The Immune System – 4th
ST
Edition
UV
TEST BANK
IA
?_
AP
Peter Parham
PR
Comprehensive Test Bank for Instructors
OV
and Students
ED
© Peter Parham
All rights reserved. Reproduction or distribution without permission is prohibited.
?
Created by MedConnoisseur ©2025/2026
, TABLE OF CONTENTS
The Immune System – 4th Edition
ST
Peter Parham
UV
1. Elements of the Immune System and Their Roles in Defense
2. Innate Immunity: The Immediate Response to Infection
3. Innate Immunity: The Induced Response to Infection
4. Antibody Structure and the Generation of B-Cell Diversity
5. Antigen Recognition by T Lymphocytes
IA
6. The Development of B Lymphocytes
7. The Development of T Lymphocytes
8. T Cell–Mediated Immunity
?_
9. Immunity Mediated by B Cells and Antibodies
10.Preventing Infection at Mucosal Surfaces
11.Immunological Memory and Vaccination
AP
12.Coevolution of Innate and Adaptive Immunity
13.Failures of the Body’s Defenses
14.IgE-Mediated Immunity and Allergy
15.Transplantation of Tissues and Organs
PR
16.Disruption of Healthy Tissue by the Adaptive Immune Response
17.Cancer and Its Interactions with the Immune System
OV
ED
?
Created by MedConnoisseur ©2025/2026
, THE IMMUNE SYSTEM, FOURTH EDITION
CHAPTER 1: ELEMENTS OF THE IMMUNE SYSTEM
ST
AND THEIR ROLES IN DEFENSE
© 2015 GARLAND SCIENCE
UV
1–1 The last cases of smallpox were reported in the _____.
a. 1950s
b. 1960s
c. 1970s
d. 1980s
e. 1990s.
IA
1–2 The first line of defense against microorganisms that infect the body is referred to as
_____.
a. opportunistic immunity
b. innate immunity
?_
c. adaptive immunity
d. primary immunity
e. central immunity.
AP
1–3 Which of the following pairs is mismatched?
a. innate immunity: highly specialized defenses
b. secondary immune response: immunological memory
c. hematopoiesis: bone marrow
d. phagocytosis: uptake and killing of microbes
e. lymphocyte recirculation: continuous transport between blood and lymph.
PR
1–4 All of the following are examples of chemical barriers of innate immunity except _____.
a. lactic acid
b. normal microbiota
c. lysozyme
OV
d. fatty acids
e. proteases.
1–5 When effector lymphocytes secrete _____, an inflammatory response ensues.
a. lysozyme
b. defensins
ED
c. lymph
d. sebum
e. cytokines.
1–6 The thin layer of cells that makes up the interior lining of the blood vessels is called the
_____.
?
a. mucosa
1
, b. epithelium
c. endothelium
d. connective tissue
ST
e. lymphoid tissue.
1–7 Identify the incorrect statement regarding hematopoiesis.
a. Hematopoiesis is a continuous process that occurs throughout one’s lifetime.
b. The location for hematopoiesis differs with age.
UV
c. Self renewal is necessary to replenish the supply of hematopoietic stem cells.
d. Most hematopoiesis occurs in the bone marrow after birth.
e. Leukocytes, but not erythrocytes, must go through hematopoiesis in order to develop.
1–8 The progenitors of macrophages are _____.
a. megakaryocytes
IA
b. dendritic cells
c. monocytes
d. neutrophils
e. erythrocytes
?_
f. M cells.
1–9 _____ act as cellular messengers by delivering degraded pathogens to lymphoid organs.
a. Plasma cells
b. Dendritic cells
AP
c. Large granular lymphocytes
d. Mast cells
e. Basophils.
1–10 Another name for a large granular lymphocyte is a _____.
a. plasma cell
PR
b. helper T cell
c. monocyte
d. natural killer cell
e. eosinophil.
OV
1–11 Effector cells that secrete antibodies are known as _____.
a. natural killer cells
b. cytotoxic T cells
c. helper T cells
d. M cells
e. plasma cells
ED
f. regulatory T cells.
