PSYCHOPHARMACOLOGY MIDTERM EXAM 2
NEWEST 2025 COMPLETE QUESTIONS AND
CORRECT DETAILED ANSWERS (VERIFIED
ANSWERS) |ALREADY GRADED A+||BRAND NEW
VERSION!!
Five Common side effects of SSRIs include - CORRECT ANSWER- Anxiety, insomnia, GI distress,
sexual dysfunction (ED), SIADH
Severe side effect of SSRIs in children/adolescents under age 25 years old - CORRECT ANSWER-
suicidal ideation
Life threatening adverse effect of SSRIs, especially when used in combination with other
serotonergic drugs (SNRIs, TCAs, MAOIs, etc.) - CORRECT ANSWER- Serotonin Syndrome
Excess accumulation of serotonin resulting in overstimulation of the nervous system - CORRECT
ANSWER- Serotonin Syndrome
Seven symptoms of Serotonin Syndrome - CORRECT ANSWER- Flushing, hyperthermia, agitation,
muscle rigidity, seizure, coma, HYPERreflexia
,The treatment for serotonin syndrome - CORRECT ANSWER- Cyproheptadine (5-HT2 receptor
antagonist)
Cyproheptadine treats serotonin syndrome by - CORRECT ANSWER- blocking 5-HT2 receptors
(serotonin antagonist)
When SSRIs or SNRIs are stopped abruptly, common symptoms of withdrawal include - CORRECT
ANSWER- Irritability, headaches, and insomnia
Medicine specific side effect of citalopram - CORRECT ANSWER- Prolonged QT interval
(normal=0.4.-0.44 seconds)
This SSRI is pregnancy category D due to associations with congenital heart defects - CORRECT
ANSWER- Paroxetine
All SSRIs but paroxetine (D) are pregnancy category - CORRECT ANSWER- C
Serotonin regulates - CORRECT ANSWER- Mood, emotion, feeding, and reproductive behavior
This class of antidepressants binds to presynaptic SERT and inhibits them from reuptake of
serotonin to increase levels in the synaptic cleft to bind with postsysnaptic 5HT2 receptors -
CORRECT ANSWER- SSRIs
First line therapy for MDD due to milder side effect profiles - CORRECT ANSWER- SSRIs
Six Common SSRIs - CORRECT ANSWER- citalopram, escitalopram, fluoxetine, fluvoxamine,
sertraline, paroxetine
, Onset of therapeutic benefit from SSRIs - CORRECT ANSWER- 4-6 weeks
In addition to MDD, SSRIs also treat - CORRECT ANSWER- Chronic Anxiety, PTSD, OCD, and eating
disorders (bulimia)
Three SSRIs that are inhibitors of Cytochrome P450 enzymes - CORRECT ANSWER- fluoxetine,
fluvoxamine, and paroxetine
Five common SNRIs include - CORRECT ANSWER- duloxetine, venlafaxine, desvenlafaxine,
milnacipran, levomilnacipran
This antidepressant class of medications works by binding to presynaptic SERT and NET to
inhibit them from reuptake of serotonin and norepinephrine to increase their levels in the
synaptic cleft - CORRECT ANSWER- SNRIs
In addition to MDD SNRIs treat - CORRECT ANSWER- Anxiety and neuropathic pain (peripheral
neuropathy)
Medication specific indications of duloxetine: - CORRECT ANSWER- urinary incontinence and
Fibromyalgia
Medication specific indications of venlafaxine: - CORRECT ANSWER- social anxiety, panic
disorders, PTSD, OCD, postmenopausal hot flashes
Six common side effects of SNRIs include: - CORRECT ANSWER- Insomnia, nausea, sexual
dysfunction, hypertension, sweating, headaches
Severe side effect of SNRIs in children/adolescents under age 25 years old: - CORRECT ANSWER-
suicidal ideation