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1) type 1 DM - usually have an absolute insulin
defiency. Caused by autoimmune or unknown. Prone
to ketoacidosis.
2) type 2 DM- individuals who are insulin resistant and
usually relative insulin deficiency. Etiology is unknown.
Classic signs polyuria, polydipsia, and polyphagia.
Differentiate the types of Many people with type 2 are obese or have an
diabetes mellitus and their increase of fat in the abdominal area. other risk factors
respective risk factors in aging, sedentary lifestyle, hypertension, and prior
pregnancy. gestational diabetes.
3) Pregestational diabetes - is the label sometimes
given to type 1 or 2 diabetes that existed before
pregnancy.
4) GDM - is any degree of glucose intolerance with its
onset or first recognition during pregnancy.
, A) first trimester - Insulin need is reduced because of
increased insulin production by the pancreas and
increased peripheral sensitivity; nausea, vomiting, and
decreased food intake by mother and glucose
transfer to embryo/fetus contributes to hypoglycemia.
B) Second trimester: Insulin need increases as
placental hormones, cortisol, and insulinase act as
insulin antagonists, decreasing the effectiveness of
insulin.
Compare insulin
requirements during
C)Third trimester: insulin requirements gradually
pregnancy, the
increase increase until about 36 wks of gestation.
postpartum period, and
lactation.
D) Day of delivery: maternal insulin requirement drop
drastically to approach prepregnancy levels.
E) Breastfeeding mother maintains lower insulin
requirements, as much as 25% less than prepregnancy;
insulin need of nonbreastfeeding mother returns to
prepregnancy levels in 7 to 10 days.
F) at weaning of breastfeeding infant, mother's insulin
need returns to prepregnancy levels.
, A) Maternal risks/complications: GDM with an A1c > 6
there is a 28% increase in early pregnancy loss.
Cesarean birth - failure to progress or failure of
descent. Preterm birth & labor. Ketoacidosis in 2nd &
3rd trimesters. Hypoglycemia occurs during sleep
early in pregnancy when hepatic production of
glucose is dimished and peripheral use of glucose is
enhanced. Hyadramnios - 10x more likely.
Identify maternal and fetal
Hypertensive disorders - preeclampsia, eclampsia.
risks or complications
UTI. severe diabetes.
associated with diabetes
in pregnancy.
B) Fetal risks/complications - Stillbirth. Congenital
anomalies 6% - 10% increase. CNS defects -
anencephaly, open spina bifida. Cardiac defects -
Ventricular septal defects (VSD) & transposition of the
great vessels. Caudal regression - 200 to 400x due to
diabetic mothers. Macrosomia. Hypoglycemia.
Respiratory distress syndrome. Polycythemia.
Hyperbilirubinemia.
Develop a plan of care for ...
the pregnant woman with
pregestational or
gestational diabetes.