UT Arlington NURS 5334(NURS5334) Exam 1 Quiz: Answered with Rationales (answers at the end of the file pages) 2025.

NURS 5334 — Advanced Pharmacology: Quiz One Exam (50 Questions) Instructions: Choose the best answer for each question. 1. A patient is prescribed Drug A, which has a half-life of 8 hours. How long will it take to reach steady-state concentration with regular dosing? A. 8 hours B. 16 hours C. 24 hours D. 40 hours N . Which statement best describes a drug with high first-pass metabolism? =) A. ltis well absorbed in the Gl tract B. It is highly bioavailable C. ltis extensively metabolized by the liver before reaching systemic circulation D. Itis not affected by liver enzymes w . Which side effect is most commonly associated with tamsulosin? =) A. Constipation B. Hypotension C. Dry mouth D. Insomnia 4. A male patient taking sildenafil should be warned to avoid which medication due to the risk of severe hypotension? =) A. Acetaminophen B. Amlodipine C. Nitrates D.NSAIDs (&) . Which pharmacokinetic change is most common in elderly patients? =) A. Increased renal clearance B. Increased liver enzyme activity C. Increased body water = = =) D. Decreased renal function » . Which of the following drugs is safest for use in pregnancy? =) A. Warfarin B. Lisinopril C. Acetaminophen D. Isotretinoin l . A patient taking alendronate should be instructed to: =) A. Take the drug with food B. Lie down after taking the pill C. Remain upright for 30 minutes after taking it D. Take it before bedtime (00} . Which drug works by inhibiting osteoclast activity? =) A. Calcium carbonate B. Raloxifene C. Alendronate D. Vitamin D O . Which medication is a prostaglandin analog used in glaucoma? =) A. Timolol B. Latanoprost C. Brimonidine D. Pilocarpine 10. What is a common side effect of latanoprost? A. Eye dryness B. Blurred vision C. Iris pigmentation changes D. Retinal detachment 11. What is the primary mechanism of action of bisphosphonates like alendronate? A. Stimulate osteoblast activity B. Inhibit osteoclast-mediated bone resorption C. Increase calcium absorption in the gut D. Enhance parathyroid hormone activity 12. Which medication is commonly used for urinary tract pain relief and turns urine orange? =) A. Nitrofurantoin B. Trimethoprim C. Phenazopyridine D. Ciprofloxacin 13. Which class of drugs is first-line for treating benign prostatic hyperplasia (BPH)? A. PDE-5 inhibitors B. 5-alpha reductase inhibitors C. Alpha-1 blockers D. Anticholinergics 14. Which of the following is a key consideration when prescribing drugs to neonates? =) A. They have increased renal clearance B. Their liver enzymes are fully mature C. They have immature blood-brain barriers D. They metabolize drugs rapidly 15. Which of the following medications is most appropriate for treating glaucoma? =) A. Acetazolamide B. Latanoprost C. Diphenhydramine D. Atropine 16. Which drug is most likely to cause ototoxicity? =) A. Amoxicillin B. Furosemide C. Lisinopril D. Metformin 17. Why are elderly patients at higher risk for adverse drug reactions? A. Increased muscle mass B. Increased renal clearance C. Polypharmacy D. Faster hepatic metabolism 18. Which class of drugs is contraindicated in pregnancy due to risk of fetal renal damage? =) A. Beta blockers B. ACE inhibitors C. Antacids D. Antihistamines 19. What is the most appropriate action when prescribing a narrow therapeutic index drug? A. Use a higher loading dose B. Avoid blood level monitoring C. Monitor drug levels regularly D. Prescribe PRN 20. A drug with a high volume of distribution (Vd) is likely to: A. Stay in the plasma B. Be widely distributed in tissues C. Be quickly eliminated D. Be confined to the CNS 21. Which eye medication can cause systemic beta-blocker effects if not administered properly? A. Latanoprost B. Timolol C. Pilocarpine D. Brimonidine 22. When prescribing to a breastfeeding mother, the safest choice is typically a drug that is: A. Lipophilic with high protein binding B. Hydrophilic with low oral bioavailability C. Metabolized by CYP450 enzymes D. Rapidly excreted by the kidneys 23. What is the primary concern when prescribing aminoglycosides to elderly patients? A. Hepatotoxicity B. Ototoxicity C. Cardiotoxicity D. Teratogenicity 24. What is a major risk of prescribing topical corticosteroids long-term? A. Increased pigmentation B. Skin atrophy C. Systemic acne D. Hypertension 25. Which class of antibiotics is associated with tendon rupture as a serious side effect? A. Macrolides B. Fluoroquinolones C. Cephalosporins D. Sulfonamides 26. Which factor can reduce drug absorption in elderly patients? A. Increased gastric acid B. Delayed gastric emptying C. Increased hepatic blood flow D. Increased intestinal motility 27. Which is a Schedule Il controlled substance? A. Acetaminophen with codeine B. Alprazolam C. Morphine D. Diphenhydramine 28. Which of the following drugs is considered safe to use during lactation? A. Tetracycline B. Lithium C. Ibuprofen D. Amiodarone 29. What is the therapeutic goal when prescribing a selective alpha-1 antagonist like tamsulosin for BPH? A. Increase testosterone production B. Relax prostatic smooth muscle C. Shrink prostate tissue D. Inhibit androgen receptor activity 30. Which vitamin enhances calcium absorption in the gut? A.Vitamin C B. Vitamin D C. Vitamin B12 D. Vitamin K 31. In pediatric patients, drug dosing is typically calculated based on: =) A. |deal body weight B. Body surface area or weight (kg) C. Ageinyears D. Fixed dose regimens 32. Which of the following drugs is contraindicated in glaucoma? A. Pilocarpine B. Latanoprost C. Atropine D. Timolol 33. Which medication class should be avoided in elderly patients with a history of falls? A. SSRIs B. Anticholinergics C. ACE inhibitors D. Statins 34. Why is it important to instruct patients not to abruptly stop beta-blockers? A. It causes excessive urination B. It can lead to rebound hypertension or angina C. It causes muscle weakness D. It can lead to liver toxicity 35. Which CYP450 enzyme is primarily responsible for metabolizing many drugs? A.CYP1A2 B.CYP2C19 C.CYP3A4 D. CYP2E1 36. Which parameter best reflects the extent of drug distribution into body tissues? A. Clearance B. Half-life C. Volume of distribution D. Bioavailability 37. Which of the following is a common adverse effect of bisphosphonates? A. Constipation B. Esophagitis C. Hypercalcemia D. Hypertension 38. Which drug class is indicated for the treatment of overactive bladder? A. Beta-blockers B. Anticholinergics C. Alpha-blockers D. Diuretics 39. Which population is most at risk for drug toxicity due to decreased renal clearance? A. Neonates B. Adults with normal renal function C. Elderly D. Adolescents 40. Which drug is used for otitis externa and covers Pseudomonas? =) A. Amoxicillin B. Ciprofloxacin C. Erythromycin D. Clindamycin