SOLUTIONS
202
What is the result when sedatives and antidepressants inhibit
Methadone"s metabolism? Correct Answer results in large
elevations in blood concentrations, often resulting in unexpected
fatalities
203
How many people are thought to be opioid-dependent people in
the US?
How many of those people are reached through Methadone
maintenance programs? Correct Answer 810,000 opioid-
dependent people in US
170,000 people reached through Methadone maintenance
programs
204
In recent years, what has become a major problem due to
methadone clinic programs and physicians' prescriptions for
analgesic effects? Correct Answer diversion of Methadone
has become a major problem
205
What are the results when the large doses of Methadone
prescribed for an opioid-dependent person are taken by a
nonopioid-dependent person? (2) Correct Answer When large
doses (40 to 100 milligrams) are taken, the results can be :
,1. severe respiratory depression
2. death
206
It has been found you need a lot of what to metabolize a drug?
Correct Answer you need a lot of pharmacologic enzymes
207
Are there other drugs than methadone that are long lasting?
Correct Answer yes
208
What did the results from a 2001 study show dealing with long-
term use of heroin? Correct Answer If people had a severe
addiction to begin with, the addiction would not go away easily
because it is hard to get away from it and recover it.
Long-term heroin abuse results in high rates of physical health,
mental health, and criminal justice problems.
209
Is it estimated that the misuse of opioids is more common or less
common than previously thought? Correct Answer misuse is
more common than previous thought
210
According to a more recent study (2015), what percent of
opioids prescribed for chronic pain are misused? Correct
Answer 21% - 29%
211
,What number ( ___ out of ___) of patients misuse opioids?
Correct Answer 1 out of every 4 or 5 patients misuse opioids
(25%)
This is a high proportion.
212
What number ( ___ out of ___) of patients are addicted to
opioids? Correct Answer 1 out of every 10 or 11 patients are
addicted to opioids
(10%)
213
Definition of opioid misuse. Correct Answer using the
medication in ways other than instructed regardless of harmful
effects
214
Definition of opioid addition. Correct Answer continued
opioid use despite potential or actual harmful effects
215
What is the gap between the estimated rates of opioid misuse
and actual addiction? Correct Answer 8% - 12%
216
What do researchers recommend that healthcare providers do
better (considering the gap between rates of opioid misuse and
actual addition)? Correct Answer healthcare providers should
better target their resources to address problematic use
, 217
How can healthcare providers help address problematic use?
Correct Answer 1. patient education
2. monitor patients at risk for misuse
218
What do 35 out of 38 studies suggest about opioid misuse and
the US? Correct Answer suggests that opioid misuse is of
high interest in the US and it is perhaps a problem that is
somehow uniquely relevant to the US
219
What do antagonists do? Correct Answer will either block or
reduce the effects of agonists or mixed-agonists
220
Antagonists
Each is a structural derivative of what? Correct Answer
oxymorphone, a pure opioid agonist
221
Antagonists
What drug is a Narcan prototype? Correct Answer Naloxone
222
Antagonists