Acromegaly and gigantism (Smarty PANCE) Test Questions and
Answers Rated A
What is the most common cause of gigantism excessive secretion of pituitary GH may be due
and acromegaly?- Gigantism and to a non-CNS tumor producing excessive
acromegaly are usually caused by a pituitary amounts of ectopic GHRH.
adenoma that secretes excessive amounts of
Growth Hormone (GH). Rarely, they are caused What happens to serum growth hormone levels
by non-pituitary tumors that secrete GHRH. after oral glucose tolerance test in patients with
acromegaly?- Serum growth hormone
What differentiates gigantism from acromegaly?- levels remain high after oral glucose tolerance
Gigantism occurs if growth hormone test in patients with acromegaly
hypersecretion begins in childhood, before the
closure of the epiphyses. Acromegaly involves In patients with gigantism, does obesity occur
growth hormone hypersecretion beginning in before or after the onset of increased height?-
adulthood; a variety of bony and soft tissue In patients with gigantism, obesity usually
abnormalities develop. Remember Acromegaly occurs after the onset of increased height
has an "A" for adulthood!
What medication is used in acromegaly to inhibit
Describe acromegaly? - Acromegaly is a the release of growth hormone if tumors cannot
complication of a growth hormone adenoma be removed? - The somatostatin analog,
seen in adults and involves enlarged bones, octreotide is used in acromegaly to inhibit the
visceral organs, and tongue. release of growth hormone
How does acromegaly causes affect glucose How does gigantism affect glucose? - As
levels?- Acromegaly causes increased patients with gigantism have increased growth
glucose levels hormone levels, this causes the liver to release
more glucose levels into the blood and patients
Is gigantism an adult or childhood disorder?- can theoretically present with hyperglycemia
Gigantism is a childhood disorder
What is the growth hormone receptor antagonist
What is the most sensitive diagnostic test for used to treat acromegaly?- Pegvisomant is
diagnosing acromegaly?- The most a growth hormone receptor antagonist used to
sensitive diagnostic test for diagnosing treat acromegaly
acromegaly is serum insulin-like growth factor-1
How does gigantism affect blood insulin levels? -
What is the best initial test for diagnosing GH increases insulin resistance which
gigantism?- The best initial test for leads to an increase in blood insulin levels
diagnosing gigantism is measuring insulin-like
growth factor What is the most common cause of death in
patients with acromegaly?- Dilated
How does acromegaly affect Insulin sensitivity?- cardiomyopathy is the most common cause of
Insulin sensitivity decreases in acromegaly death in patients with acromegaly
What additional testing should be done? - What is the equivalent of acromegaly that is seen
CT or MRI of the head should be done to in children?- The equivalent of acromegaly
look for a tumor. If a tumor is not visible, seen in adults is gigantism seen in children
1/2
Answers Rated A
What is the most common cause of gigantism excessive secretion of pituitary GH may be due
and acromegaly?- Gigantism and to a non-CNS tumor producing excessive
acromegaly are usually caused by a pituitary amounts of ectopic GHRH.
adenoma that secretes excessive amounts of
Growth Hormone (GH). Rarely, they are caused What happens to serum growth hormone levels
by non-pituitary tumors that secrete GHRH. after oral glucose tolerance test in patients with
acromegaly?- Serum growth hormone
What differentiates gigantism from acromegaly?- levels remain high after oral glucose tolerance
Gigantism occurs if growth hormone test in patients with acromegaly
hypersecretion begins in childhood, before the
closure of the epiphyses. Acromegaly involves In patients with gigantism, does obesity occur
growth hormone hypersecretion beginning in before or after the onset of increased height?-
adulthood; a variety of bony and soft tissue In patients with gigantism, obesity usually
abnormalities develop. Remember Acromegaly occurs after the onset of increased height
has an "A" for adulthood!
What medication is used in acromegaly to inhibit
Describe acromegaly? - Acromegaly is a the release of growth hormone if tumors cannot
complication of a growth hormone adenoma be removed? - The somatostatin analog,
seen in adults and involves enlarged bones, octreotide is used in acromegaly to inhibit the
visceral organs, and tongue. release of growth hormone
How does acromegaly causes affect glucose How does gigantism affect glucose? - As
levels?- Acromegaly causes increased patients with gigantism have increased growth
glucose levels hormone levels, this causes the liver to release
more glucose levels into the blood and patients
Is gigantism an adult or childhood disorder?- can theoretically present with hyperglycemia
Gigantism is a childhood disorder
What is the growth hormone receptor antagonist
What is the most sensitive diagnostic test for used to treat acromegaly?- Pegvisomant is
diagnosing acromegaly?- The most a growth hormone receptor antagonist used to
sensitive diagnostic test for diagnosing treat acromegaly
acromegaly is serum insulin-like growth factor-1
How does gigantism affect blood insulin levels? -
What is the best initial test for diagnosing GH increases insulin resistance which
gigantism?- The best initial test for leads to an increase in blood insulin levels
diagnosing gigantism is measuring insulin-like
growth factor What is the most common cause of death in
patients with acromegaly?- Dilated
How does acromegaly affect Insulin sensitivity?- cardiomyopathy is the most common cause of
Insulin sensitivity decreases in acromegaly death in patients with acromegaly
What additional testing should be done? - What is the equivalent of acromegaly that is seen
CT or MRI of the head should be done to in children?- The equivalent of acromegaly
look for a tumor. If a tumor is not visible, seen in adults is gigantism seen in children
1/2
