APHON PRINCIPLES OF CHEMO AND BIOTHERAPY
EXAM QUESTIONS AND ANSWERS 100% CORRECT!!
, Biotherapy - ANSWER Targeted anticancer agents also known as biological response
modifiers (BRM)
Tyrosine kinase inhibitors (TKIs) are what class - ANSWER Biotherapy
Monoclonal antibodies (MoAbs) are what class - ANSWER Biotherapy
Define pharmacokinetics - ANSWER Study of drug absorption, metabolism, and
excretion
Define pharmacodynamics - ANSWER The concentration of the drug in the body and
how it produces a response
Define adjuvant chemotherapy - ANSWER The use of chemo after another type of
therapy, such as surgery, to treat residual disease or undetectable metastasis.
Define neoadjuvant chemotherapy - ANSWER When chemo is used preoperatively to
decrease tumor burden in order to make it easier to remove the tumor surgically.
Define sanctuary sites - ANSWER Sites within the body where tumor cells sequester
and are not easily reached by chemo such as the CNS
What normal cells are most often effected by chemotherapy - ANSWER Hematopoietic,
mucosal (mouth & GI), hair follicles
Why use chemotherapy - ANSWER To prevent cancer cells from dividing,
metastasizing, and ultimately causing the death of the patient
Cure - ANSWER To permanently eradicate the cancer
Control - ANSWER To extend the length & QOL when cure is not feasible or realistic
Palliation - ANSWER Minimize pain and suffering during end of life
Resting phase of cell cycle - ANSWER Gap 0 - cells not dividing
EXAM QUESTIONS AND ANSWERS 100% CORRECT!!
, Biotherapy - ANSWER Targeted anticancer agents also known as biological response
modifiers (BRM)
Tyrosine kinase inhibitors (TKIs) are what class - ANSWER Biotherapy
Monoclonal antibodies (MoAbs) are what class - ANSWER Biotherapy
Define pharmacokinetics - ANSWER Study of drug absorption, metabolism, and
excretion
Define pharmacodynamics - ANSWER The concentration of the drug in the body and
how it produces a response
Define adjuvant chemotherapy - ANSWER The use of chemo after another type of
therapy, such as surgery, to treat residual disease or undetectable metastasis.
Define neoadjuvant chemotherapy - ANSWER When chemo is used preoperatively to
decrease tumor burden in order to make it easier to remove the tumor surgically.
Define sanctuary sites - ANSWER Sites within the body where tumor cells sequester
and are not easily reached by chemo such as the CNS
What normal cells are most often effected by chemotherapy - ANSWER Hematopoietic,
mucosal (mouth & GI), hair follicles
Why use chemotherapy - ANSWER To prevent cancer cells from dividing,
metastasizing, and ultimately causing the death of the patient
Cure - ANSWER To permanently eradicate the cancer
Control - ANSWER To extend the length & QOL when cure is not feasible or realistic
Palliation - ANSWER Minimize pain and suffering during end of life
Resting phase of cell cycle - ANSWER Gap 0 - cells not dividing
