What are the physiologic changes of a geriatric compensatory response to physiologic changes
patient? - ANSWER -reduction in total body is decreased
water and lean body mass
increase in body fat
reduction in kidney and liver mass and function Polypharmacy - ANSWER -use if more
reduction in process that maintains equilibrium medications than is medically necessary
What affects absorption in a geriatric patient? - What are the risk factors of polypharmacy? -
ANSWER -GI changes ANSWER -female, advanced age, multiple
decrease in bowel surface area health care providers, use of OTC to herbals,
slowed gastric emptying multiple chronic diseases
decrease gastric blood flow
decrease swallowing ability
decreased nutrition Pharmacotherapy - ANSWER -the
application of drugs for the purpose of disease
prevention and treatment of suffering
What affects distribution in geriatric patients? -
ANSWER -decrease in muscle mass an
increase in fat in patients so LIPID SOLUBLE What is the Beers criteria? - ANSWER -lists
DRUGS HAVE INCREASED DISTRIBUTION potentially inappropriate drugs that lead to
AND DECREASED ELIMINATION adverse effects in the elderly
decrease in albumin so increase in free drugs -renal dosing of drugs
increase in therapeutic effects as well as drug -drug-drug interactions
toxicity -provides safety info
What affects metabolism in geriatric patients? - What are the 5 adverse drug events? -
ANSWER -decreased hepatic blood flow ANSWER -adverse drug reactions
deceased first pass metabolism medication errors
increased half life therapeutic failures
adverse drug withdrawal events
overdoses
What affects excretion in geriatric patients? -
ANSWER -decreased renal excretion
resulting in prolonged half life and elevated drug adherence - ANSWER -ability of a patient to
levels adhere/comply to a medication regimen
What affects the pharmacodynamics in geriatric What can cause medical nonadherence? -
patients? - ANSWER -age related changes ANSWER -patient not understanding the
in CNS and cardiovascular system (drugs can drug regimen
more easily pass the BBB) cognitive/physical/financial difficulties
changes in the number of drug receptors nonadherence can cause under or over dosing
changes in the sensitivity of receptors to drugs
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