Lecture 08
The Cell: The Basics
Dr. Derek P. Brazil
Wellcome-Wolfson Institute for Experimental Medicine
Queen’s University Belfast
(Preferred Pronouns: He/Him)
, Lecture 08-Learning Outcomes
• Appreciate how medical treatments have developed throughout his
• Recognize that mammalian cells vary in appearance and function
• Describe the features of eukaryotic cells and the building blocks th
make up cells
• Recognize the importance of genes and molecules in biology and
medicine
• Discuss the idea of cellular compartments and metabolic pathways
• Appreciate that the inside of a cell is different from the outside
• Describe the concept of cellular homeostasis
Reading Material: Essential Cell Biology 5th Ed. Chapter 1
,Infantile onset encephalomyopathy mitochondria
DNA depletion syndrome (MDDS)
• autosomal recessive disorder
• genetic mutation that reduces the amount of mit
DNA in muscle, liver and brain-symptoms: profo
weakness, encephalopathy, seizures, liver failur
• genes mutated include TK2 (myopathic),POLG
(hepatocerebral) and SUCLA2 (encephalomyop
• develops postnatally, usually fatal
, Health and disease: an historical perspec
The Cell: The Basics
Dr. Derek P. Brazil
Wellcome-Wolfson Institute for Experimental Medicine
Queen’s University Belfast
(Preferred Pronouns: He/Him)
, Lecture 08-Learning Outcomes
• Appreciate how medical treatments have developed throughout his
• Recognize that mammalian cells vary in appearance and function
• Describe the features of eukaryotic cells and the building blocks th
make up cells
• Recognize the importance of genes and molecules in biology and
medicine
• Discuss the idea of cellular compartments and metabolic pathways
• Appreciate that the inside of a cell is different from the outside
• Describe the concept of cellular homeostasis
Reading Material: Essential Cell Biology 5th Ed. Chapter 1
,Infantile onset encephalomyopathy mitochondria
DNA depletion syndrome (MDDS)
• autosomal recessive disorder
• genetic mutation that reduces the amount of mit
DNA in muscle, liver and brain-symptoms: profo
weakness, encephalopathy, seizures, liver failur
• genes mutated include TK2 (myopathic),POLG
(hepatocerebral) and SUCLA2 (encephalomyop
• develops postnatally, usually fatal
, Health and disease: an historical perspec
