Cytoskeleton Function and the Cilia

Lecture 15
The Cell:Cytoskeleton/Cilia
Dr. Derek P. Brazil
Wellcome-Wolfson Institute for Experimental Medicine
Queen’s University Belfast

(Preferred Pronouns: He/Him)

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, Lecture 15-Learning Outcomes

1. Explain the dynamic structure of cells and the role of the cytoskeleton
2. Provide details on the three types of cytoskeletal filaments
3. Recognise that intermediate filaments control cell strength and nuclear
integrity
4. Define microtubule expansion and contraction and their connection to
centromere
5. Identify how microtubules are critical to the function of cilia in cells
6. Understand how microtubules are drug targets in different human dise
7. Recall that actin filaments regulate the cell cortex and cell movement u
ATP
8. Explain the importance of defects in cytoskeletal proteins in medicine

Reference: Chapter 17 Essential Cell Biology, 4th Ed.

, What is the cytoskeleton?
“an intricate network of protein filaments that extends throughout the cyto
Role of the cytoskeleton:
-strength and support to cell
-allows cell shape changes
-cell movement (sperm)
-cell contraction (muscles)
-wound healing
-cell division (mitosis/meoisis)
-interaction with other cells
-organisation of cell interior


“bones and muscles of the cell” Cytoskeleton in act

, Cytoskeleton and human disease
-defects in cytoskeletal proteins can have catastrophic consequences for p

Epidermolysis Bullosa Progeria




-caused by defects in keratin -caused by defects in nuclear la
(and also collagen)