Hemolytic Anemia Test Questions and Answers
Define Hemolytic Anemia - -A form of •Non-Immune - -•Mechanical; Heart valves,
anemia due to hemolysis, the abnormal DIC, TTP, HUS
breakdown of red blood cells (RBCs), either in •Physiochemical damage; Burns, oxidative
the blood vessels (intravascular hemolysis) or damage
elsewhere in the human body (extravascular). •Membrane abnormalities; Paroxysmal nocturnal
hemoglobinuria
Increased _____ is seen in hemolytic anemia. -
-bone marrow production of RBC Initial Laboratory Evaluation of Bone Marrow
Production - -1. Reticulocyte count
2. Bone marrow cellularity
Anemia develops when.... - -The bone
marrow cannot compensate for RBC destruction
Initial Laboratory Evaluation of Red Blood Cell
Circulation - -1. Hemoglobin
Hereditary Disorders 2. Hematocrit
•Membrane Defects - -•Hereditary
spherocytosis
•Hereditary elliptocytosis Initial Laboratory Evaluation of Red Blood Cell
Sequestration - -51Cr sequestration
Hereditary Disorders
•Abnormal RBC enzymes - -•G6PD Initial Laboratory Evaluation of Red Blood Cell
deficiency Breakdown - -1. Haptoglobin
•Glycolytic pathway 2. Bilirubin
•Glutathione pathway 3. Lactate dehydrogenase
4. Hemoglobinemia
5. Methemoglobinemia
Hereditary Disorders 6. Bone marrow iron
•Hemoglobin synthesis - -•Quantitative
(decreased); Thalassemias
•Qualitative (abnormal); Hemoglobin S, Initial Laboratory Evaluation of Excretion - -
Hemoglobin C, Hemoglobin E 1. Hemosiderinuria
2. Hemoglobinuria
Acquired Disorders
•Immune - -•Infections; Mycoplasma, Indirect Bilirubin, serum is ______ early in
malaria, Clostridium perfringens hemolysis (Rule out Crigler-Najjar, Gilbert's). -
•Alloantibodies; Maternal fetal incompatibilities, -Increased
transfusions
•Autoantibodies; Collagen vascular disorders,
lymphomas, drugs, idiopathic Laboratory Findings of Haptoglobin in plasma. -
-heme binds to haptoglobin, transferrin,
albumin; elevated in inflammation (hinders
Acquired Disorders usefulness)
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Define Hemolytic Anemia - -A form of •Non-Immune - -•Mechanical; Heart valves,
anemia due to hemolysis, the abnormal DIC, TTP, HUS
breakdown of red blood cells (RBCs), either in •Physiochemical damage; Burns, oxidative
the blood vessels (intravascular hemolysis) or damage
elsewhere in the human body (extravascular). •Membrane abnormalities; Paroxysmal nocturnal
hemoglobinuria
Increased _____ is seen in hemolytic anemia. -
-bone marrow production of RBC Initial Laboratory Evaluation of Bone Marrow
Production - -1. Reticulocyte count
2. Bone marrow cellularity
Anemia develops when.... - -The bone
marrow cannot compensate for RBC destruction
Initial Laboratory Evaluation of Red Blood Cell
Circulation - -1. Hemoglobin
Hereditary Disorders 2. Hematocrit
•Membrane Defects - -•Hereditary
spherocytosis
•Hereditary elliptocytosis Initial Laboratory Evaluation of Red Blood Cell
Sequestration - -51Cr sequestration
Hereditary Disorders
•Abnormal RBC enzymes - -•G6PD Initial Laboratory Evaluation of Red Blood Cell
deficiency Breakdown - -1. Haptoglobin
•Glycolytic pathway 2. Bilirubin
•Glutathione pathway 3. Lactate dehydrogenase
4. Hemoglobinemia
5. Methemoglobinemia
Hereditary Disorders 6. Bone marrow iron
•Hemoglobin synthesis - -•Quantitative
(decreased); Thalassemias
•Qualitative (abnormal); Hemoglobin S, Initial Laboratory Evaluation of Excretion - -
Hemoglobin C, Hemoglobin E 1. Hemosiderinuria
2. Hemoglobinuria
Acquired Disorders
•Immune - -•Infections; Mycoplasma, Indirect Bilirubin, serum is ______ early in
malaria, Clostridium perfringens hemolysis (Rule out Crigler-Najjar, Gilbert's). -
•Alloantibodies; Maternal fetal incompatibilities, -Increased
transfusions
•Autoantibodies; Collagen vascular disorders,
lymphomas, drugs, idiopathic Laboratory Findings of Haptoglobin in plasma. -
-heme binds to haptoglobin, transferrin,
albumin; elevated in inflammation (hinders
Acquired Disorders usefulness)
1/4
