Pharmacological Classification: Names - CORRECT ANSWER-1. Chemical name
Ex: N-acetyl-para-aminophenol
2. Generic name (non-proprietary): broad name assigned to all drugs
Ex: acetaminophen (not capitalized)
3. Trade name (proprietary/brand)
Ex: Tylenol, Aspirin Free, Datril, Liquiprin, Panadol, Tempra
Differences between brand name and generic equivalent - CORRECT ANSWER-
Dosages equivalent- but not the same
Bioavailability -drug available in body
Negative formulary list
-There is a list of drugs in the hospital that they never substitute one for the other
Pharmacological Classification: Function - CORRECT ANSWER-1. Clinical Indication
-How do we use them?
2. Body System
-Autonomic drugs, cardiac drugs, etc.
3. Chemical/pharmacological
-Barbiturates
Drug Sources: Active - CORRECT ANSWER-Plants: active compound
Alkaloids: salts
-Salt base, easily dissolves
Glycosides
-Sugar base
Oils
-Volatile oil given most often, has fumes with it (peppermint, spearmint, etc)
Gums
Resins
**First thing you see on a drug label is active ingredient
,Drug Sources: Active cont. - CORRECT ANSWER-Animal/humans
-Pigs/Horses (Primarin- pregnant mare urine)
-Humans not so much anymore
Natural
-salts
-minerals
-coal tar (Aspirin)
Synthetic/chemical
Recombinant DNA
Pharmacology - CORRECT ANSWER-The study of action and effects of chemical
substances within a living system
Pharmakon = poisons
Drug: "droog" = dry
FDA:
-Drug: any substance other than food, listed in official publication, capable of altering
body structure or function
-Medicine: drug use in prevention and treatment of disease
Multiple Disciplines within Pharmacology - CORRECT ANSWER-Chemistry
Animal/Human physiology
Genetics
Microbiology
Ecology
Sociology
Psychology
Theology
Nutrition
Physics
Botany
Geology
Drug Constituents: Inactive - CORRECT ANSWER-Fillers
-Sugars
Vehicle
-Alcohol in cough syrup
Flavorings and dyes
-Cherry and raspberry
, Sources of Drug Information - CORRECT ANSWER-Official: United States
Pharmacopeia-Drug Information
USPDI: Vol 1: health care providers, Vol 2: Advice for patients (monthly)
American Hospital Formulary Service; Drug Facts and Comparisons
Non-official: Physicians Desk Reference (PDR), Nursing Drug books
Internet
People: Pharmacist, Poison Control Centers
Drug Standards and Regulation - CORRECT ANSWER-National Controls: prior to 1906
USP - United States Pharmacopoeia (1820) recognized standard for drug purity
NF - National formulary (1888): standards for drug formulation
Current: USP-NF - met high standards
Pure Food and Drug Act - 1906 - CORRECT ANSWER--Protect public from mislabeled
drugs
-Established standards: United States Pharmacopoeia and National Formulary
-Empowered federal government to enforce
Updated: 1938 Food, Drug and Cosmetic Act:
-Drugs must be properly tested
The FDA:
-Food and Drug Administration to monitor and regulate
Label:
-Content, name of drug, substances, warning, manufacture, direction, statement must
not be false of misleading
1952 Durham-Humphrey Amendment - CORRECT ANSWER-Prescriptions vs. non
prescription drugs (OTC drugs)
Dispensing of certain drugs (legend) by pharmacist limited to prescription by licensed
health provider (written/verbal)
Legend drug: hypnotic, narcotics, habit forming drugs
-Keep count of the drug