APHON CHEMO CERTIFICATION EXAM QUESTIONS AND ANSWERS 100% CORRECT!!

What is the 5 yr survival rate for all peds onc diagnoses? For ALL? For AML? - ANSWER All Dx: > 80% ALL: 90% AML: 65% Natural cell death - ANSWER Apoptosis Cell death from an insult that leads to rupture of the cell membrane and spilling of cell contents - ANSWER Necrosis Regulates normal cell growth and repair - ANSWER Proto-oncogenes Blood cell production - ANSWER Hematopoiesis Period of time when the pt's WBCs are the lowest, from day 7-10 - ANSWER Nadir What time is when a pt is at the greatest risk for infection - ANSWER During Nadir Goal of chemo - ANSWER Stop cell cycle/growth from occurring and coming back Why are multiple chemo agents used? - ANSWER Resistance to a single chemo agent can occur Chemo cells OUT of bone marrow and in the peripheral system - ANSWER Blasts Chemotherapy affects 4 things - ANSWER 1. Malignant cells 2. Epidermal 3. Bone Marrow 4. Epithelial lining S/S of Childhood Cancer - ANSWER fever, HA, n/v, fatigue, pain, petechiae, pallor, changes in gait, pancytopenia, lymphadenopathy, night sweats, hematuria, anorexia, abdominal or extremity mass The study of how a person's genetic makeup affects that person's response to drug therapy - ANSWER Pharmacogenetics Modalities of Therapy (5) - ANSWER 1. Surgery 2. Chemotherapy 3. Radiation 4. Hematopoietic Stem Cell Transplantation (HSCT) 5. Biologic Therapy 3 Goals of chemotherapy - ANSWER 1. cure 2. control 3. palliation Goal of surgical therapy - ANSWER reduce tumor burden