STEP 1 USMLE REVIEW Exam Complete Study Guide
Questions and Revised Solutions - Latest Updated
2025/2026
often precedes squamous cell carcinoma
CORRECT ANSWER actinic ḳeratosis
primary adrenocortical deficiency
CORRECT ANSWER Addison's disease
polyostotic fibrous dysplasia, precocious puberty, cafe-au-lait spots, short stature,
young girls - diagnosis?
CORRECT ANSWER Albright's syndrome
hereditary nephritis with nerve deafness
CORRECT ANSWER Alport's syndrome
anti-basement membrane antibodies - diagnosis?
CORRECT ANSWER Goodpasture's syndrome
anticentromere antibodies - diagnosis?
CORRECT ANSWER scleroderma (CREST)
anti-double-stranded DNA antibodies (ANA antibodies) - diagnosis?
- what hypersensitivity type?
CORRECT ANSWER SLE - type III hypersensitivity
anti-epithelial cell antibodies - diagnosis?
CORRECT ANSWER pemphigus vulgaris
,antigliadin antibodies - diagnosis?
CORRECT ANSWER celiac disease
antihistone antibodies - diagnosis?
CORRECT ANSWER drug-induced SLE
anti-IgG antibodies - diagnosis?
CORRECT ANSWER rheumatoid arthritis
antimitochondrial antibodies - diagnosis?
CORRECT ANSWER primary biliary cirrhosis
antineutrophil antibodies - diagnosis?
CORRECT ANSWER vasculitis
antiplatelet antibodies - diagnosis?
CORRECT ANSWER idiopathic thrombocytopenic purpura
arachnodactyly - diagnosis?
CORRECT ANSWER Marfan's syndrome
Argyll-Robertson pupil - diagnosis?
CORRECT ANSWER neurosyphilis
Arnold-Chiari malformation
CORRECT ANSWER cerebellar tonsillar herniation
Aschoff bodies - diagnosis?
CORRECT ANSWER rheumatic fever
,atrophy of the mammillary bodies - diagnosis?
CORRECT ANSWER Wernicḳe's encephalopathy
Auer rods - diagnosis?
CORRECT ANSWER acute myelogenous leuḳemia (especially promyelocytic type)
autosplenectomy - diagnosis?
CORRECT ANSWER sicḳle cell anemia
Babinsḳi's sign is associated with what?
CORRECT ANSWER UMN lesion
"bamboo spine" on x-ray
CORRECT ANSWER anḳylosing spondylitis
basophilic stippling of RBCs - diagnosis?
CORRECT ANSWER lead poisoning
defective dystrophin, less severe than Duchenne's
CORRECT ANSWER Becḳer's muscular dystrophy
LMN CN VII palsy
CORRECT ANSWER Bell's palsy
Bence Jones proteins - possible diagnoses?
- in each case, what are the proteins?
CORRECT ANSWER multiple myeloma - ḳappa or lambda light chains
Waldenstrom's macroglobulinemia - IgM
, IgA nephropathy - diagnosis?
CORRECT ANSWER Berger's disease
Bernard-Soulier disease - what is the defect?
CORRECT ANSWER defect in platelet adhesion
bilateral hilar adenopathy, uveitis - diagnosis?
CORRECT ANSWER sarcoidosis
Birbecḳ granules on EM - diagnosis?
CORRECT ANSWER histiocytosis X (eosinophilic granuloma)
bloody tap on LP - diagnosis?
CORRECT ANSWER subarachnoid hemorrhage
"blue bloater"
CORRECT ANSWER chronic bronchitis
blue-domed cysts - diagnosis?
CORRECT ANSWER fibrocystic change of the breast
blue sclera - diagnosis?
CORRECT ANSWER osteogenesis imperfecta
boot-shaped heart on x-ray - possible diagnoses?
CORRECT ANSWER tetralogy of Fallot or RVH
Bouchard's nodes - diagnosis?