1–12 Spherical regions in lymph nodes containing areas that are packed densely with
proliferating B cells are called _____.
a. efferent vessels
?
b. germinal centers
2
ST
Edition
UV
TEST BANK
IA
?_
AP
Peter Parham
PR
Comprehensive Test Bank for Instructors
OV
and Students
ED
© Peter Parham
All rights reserved. Reproduction or distribution without permission is prohibited.
?
Created by MedConnoisseur ©2025/2026
, TABLE OF CONTENTS
The Immune System – 4th Edition
ST
Peter Parham
UV
1. Elements of the Immune System and Their Roles in Defense
2. Innate Immunity: The Immediate Response to Infection
3. Innate Immunity: The Induced Response to Infection
4. Antibody Structure and the Generation of B-Cell Diversity
5. Antigen Recognition by T Lymphocytes
IA
6. The Development of B Lymphocytes
7. The Development of T Lymphocytes
8. T Cell–Mediated Immunity
?_
9. Immunity Mediated by B Cells and Antibodies
10.Preventing Infection at Mucosal Surfaces
11.Immunological Memory and Vaccination
AP
12.Coevolution of Innate and Adaptive Immunity
13.Failures of the Body’s Defenses
14.IgE-Mediated Immunity and Allergy
15.Transplantation of Tissues and Organs
PR
16.Disruption of Healthy Tissue by the Adaptive Immune Response
17.Cancer and Its Interactions with the Immune System
OV
ED
?
Created by MedConnoisseur ©2025/2026
, THE IMMUNE SYSTEM, FOURTH EDITION
CHAPTER 1: ELEMENTS OF THE IMMUNE SYSTEM
ST
AND THEIR ROLES IN DEFENSE
© 2015 GARLAND SCIENCE
UV
1–1 The last cases of smallpox were reported in the _____.
a. 1950s
b. 1960s
c. 1970s
d. 1980s
e. 1990s.
IA
1–2 The first line of defense against microorganisms that infect the body is referred to as
_____.
a. opportunistic immunity
b. innate immunity
?_
c. adaptive immunity
d. primary immunity
e. central immunity.
AP
1–3 Which of the following pairs is mismatched?
a. innate immunity: highly specialized defenses
b. secondary immune response: immunological memory
c. hematopoiesis: bone marrow
d. phagocytosis: uptake and killing of microbes
e. lymphocyte recirculation: continuous transport between blood and lymph.
PR
1–4 All of the following are examples of chemical barriers of innate immunity except _____.
a. lactic acid
b. normal microbiota
c. lysozyme
OV
d. fatty acids
e. proteases.
1–5 When effector lymphocytes secrete _____, an inflammatory response ensues.
a. lysozyme
b. defensins
ED
c. lymph
d. sebum
e. cytokines.
1–6 The thin layer of cells that makes up the interior lining of the blood vessels is called the
_____.
?
a. mucosa
1
, b. epithelium
c. endothelium
d. connective tissue
ST
e. lymphoid tissue.
1–7 Identify the incorrect statement regarding hematopoiesis.
a. Hematopoiesis is a continuous process that occurs throughout one’s lifetime.
b. The location for hematopoiesis differs with age.
UV
c. Self renewal is necessary to replenish the supply of hematopoietic stem cells.
d. Most hematopoiesis occurs in the bone marrow after birth.
e. Leukocytes, but not erythrocytes, must go through hematopoiesis in order to develop.
1–8 The progenitors of macrophages are _____.
a. megakaryocytes
IA
b. dendritic cells
c. monocytes
d. neutrophils
e. erythrocytes
?_
f. M cells.
1–9 _____ act as cellular messengers by delivering degraded pathogens to lymphoid organs.
a. Plasma cells
b. Dendritic cells
AP
c. Large granular lymphocytes
d. Mast cells
e. Basophils.
1–10 Another name for a large granular lymphocyte is a _____.
a. plasma cell
PR
b. helper T cell
c. monocyte
d. natural killer cell
e. eosinophil.
OV
1–11 Effector cells that secrete antibodies are known as _____.
a. natural killer cells
b. cytotoxic T cells
c. helper T cells
d. M cells
e. plasma cells
ED
f. regulatory T cells.
1–12 Spherical regions in lymph nodes containing areas that are packed densely with
proliferating B cells are called _____.
a. efferent vessels
?
b. germinal centers
2
