Summary Gouty Arthritis and Pseudogout: Etiology, Pathophysiology, and Management

GOUTY ARTHRITIS Robert Langat

,DEFINITION
It’s a hereditary condition of disturbed uric acid
metabolism in which urate salts gets deposited in
articular , peri articular and subcutaneous tissues
Its clinically by recurring attacks of acute arthritis by
interval of freedom from pain and in late stages by
deforming arthritis, nephritis and urinary calculi.

,PREDISPOSING FACTORS
Alcohol abuse Hyperlipidemia
High consumption of Chronic inflammatory
red meat and beans disease
Obesity Long term of use of
Diabetes diuretic's or aspirin
Hypertension Hyper parathyroidism
Myeloproliferative
disorders

, ETIOLOGY
Idiopathic.
Hereditary : family members have hyperuricemia without
gout.
Race: Whites > Blacks.
Sex : Males > Females.
Age : 2nd to 4th decade , common at 40 years.
Adrenal cortex insufficiency : an adequate amount of
corticosteroids counteracts the gouty attack.
Disturbed electrolyte equilibrium : Marked diuresis that
precedes acute attacks of gout.