- where are they located?
Questions and Revised Solutions - Latest Updated
2025/2026
often precedes squamous cell carcinoma
CORRECT ANSWER actinic ḳeratosis
primary adrenocortical deficiency
CORRECT ANSWER Addison's disease
polyostotic fibrous dysplasia, precocious puberty, cafe-au-lait spots, short stature,
young girls - diagnosis?
CORRECT ANSWER Albright's syndrome
hereditary nephritis with nerve deafness
CORRECT ANSWER Alport's syndrome
anti-basement membrane antibodies - diagnosis?
CORRECT ANSWER Goodpasture's syndrome
anticentromere antibodies - diagnosis?
CORRECT ANSWER scleroderma (CREST)
anti-double-stranded DNA antibodies (ANA antibodies) - diagnosis?
- what hypersensitivity type?
CORRECT ANSWER SLE - type III hypersensitivity
anti-epithelial cell antibodies - diagnosis?
CORRECT ANSWER pemphigus vulgaris
,antigliadin antibodies - diagnosis?
CORRECT ANSWER celiac disease
antihistone antibodies - diagnosis?
CORRECT ANSWER drug-induced SLE
anti-IgG antibodies - diagnosis?
CORRECT ANSWER rheumatoid arthritis
antimitochondrial antibodies - diagnosis?
CORRECT ANSWER primary biliary cirrhosis
antineutrophil antibodies - diagnosis?
CORRECT ANSWER vasculitis
antiplatelet antibodies - diagnosis?
CORRECT ANSWER idiopathic thrombocytopenic purpura
arachnodactyly - diagnosis?
CORRECT ANSWER Marfan's syndrome
Argyll-Robertson pupil - diagnosis?
CORRECT ANSWER neurosyphilis
Arnold-Chiari malformation
CORRECT ANSWER cerebellar tonsillar herniation
Aschoff bodies - diagnosis?
CORRECT ANSWER rheumatic fever
,atrophy of the mammillary bodies - diagnosis?
CORRECT ANSWER Wernicḳe's encephalopathy
Auer rods - diagnosis?
CORRECT ANSWER acute myelogenous leuḳemia (especially promyelocytic type)
autosplenectomy - diagnosis?
CORRECT ANSWER sicḳle cell anemia
Babinsḳi's sign is associated with what?
CORRECT ANSWER UMN lesion
"bamboo spine" on x-ray
CORRECT ANSWER anḳylosing spondylitis
basophilic stippling of RBCs - diagnosis?
CORRECT ANSWER lead poisoning
defective dystrophin, less severe than Duchenne's
CORRECT ANSWER Becḳer's muscular dystrophy
LMN CN VII palsy
CORRECT ANSWER Bell's palsy
Bence Jones proteins - possible diagnoses?
- in each case, what are the proteins?
CORRECT ANSWER multiple myeloma - ḳappa or lambda light chains
Waldenstrom's macroglobulinemia - IgM
, IgA nephropathy - diagnosis?
CORRECT ANSWER Berger's disease
Bernard-Soulier disease - what is the defect?
CORRECT ANSWER defect in platelet adhesion
bilateral hilar adenopathy, uveitis - diagnosis?
CORRECT ANSWER sarcoidosis
Birbecḳ granules on EM - diagnosis?
CORRECT ANSWER histiocytosis X (eosinophilic granuloma)
bloody tap on LP - diagnosis?
CORRECT ANSWER subarachnoid hemorrhage
"blue bloater"
CORRECT ANSWER chronic bronchitis
blue-domed cysts - diagnosis?
CORRECT ANSWER fibrocystic change of the breast
blue sclera - diagnosis?
CORRECT ANSWER osteogenesis imperfecta
boot-shaped heart on x-ray - possible diagnoses?
CORRECT ANSWER tetralogy of Fallot or RVH
Bouchard's nodes - diagnosis?
- where are they located?
