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MLS Hematology Exam Questions with
Detailed Verified Answers
What is the first type of cell produced by the developing embryo? Ans:
Erythrocyte
What percentage of tissue located in the bone marrow cavities of adults is
fat? Ans: 50%
Which of the following is not characteristic of pluripotent hematopoietic
stem cells? Ans: Express the stem marker CD13
In an adult, what are the two best areas for obtaining active bone
marrow by aspiration? Ans: Posterior iliac crest, sternum
What is the normal ratio of myeloid to erythroid precursors in bone
marrow (M:E ratio)? Ans: 4:1
Which of the following does not accurately describe hematopoietic growth
factors? Ans: Action of majority is lineage restricted
In the third month of gestation, what is the primary site of
hematopoiesis? Ans: Liver
The mechanism that relays information about tissue oxygen levels to
erythropoietin-producing sites is located in the: Ans: Kidney
Antigen-independent lymphopoiesis occurs in primary lymphoid tissue
located in the: Ans: Thymus and bone marrow
Programmed cell death is called: Ans: Apoptosis
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In what area of the bone marrow does hematopoiesis take place? Ans:
Cords
Bone marrow cellularity refers to the ration of: Ans: Hematopoietic
tissue to adipose tissue
Interleukins and colony stimulating factors are cytokines produced by:
Ans: Monocytes and T lymphocytes
What is the approximate total blood volume in an adult? Ans: 6 L
The myeloid progenitor cell can produce cells committed to: Ans:
Granulocytic, erythrocytic, monocytic, or megakaryocytic lineages
The largest hematopoietic cells in normal bone marrow are: Ans:
Megakaryocytes
When evaluating a bone marrow aspirate smear, which finding is
considered abnormal? Ans: The presence of 10% myeloblasts on the
cell differential count
As most blood cell lines mature, which of the following is characteristic?
Ans: Nucleus to cytoplasm ratio (N:C) decreases
Which of the following describes thrombopoietin (TPO)? Ans: Hormone
produced by the liver that stimulates megakaryopoiesis
When the hepatic phase of fetal life is reactivated in an adult,
hematopoiesis can be termed: Ans: Myeloid metaplasia or
extramedullary
What is the average life span of a normal red blood cell? Ans: 120 days
The Na+-K+ cation pump is an important mechanism in keeping the red
blood cell intact. Its function is to maintain a high level of: Ans:
Intracellular K+
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Which of the following depicts the structure of the hemoglobin molecule?
Ans: Four heme groups, four globin chains
Which of the following describes the process known as culling? Ans:
Removal of abnormal red cells by spleen
Hemoglobin forms that are incapable of oxygen transport include: Ans:
Carboxyhemoglobin and methemoglobin
The majority of iron found in an adult is a constituent of: Ans:
Hemoglobin
A senescent red blood cell is one that has: Ans: Lived its life span
What red cell morphologic abnormality is described by the term
"poikilocytosis"? Ans: Deviations from normal shape
Howell-Jolly bodies are composed of: Ans: DNA
When spherocytes are reported, what is observed on the peripheral blood
smear? Ans: Red cells without a central pallor
The red cells found in lead poisoning characteristically exhibit coarse
granules composed of __________ that are reported as _________.
Ans: Aggregated ribosomes; basophilic stippling
Rouleaux of red blood cells when seen in the monolayer of a blood smear
is characteristic of: Ans: Multiple myeloma
Which of the following is most frequently associated with the inclusion
bodies seen in Color Plate 1? Ans: Post-splenectomy
Which of the following statements about iron absorption is true? Ans:
Absorption increases when erythropoietic activity increases
What term describes a mature red blood cell that contains iron granules
or deposits? Ans: Siderocyte
MLS Hematology Exam Questions with
Detailed Verified Answers
What is the first type of cell produced by the developing embryo? Ans:
Erythrocyte
What percentage of tissue located in the bone marrow cavities of adults is
fat? Ans: 50%
Which of the following is not characteristic of pluripotent hematopoietic
stem cells? Ans: Express the stem marker CD13
In an adult, what are the two best areas for obtaining active bone
marrow by aspiration? Ans: Posterior iliac crest, sternum
What is the normal ratio of myeloid to erythroid precursors in bone
marrow (M:E ratio)? Ans: 4:1
Which of the following does not accurately describe hematopoietic growth
factors? Ans: Action of majority is lineage restricted
In the third month of gestation, what is the primary site of
hematopoiesis? Ans: Liver
The mechanism that relays information about tissue oxygen levels to
erythropoietin-producing sites is located in the: Ans: Kidney
Antigen-independent lymphopoiesis occurs in primary lymphoid tissue
located in the: Ans: Thymus and bone marrow
Programmed cell death is called: Ans: Apoptosis
, Page | 2
In what area of the bone marrow does hematopoiesis take place? Ans:
Cords
Bone marrow cellularity refers to the ration of: Ans: Hematopoietic
tissue to adipose tissue
Interleukins and colony stimulating factors are cytokines produced by:
Ans: Monocytes and T lymphocytes
What is the approximate total blood volume in an adult? Ans: 6 L
The myeloid progenitor cell can produce cells committed to: Ans:
Granulocytic, erythrocytic, monocytic, or megakaryocytic lineages
The largest hematopoietic cells in normal bone marrow are: Ans:
Megakaryocytes
When evaluating a bone marrow aspirate smear, which finding is
considered abnormal? Ans: The presence of 10% myeloblasts on the
cell differential count
As most blood cell lines mature, which of the following is characteristic?
Ans: Nucleus to cytoplasm ratio (N:C) decreases
Which of the following describes thrombopoietin (TPO)? Ans: Hormone
produced by the liver that stimulates megakaryopoiesis
When the hepatic phase of fetal life is reactivated in an adult,
hematopoiesis can be termed: Ans: Myeloid metaplasia or
extramedullary
What is the average life span of a normal red blood cell? Ans: 120 days
The Na+-K+ cation pump is an important mechanism in keeping the red
blood cell intact. Its function is to maintain a high level of: Ans:
Intracellular K+
, Page | 3
Which of the following depicts the structure of the hemoglobin molecule?
Ans: Four heme groups, four globin chains
Which of the following describes the process known as culling? Ans:
Removal of abnormal red cells by spleen
Hemoglobin forms that are incapable of oxygen transport include: Ans:
Carboxyhemoglobin and methemoglobin
The majority of iron found in an adult is a constituent of: Ans:
Hemoglobin
A senescent red blood cell is one that has: Ans: Lived its life span
What red cell morphologic abnormality is described by the term
"poikilocytosis"? Ans: Deviations from normal shape
Howell-Jolly bodies are composed of: Ans: DNA
When spherocytes are reported, what is observed on the peripheral blood
smear? Ans: Red cells without a central pallor
The red cells found in lead poisoning characteristically exhibit coarse
granules composed of __________ that are reported as _________.
Ans: Aggregated ribosomes; basophilic stippling
Rouleaux of red blood cells when seen in the monolayer of a blood smear
is characteristic of: Ans: Multiple myeloma
Which of the following is most frequently associated with the inclusion
bodies seen in Color Plate 1? Ans: Post-splenectomy
Which of the following statements about iron absorption is true? Ans:
Absorption increases when erythropoietic activity increases
What term describes a mature red blood cell that contains iron granules
or deposits? Ans: Siderocyte
