ANPS 8005 Wk 2 Antipsychotics
Questions With Outlined Answers
\.MOA of typical antipsychotics?
D2 receptor antagonism in mesocortical, mesolimbic, substantia niagra, and pituitary
(tuberoinfundibular) pathways producing a more selective and widespread DA blockade.
\.MOA of atypical antipsychotics?
5HT2A receptor antagonism and inverse agonism in mesocortical and mesolimbic pathways
stimulates DA and prolactin release which encourages the release of endogenous DA that
competes with the antipsychotic drug for binding to D2 receptors thereby decreasing the
occupancy of D2 receptor.
\.Antipsychotics with root "-pine"?
Clozapine, Olanzapine, Quetiapine,
\.Antipsychotics with root "-done"?
Risperidone, Paliperidone, Lurasidone, Iloperidone
\.Antipsychotics with root "-pip"?
Aripiprazole, Brexpiprazole
\.Antipsychotics with root "-rip"?
Cariprazine
, \.Antipsychotic with the least EPS and hyperprolactinemia and the most metabolic,
anticholinergic, and sedating effects?
-pines
\.Antipsychotics with the most hyperprolactinemic and EPS effects?
-dones
\.Antipsychotics with most hypotensive effects and QT prolongation?
-pines, -ones (except Lurasidone)
\.Antipsychotics associated with the most akathisia?
-pips, -rip
\.Antipsychotics with the least cardiometabolic and sedation effects?
-pips, -rips, -dones
\.Antipsychotics associated with the least hypotensive side effects and QT prolongation?
-pips, -rips, Lurasidone
\.Antipsychotic(s) associated with comorbid anxiety and depression?
Quetiapine (Seroquel)
\,Antipsychotic(s) that must be taken with food?
Ziprasidone and Lurasidone
\.Antipsychotic that acts as a 5HT2A inverse agonist with no direct D2 receptor activity and is
approved to treat Parkinsonian Psychosis?
Questions With Outlined Answers
\.MOA of typical antipsychotics?
D2 receptor antagonism in mesocortical, mesolimbic, substantia niagra, and pituitary
(tuberoinfundibular) pathways producing a more selective and widespread DA blockade.
\.MOA of atypical antipsychotics?
5HT2A receptor antagonism and inverse agonism in mesocortical and mesolimbic pathways
stimulates DA and prolactin release which encourages the release of endogenous DA that
competes with the antipsychotic drug for binding to D2 receptors thereby decreasing the
occupancy of D2 receptor.
\.Antipsychotics with root "-pine"?
Clozapine, Olanzapine, Quetiapine,
\.Antipsychotics with root "-done"?
Risperidone, Paliperidone, Lurasidone, Iloperidone
\.Antipsychotics with root "-pip"?
Aripiprazole, Brexpiprazole
\.Antipsychotics with root "-rip"?
Cariprazine
, \.Antipsychotic with the least EPS and hyperprolactinemia and the most metabolic,
anticholinergic, and sedating effects?
-pines
\.Antipsychotics with the most hyperprolactinemic and EPS effects?
-dones
\.Antipsychotics with most hypotensive effects and QT prolongation?
-pines, -ones (except Lurasidone)
\.Antipsychotics associated with the most akathisia?
-pips, -rip
\.Antipsychotics with the least cardiometabolic and sedation effects?
-pips, -rips, -dones
\.Antipsychotics associated with the least hypotensive side effects and QT prolongation?
-pips, -rips, Lurasidone
\.Antipsychotic(s) associated with comorbid anxiety and depression?
Quetiapine (Seroquel)
\,Antipsychotic(s) that must be taken with food?
Ziprasidone and Lurasidone
\.Antipsychotic that acts as a 5HT2A inverse agonist with no direct D2 receptor activity and is
approved to treat Parkinsonian Psychosis?
