Connective tissue diseases (Smarty PANCE) Questions and
Answers
What are connective tissue diseases (CTDs)?- polymyositis?- Anti-Jo-1
A group of autoimmune or inherited
disorders affecting structural proteins like What lab values are elevated in polymyositis?-
collagen and elastin Creatine kinase and aldolase
What are the two main types of CTDs?- What are hallmark signs of dermatomyositis?-
Autoimmune and inherited Heliotrope rash and Gottron papules
Which CTDs are autoimmune in origin?- What autoantibody is most specific for RA?-
SLE, systemic sclerosis, Sjögren Anti-CCP
syndrome, RA, polymyositis, dermatomyositis,
APS, Behçet’s, relapsing polychondritis, MCTD, Which clinical feature is characteristic of RA?-
UCTD Symmetric polyarthritis of small joints
Which CTDs are inherited?- Ehlers-Danlos What is the diagnostic hallmark of
syndromes and Marfan syndrome antiphospholipid syndrome (APS)?- Positive
anticardiolipin, lupus anticoagulant, or beta-2
What autoantibody is most sensitive for SLE?- glycoprotein I
ANA
What clinical triad is associated with APS?-
Which antibody is highly specific for SLE?- Thrombosis, recurrent miscarriage, and
Anti-dsDNA or anti-Smith thrombocytopenia
What are classic cutaneous findings in SLE?- What is the pathognomonic triad for Behçet’s
Malar rash and photosensitivity disease?- Oral ulcers, genital ulcers, and
uveitis
Which antibody is specific for systemic
sclerosis?- Anti-Scl-70 (anti-topoisomerase What is relapsing polychondritis?- An
I) inflammatory disorder causing recurrent cartilage
inflammation in the ears, nose, and airway
Which antibody is associated with limited
cutaneous systemic sclerosis?- Anti- Which antibody is found in mixed connective
centromere tissue disease (MCTD)?- Anti-U1 RNP
What symptoms are associated with Sjögren What defines undifferentiated connective tissue
syndrome?- Dry eyes and dry mouth (sicca disease (UCTD)?- Symptoms suggestive of
symptoms) CTD but not fulfilling criteria for any specific one
Which antibodies are associated with Sjögren What is an overlap syndrome?-
syndrome?- Anti-Ro (SSA) and anti-La Coexistence of features from ≥ 2
(SSB) autoimmune CTDs and may include
combinations such as SLE and RA (rheumatoid
What antibodies are associated with arthritis), or systemic sclerosis and myositis
1/2
Answers
What are connective tissue diseases (CTDs)?- polymyositis?- Anti-Jo-1
A group of autoimmune or inherited
disorders affecting structural proteins like What lab values are elevated in polymyositis?-
collagen and elastin Creatine kinase and aldolase
What are the two main types of CTDs?- What are hallmark signs of dermatomyositis?-
Autoimmune and inherited Heliotrope rash and Gottron papules
Which CTDs are autoimmune in origin?- What autoantibody is most specific for RA?-
SLE, systemic sclerosis, Sjögren Anti-CCP
syndrome, RA, polymyositis, dermatomyositis,
APS, Behçet’s, relapsing polychondritis, MCTD, Which clinical feature is characteristic of RA?-
UCTD Symmetric polyarthritis of small joints
Which CTDs are inherited?- Ehlers-Danlos What is the diagnostic hallmark of
syndromes and Marfan syndrome antiphospholipid syndrome (APS)?- Positive
anticardiolipin, lupus anticoagulant, or beta-2
What autoantibody is most sensitive for SLE?- glycoprotein I
ANA
What clinical triad is associated with APS?-
Which antibody is highly specific for SLE?- Thrombosis, recurrent miscarriage, and
Anti-dsDNA or anti-Smith thrombocytopenia
What are classic cutaneous findings in SLE?- What is the pathognomonic triad for Behçet’s
Malar rash and photosensitivity disease?- Oral ulcers, genital ulcers, and
uveitis
Which antibody is specific for systemic
sclerosis?- Anti-Scl-70 (anti-topoisomerase What is relapsing polychondritis?- An
I) inflammatory disorder causing recurrent cartilage
inflammation in the ears, nose, and airway
Which antibody is associated with limited
cutaneous systemic sclerosis?- Anti- Which antibody is found in mixed connective
centromere tissue disease (MCTD)?- Anti-U1 RNP
What symptoms are associated with Sjögren What defines undifferentiated connective tissue
syndrome?- Dry eyes and dry mouth (sicca disease (UCTD)?- Symptoms suggestive of
symptoms) CTD but not fulfilling criteria for any specific one
Which antibodies are associated with Sjögren What is an overlap syndrome?-
syndrome?- Anti-Ro (SSA) and anti-La Coexistence of features from ≥ 2
(SSB) autoimmune CTDs and may include
combinations such as SLE and RA (rheumatoid
What antibodies are associated with arthritis), or systemic sclerosis and myositis
1/2
