Theme I notes - integration of metabolism

Theme I – integration of metabolism What is metabolism?

Lecture I1 – overview of metabolism, compartmentalization of • Chemical reactions in living systems
metabolism and metabolism in specific tissues - provide energy for cellular work
- synthesize biomolecules - anabolism
Central pathways of energy metabolism
- degrade biomolecules – catabolism

Metabolism is divided into two distinct groups of chemical
reactions linked by primary coupling agents:

- ATP/ADP
- NADPH/NADP+

Anabolism - reductive, uses NADPH

Catabolism - oxidative, produces NADH(→NADPH)




Integration of metabolism

1. Overview and compartmentalization
2. Metabolism in specific tissues and Regulation
3. Starvation and diabetes
4. Integration of metabolism in plants (Self-study)

,Metabolic pathways Recovery: anabolism

• Reaction pathways coupled in network of linked reactions
• Reactions are catalyzed by enzymes
• Reactions and pathways are tightly regulated




Energy metabolism and O2

Anaerobic production of ATP


Energy production: catabolism

, Energy metabolism and O2 Compartmentalization of pathways in animals

Aerobic production of ATP • Certain pathways are confined to certain organs
• Certain enzymes are confined to a cellular compartment
(organelles)
• Anabolic reactions usually take place in the cytosol
• Catabolic reactions usually take place in the mitochondria
• Certain compounds (coenzymes, substrates, products)
may be confined to a cellular compartment




Anabolism and catabolism are functionally coupled