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Chapter 07: Methods of Calculation for Individualized Drug Dosing
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Kee: Clinical Calculations: With Applications to General and Specialty Areas, 10th Editio
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OTHER

BodySSurfaceSAreaSbySSquareSRoot

1. Order:ScyclophosphamideS500Smg/m2SinS500SmLSofSnormalSsalineSsolutionS(NSS)SoverS90S
minutes
PatientSheightSandSweight:S5SftS10Sin,S142Slb
DrugSavailable:ScyclophosphamideS100SmgSdiluteSwithS5SmLSofSsterileSwater;SyieldsS20Smg/mL
a. WhatSisStheSpatient’sSbodySsurfaceSareaS(BSA)S(m2)?
b. WhatSisStheStotalSdose?
c. HowSmanySmillilitersSshouldSyouSprepare?

ANS:

a.
b. 500Smg/m2SS1.78Sm2S=S890Smg
c. FE:S890Smg/100SmgSS5SmLS=S44.5SmL

OR




2. Order:ScisplatinS50Smg/m2SinS500SmLSofSNSSSintravenouslySoverS90SminutesS
PatientSheightSandSweight:S5SftS6Sin,S160Slb
DrugSavailable:ScisplatinS100Smg/100SmL
a. WhatSisStheSpatient’sSBSAS(m2)?
b. WhatSisStheStotalSdose?
c. HowSmanySmillilitersSshouldSyouSprepare?

ANS:

a.
b. 50SmgSS1.84Sm2S=S92Smg
c. FE:S92Smg/100SmgSS100SmLS=S92SmL

OR




3. ForStheSfollowingSquestions,SuseStheSsquareSrootSmethodSand/orSnomogram.SNoteSdiscrepanciesS
betweenSmethods.




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GiveSdacarbazineS250Smg/m2/daySS5Sdays.SP
atientSheight:S5SftS10Sin
PatientSweight:S173SlbSWha
tSisStheSdailySdoseSwith
a. squareSrootSmethod?
b. nomogram?

ANS:

a.
250Smg/m2/daySS1.97Sm2S=S493Smg/day
b. HeightS70Sin,SweightS173Slb,SintersectsS2.02Sm2S
250Smg/m2/daySS2.02Sm2S=S505SS500Smg/day

4. ForStheSfollowingSquestions,SuseStheSsquareSrootSmethodSand/orSnomogram.SNoteSdiscrepanciesS
betweenSmethods.




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GiveS5-
fluorouracilS450Smg/m2/wk.SPatientS
height:S5SftS6Sin
PatientSweight:S210Slb
WhatSisStheSweeklySdoseSwith
a. squareSrootSmethod?
b. nomogram?

ANS:

a.
450Smg/m2/wkSS2.10Sm2S=S945Smg/wk
b. HeightS66Sin,SweightS210Slb,SintersectsS2.04Sm2S
450Smg/m2/wkSS2.04Sm2S=S918SS920Smg/wk

5. ForStheSfollowingSquestions,SuseStheSsquareSrootSmethodSand/orSnomogram.SNoteSdiscrepanciesS
betweenSmethods.




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