Lecture 46
Cell Communication and Signalling
Dr. Derek Brazil
Wellcome-Wolfson Institute for Experimental Medicine
QUB
(Preferred Pronouns: He/Him)
C25 Fo
Lectur
Year 1
21/10/
, Lecture 46-Learning Outcomes
• Be able to define the terms cell communication, cell signalling and signal tra
• Be able to define the different forms of cell communication
• Describe the mechanisms of G-protein coupled receptor (GPCR) signalling,
and the role of G-proteins
• Explain what second messengers are, with examples such as cAMP
• Identify how Receptor Tyrosine kinase signalling functions, and the role of
tyrosine phosphorylation
• Provide details of human diseases where cell communication is defective
• Be able to list other forms of cell signalling such as steroid hormone and
nitric oxide (NO) signalling
Reference: Chapter 16 Essential Cell Biology, 5th Ed.
, Cells are involved in constant communicati
Basic Problem for all organisms:
How to sense, interpret and integrate signals from their environme
into biological responses?
barrage of information from Response
the extracellular milieu Cell
e.g. die, grow,
Stick together, move
, Cell Communication and Signalling in
unicellular organisms (bacteria)
-Unicellular organisms (2.5 x 109 years before multi-cellular
organisms appeared)
short Responses
peptides Grow/divide
Die
Escape from immun
Cell Communication and Signalling
Dr. Derek Brazil
Wellcome-Wolfson Institute for Experimental Medicine
QUB
(Preferred Pronouns: He/Him)
C25 Fo
Lectur
Year 1
21/10/
, Lecture 46-Learning Outcomes
• Be able to define the terms cell communication, cell signalling and signal tra
• Be able to define the different forms of cell communication
• Describe the mechanisms of G-protein coupled receptor (GPCR) signalling,
and the role of G-proteins
• Explain what second messengers are, with examples such as cAMP
• Identify how Receptor Tyrosine kinase signalling functions, and the role of
tyrosine phosphorylation
• Provide details of human diseases where cell communication is defective
• Be able to list other forms of cell signalling such as steroid hormone and
nitric oxide (NO) signalling
Reference: Chapter 16 Essential Cell Biology, 5th Ed.
, Cells are involved in constant communicati
Basic Problem for all organisms:
How to sense, interpret and integrate signals from their environme
into biological responses?
barrage of information from Response
the extracellular milieu Cell
e.g. die, grow,
Stick together, move
, Cell Communication and Signalling in
unicellular organisms (bacteria)
-Unicellular organisms (2.5 x 109 years before multi-cellular
organisms appeared)
short Responses
peptides Grow/divide
Die
Escape from immun
