Page | 1
NBME 25 EXAM 2025/2026 BRAND
NEW QUESTIONS WITH ANSWERS|
ACE YOUR GRADES!
1. Cryoglobulinemia - correct answer -is a medical condition in
which the blood contains large amounts of cryoglobulins -
proteins (mostly immunoglobulins themselves) that become
insoluble at reduced temperatures.
2. Adrenogenital syndrome - correct answer -CAH
3. Maternal exposure to oral progestins - correct answer -
hypospadias
4. Pyruvate kinase: ATP and alanine - correct answer -inhibit it
5. Glycogen phosphorylase - correct answer -glycogenolysis
, Page | 2
6. Lymph from labia majora, vulva, scrotum, anal canal below
pectinate line drain into what lymph nodes - correct answer -
inguinal lymph nodes
7. Lymph from glans penis, clitoris, upper portion of vagina,
fundus of bladder - correct answer -external iliac lymph nodes
8. Lower rectum to anal canal (above pectinate line), bladder,
vagina (middle third), prostate lymph drainage - correct answer
-internal iliac lymph nodes
9. Tumor grading - correct answer -cellular and histologic features
of the tumor
10. Tumor staging - correct answer -size of primary tumor
11. Degree of involvement of regional lymph nodes, metastases
12. Rheumatoid arthritis effects on: TNF, IL-1, Segmented
Neutrophils, Complement (C3) - correct answer -all increased
except Complement which is used up and decreased
, Page | 3
13. Peptide transporter shuttles antigens into the ER so it can be
complexed with what - correct answer -MHC1
14. Bare Lymphocyte Syndrome Type I - correct answer -TAP
mutation (peptide transporter)
15. Autoimmune Lymphoproliferative Syndrome (ALPS) - correct
answer -mutation in either Fas ligand or Fas receptor
16. Baseline risk of a VSD - correct answer -2-3%
17. Inheritance of AD with one parent heterozygous or X-linked
recessive to sons of carrier mothers- % risk - correct answer -
50%
18. Zenker diverticulum location (2) - correct answer -between
cricopharyngeus and inferior pharyngeal constrictor muscle
NBME 25 EXAM 2025/2026 BRAND
NEW QUESTIONS WITH ANSWERS|
ACE YOUR GRADES!
1. Cryoglobulinemia - correct answer -is a medical condition in
which the blood contains large amounts of cryoglobulins -
proteins (mostly immunoglobulins themselves) that become
insoluble at reduced temperatures.
2. Adrenogenital syndrome - correct answer -CAH
3. Maternal exposure to oral progestins - correct answer -
hypospadias
4. Pyruvate kinase: ATP and alanine - correct answer -inhibit it
5. Glycogen phosphorylase - correct answer -glycogenolysis
, Page | 2
6. Lymph from labia majora, vulva, scrotum, anal canal below
pectinate line drain into what lymph nodes - correct answer -
inguinal lymph nodes
7. Lymph from glans penis, clitoris, upper portion of vagina,
fundus of bladder - correct answer -external iliac lymph nodes
8. Lower rectum to anal canal (above pectinate line), bladder,
vagina (middle third), prostate lymph drainage - correct answer
-internal iliac lymph nodes
9. Tumor grading - correct answer -cellular and histologic features
of the tumor
10. Tumor staging - correct answer -size of primary tumor
11. Degree of involvement of regional lymph nodes, metastases
12. Rheumatoid arthritis effects on: TNF, IL-1, Segmented
Neutrophils, Complement (C3) - correct answer -all increased
except Complement which is used up and decreased
, Page | 3
13. Peptide transporter shuttles antigens into the ER so it can be
complexed with what - correct answer -MHC1
14. Bare Lymphocyte Syndrome Type I - correct answer -TAP
mutation (peptide transporter)
15. Autoimmune Lymphoproliferative Syndrome (ALPS) - correct
answer -mutation in either Fas ligand or Fas receptor
16. Baseline risk of a VSD - correct answer -2-3%
17. Inheritance of AD with one parent heterozygous or X-linked
recessive to sons of carrier mothers- % risk - correct answer -
50%
18. Zenker diverticulum location (2) - correct answer -between
cricopharyngeus and inferior pharyngeal constrictor muscle
