GMS6552 EXAM Questions AND Correct Answers
_________ are the primary mediators of TGF-b signaling - ✔✔SMADs
____-SMAD is an inhibitory SMAD that blocks R-SMAD binding to Type I
receptor or SMAD 4. I-SMADs act via _______ inhibition. - ✔✔I-SMAD;
Competitive
___-SMADs are the primary SMADs that get phosphorylated by the Type 1
receptor Ser/Thr kinases. - ✔✔R-SMADs
A GRK inhibitor would have what effect on GPCR inactivation in the presence of
a GPCR agonist?
It would decrease it
It would maintain the same rate of inactivation
It would increase it - ✔✔It would decrease it
Adenylyl cyclase increases - ✔✔cAMP
alpha I subunit of G proteins inhibits - ✔✔Adenylyl cyclase
alpha q subunit of G protein activates - ✔✔PLC
alpha S subunit of G protein activates - ✔✔adenylyl cyclase
,Assume you have receptor antagonists that are able to stop receptor signaling
immediately. For which type of receptor would it take the longest to see the
effects of your drug at the cellular level?
Kinase-linked receptors
Channel-linked receptors
Nuclear receptors
G-protein coupled receptors - ✔✔Nuclear receptors
b-arrestin has what effect on ERK signaling?
Increases it
Has no effect on it
Decreases it - ✔✔Increases it
Based on the effects of NF-kB signaling, would cancer cells be expected to
increase or decrease its activity for their own benefit? - ✔✔Increase
cAMP activates - ✔✔PKA
Class name for Channel-linked Receptors - ✔✔Ionotropic receptors
Class name for GPCRs - ✔✔Metabotropic Receptors
DAG activates - ✔✔PKC
Death ligands directly activate the _______ apoptotic pathway.
, Intrinsic
Extrinsic - ✔✔Extrinsic
Different SMAD complexes bind different genes. Which group of SMADs is
responsible for this specificity?
R-SMADs
Co-SMADs
I-SMADs - ✔✔R-SMADs
Does TGF-b treatment cause cells to grow more or less in the soft agar assay? -
✔✔More
Does the presence of oncogenes make it harder or easier to develop selective
anti-cancer agents with fewer side effects? - ✔✔Easier
Early CAs, turn ______ TGF-b
Later CAs, will turn TGF-b ______. - ✔✔Off; On
Example of Channel-linked Receptors - ✔✔Nicotinic/ACh Receptors
Example of GPCRs - ✔✔Muscarinic/ACh Receptors
For which type of receptor would having adequate membrane permeability of
an agonist be most critical?
Kinase-linked receptors
_________ are the primary mediators of TGF-b signaling - ✔✔SMADs
____-SMAD is an inhibitory SMAD that blocks R-SMAD binding to Type I
receptor or SMAD 4. I-SMADs act via _______ inhibition. - ✔✔I-SMAD;
Competitive
___-SMADs are the primary SMADs that get phosphorylated by the Type 1
receptor Ser/Thr kinases. - ✔✔R-SMADs
A GRK inhibitor would have what effect on GPCR inactivation in the presence of
a GPCR agonist?
It would decrease it
It would maintain the same rate of inactivation
It would increase it - ✔✔It would decrease it
Adenylyl cyclase increases - ✔✔cAMP
alpha I subunit of G proteins inhibits - ✔✔Adenylyl cyclase
alpha q subunit of G protein activates - ✔✔PLC
alpha S subunit of G protein activates - ✔✔adenylyl cyclase
,Assume you have receptor antagonists that are able to stop receptor signaling
immediately. For which type of receptor would it take the longest to see the
effects of your drug at the cellular level?
Kinase-linked receptors
Channel-linked receptors
Nuclear receptors
G-protein coupled receptors - ✔✔Nuclear receptors
b-arrestin has what effect on ERK signaling?
Increases it
Has no effect on it
Decreases it - ✔✔Increases it
Based on the effects of NF-kB signaling, would cancer cells be expected to
increase or decrease its activity for their own benefit? - ✔✔Increase
cAMP activates - ✔✔PKA
Class name for Channel-linked Receptors - ✔✔Ionotropic receptors
Class name for GPCRs - ✔✔Metabotropic Receptors
DAG activates - ✔✔PKC
Death ligands directly activate the _______ apoptotic pathway.
, Intrinsic
Extrinsic - ✔✔Extrinsic
Different SMAD complexes bind different genes. Which group of SMADs is
responsible for this specificity?
R-SMADs
Co-SMADs
I-SMADs - ✔✔R-SMADs
Does TGF-b treatment cause cells to grow more or less in the soft agar assay? -
✔✔More
Does the presence of oncogenes make it harder or easier to develop selective
anti-cancer agents with fewer side effects? - ✔✔Easier
Early CAs, turn ______ TGF-b
Later CAs, will turn TGF-b ______. - ✔✔Off; On
Example of Channel-linked Receptors - ✔✔Nicotinic/ACh Receptors
Example of GPCRs - ✔✔Muscarinic/ACh Receptors
For which type of receptor would having adequate membrane permeability of
an agonist be most critical?
Kinase-linked receptors
