APHON Chemotherapy Overview Exam
Questions and Answers (Most Recent
Version, Complete Study Material)
Pre-clinical Studies - Correct Answers ✅purpose is to
determine safe starting dose for humans
Folic Acid - Correct Answers ✅Positive effect on kids w/
lymphoblastic leukemia
Clinical trials - Correct Answers ✅comparing 2+
therapeutic tx in ctl setting to evaluate effect of intervention
of specific disease/s
Clinical Trial phase 1 - Correct Answers ✅how much can
you handle before breakdown?
determine max tolerated dose of drug or drug combo.
ID dose-limiting toxicities: highest dose for which incidence of
dose limiting toxicities is <33%
Clinical Trial Phase 1 Patient - Correct Answers ✅advanced
disease, good organ function, resistant to standard therapies
Clinical Trial phase 2 - Correct Answers ✅determines
efficacy of new agent in tx of specific cancer types and
validate toxicity & dosage data. info r/t drug administration,
acute toxicity, & supporting care
, APHON Chemotherapy Overview Exam
Questions and Answers (Most Recent
Version, Complete Study Material)
Clinical Trial phase 2 Patient - Correct Answers ✅pt who
show little to no response to prior tx usually selected w/
normal organ function, measurable tumor size, reasonable
life expectancy & functional status.
Includes pt who have not been treated w/ investigational drug
Clinical Trial Phase 3 - Correct Answers ✅determine value
of agent r/t existing tx. Measure response, toxicity, survival &
QOL
Clinical trial Phase 3 Patient - Correct Answers ✅large
number of newly dx who receive tx and observed over long
period of time
Clinical Trial Phase 4 - Correct Answers ✅Occurs after
agent is available in commercial market. Efforts to decrease
AE, toxicity w/ acceptable cure rate. Focuses more on long
term safety
Institutional Review Board - Correct Answers ✅Ensures the
rights/welfare of humans are protected, by signing informed
consent and requires documentation of eligibility, tx,
modifications, toxicities, and outcome
Questions and Answers (Most Recent
Version, Complete Study Material)
Pre-clinical Studies - Correct Answers ✅purpose is to
determine safe starting dose for humans
Folic Acid - Correct Answers ✅Positive effect on kids w/
lymphoblastic leukemia
Clinical trials - Correct Answers ✅comparing 2+
therapeutic tx in ctl setting to evaluate effect of intervention
of specific disease/s
Clinical Trial phase 1 - Correct Answers ✅how much can
you handle before breakdown?
determine max tolerated dose of drug or drug combo.
ID dose-limiting toxicities: highest dose for which incidence of
dose limiting toxicities is <33%
Clinical Trial Phase 1 Patient - Correct Answers ✅advanced
disease, good organ function, resistant to standard therapies
Clinical Trial phase 2 - Correct Answers ✅determines
efficacy of new agent in tx of specific cancer types and
validate toxicity & dosage data. info r/t drug administration,
acute toxicity, & supporting care
, APHON Chemotherapy Overview Exam
Questions and Answers (Most Recent
Version, Complete Study Material)
Clinical Trial phase 2 Patient - Correct Answers ✅pt who
show little to no response to prior tx usually selected w/
normal organ function, measurable tumor size, reasonable
life expectancy & functional status.
Includes pt who have not been treated w/ investigational drug
Clinical Trial Phase 3 - Correct Answers ✅determine value
of agent r/t existing tx. Measure response, toxicity, survival &
QOL
Clinical trial Phase 3 Patient - Correct Answers ✅large
number of newly dx who receive tx and observed over long
period of time
Clinical Trial Phase 4 - Correct Answers ✅Occurs after
agent is available in commercial market. Efforts to decrease
AE, toxicity w/ acceptable cure rate. Focuses more on long
term safety
Institutional Review Board - Correct Answers ✅Ensures the
rights/welfare of humans are protected, by signing informed
consent and requires documentation of eligibility, tx,
modifications, toxicities, and outcome
