GMS 6540 HOMEWORK EXAM
QUESTIONS & VERIFIED CORRECT
ANSWERS
Genetic changes are required for which of the following to occur? Select all that apply. - correct
answer ✔✔Initiation/Transformation of a cell
Formation of a malignant tumor from a pre-neoplastic lesion
Formation of clinical cancer from a malignant tumor
Metastasis of a clinical cancer
What effect would a G12V mutation in Ras have on ERK? - correct answer ✔✔It would lead to
increased activation of ERK
Are cancers more likely to develop mutation that activate or inactivate Rb? - correct answer
✔✔Inactivate
Metabolites of nicotine commonly result in DNA point mutations. Which type of DNA instability
is this an example of? - correct answer ✔✔Genetic instability
If a human cell underwent endoreduplication followed by failed cytokinesis, how many
chromosomes would you expect that cell to now contain? - correct answer ✔✔184
Which of the following statements is true regarding apoptosis. - correct answer ✔✔Cancer cells
must avoid it
Which statement best describes the Warburg effect? - correct answer ✔✔The switching of
cancer cells from oxidative phosphorylation to aerobic glycolysis
, A patient undergoes an FdG-PET scan. Will a tumor contain more or less 18fluorodeoxyglucose
than normal the surrounding tissue? - correct answer ✔✔More
Angiogenesis is __________________. - correct answer ✔✔the process of creating new blood
vessels from current blood vessels
Is inflammation harmful or beneficial to cancer? - correct answer ✔✔Beneficial
If a cell expresses a mutant form of EGFR, would this be considered a tumor specific antigen or a
tumor associated antigen? - correct answer ✔✔Tumor specific antigen
Which statement best describes how cancer cells overcome the Hayflick limit? - correct answer
✔✔They upregulate telomerase
What chemical causes the most cigarette-related DNA mutations? - correct answer
✔✔Benzo[a]pyrene
The Epstein-Barr virus, most famous for causing mononucleosis, also plays a prevalent role in
the formation of what type of cancer? - correct answer ✔✔Burkitt's lymphoma
What viral protein is capable of inhibiting p53? - correct answer ✔✔E6
Which class of cancer drugs is the least selective towards cancer cells? - correct answer
✔✔Chemotherapy
Is chemotherapy generally more effective when tumors are small or large? - correct answer
✔✔Small
QUESTIONS & VERIFIED CORRECT
ANSWERS
Genetic changes are required for which of the following to occur? Select all that apply. - correct
answer ✔✔Initiation/Transformation of a cell
Formation of a malignant tumor from a pre-neoplastic lesion
Formation of clinical cancer from a malignant tumor
Metastasis of a clinical cancer
What effect would a G12V mutation in Ras have on ERK? - correct answer ✔✔It would lead to
increased activation of ERK
Are cancers more likely to develop mutation that activate or inactivate Rb? - correct answer
✔✔Inactivate
Metabolites of nicotine commonly result in DNA point mutations. Which type of DNA instability
is this an example of? - correct answer ✔✔Genetic instability
If a human cell underwent endoreduplication followed by failed cytokinesis, how many
chromosomes would you expect that cell to now contain? - correct answer ✔✔184
Which of the following statements is true regarding apoptosis. - correct answer ✔✔Cancer cells
must avoid it
Which statement best describes the Warburg effect? - correct answer ✔✔The switching of
cancer cells from oxidative phosphorylation to aerobic glycolysis
, A patient undergoes an FdG-PET scan. Will a tumor contain more or less 18fluorodeoxyglucose
than normal the surrounding tissue? - correct answer ✔✔More
Angiogenesis is __________________. - correct answer ✔✔the process of creating new blood
vessels from current blood vessels
Is inflammation harmful or beneficial to cancer? - correct answer ✔✔Beneficial
If a cell expresses a mutant form of EGFR, would this be considered a tumor specific antigen or a
tumor associated antigen? - correct answer ✔✔Tumor specific antigen
Which statement best describes how cancer cells overcome the Hayflick limit? - correct answer
✔✔They upregulate telomerase
What chemical causes the most cigarette-related DNA mutations? - correct answer
✔✔Benzo[a]pyrene
The Epstein-Barr virus, most famous for causing mononucleosis, also plays a prevalent role in
the formation of what type of cancer? - correct answer ✔✔Burkitt's lymphoma
What viral protein is capable of inhibiting p53? - correct answer ✔✔E6
Which class of cancer drugs is the least selective towards cancer cells? - correct answer
✔✔Chemotherapy
Is chemotherapy generally more effective when tumors are small or large? - correct answer
✔✔Small
