term
smokers compared with chest radiograph.
• B (incorrect): Colonoscopy does reduce colorectal cancer
mortality but for this patient the immediate highest-yield,
mortality-reducing screening given smoking risk is lung CT;
colonoscopy timing is important but not the single greatest
mortality-reducing test here.
• C (incorrect): PSA screening remains individualized
because of trade-offs in harms and benefits and does not
have the consistent population-level mortality reduction
seen with low-dose CT in high-risk smokers.
, • D (incorrect): Chest radiograph does not reduce lung-
cancer mortality and is not recommended for screening.
Teaching Point
Low-dose CT reduces lung cancer mortality in high-risk smokers.
Citation (Simplified APA)
Papadakis et al. (2025). CURRENT Medical Diagnosis &
Treatment 2026 (65th Ed.). Ch. 1. AccessMedicine
2
Reference
Ch. 1 — Disease Prevention & Health Promotion — Health
Maintenance & Disease Prevention. AccessMedicine
Question Stem
A 26-year-old woman who is planning pregnancy asks about
preconception immunizations. Which vaccination should be
given before conception to reduce fetal risk?
A. Inactivated influenza vaccine this season.
B. Live attenuated MMR vaccine now.
C. Tdap booster in the first trimester.
D. Live attenuated varicella vaccine during pregnancy.
Correct Answer
B
Rationales
, • Correct (B): MMR (measles–mumps–rubella) is a live
vaccine and should be administered before conception
because rubella infection during pregnancy risks severe
fetal anomalies.
• A (incorrect): Inactivated influenza vaccine is safe during
pregnancy and can be given any time but is not specifically
required before conception.
• C (incorrect): Tdap is recommended during each
pregnancy (preferably 27–36 weeks), not routinely in the
first trimester preconception.
• D (incorrect): Live varicella vaccine should not be given
during pregnancy; it should be administered before
conception if nonimmune.
Teaching Point
Administer live vaccines (e.g., MMR, varicella) before
conception; avoid live vaccines during pregnancy.
Citation (Simplified APA)
Papadakis et al. (2025). CURRENT Medical Diagnosis &
Treatment 2026 (65th Ed.). Ch. 1. AccessMedicine
3
Reference
Ch. 1 — Disease Prevention & Health Promotion — Health
Maintenance & Disease Prevention. AccessMedicine
