lOMoARcPSD|26582732
2025 ons chemotherapy & immunotherapy
Certification – updated questions and correct
answers included
3 major phases of cell division: - correct answer ✅✅✅interphase mitotic phase
Cytokinesis
3 Steps of interphase: - correct answer ✅✅✅first growth phase (g1)
Synthesis phase (s phase) second
growth phase (g2)
4 Phases of mitosis: - correct answer ✅✅✅prophase
Metaphase
Anaphase
Telophase
Innate immunity: - correct answer ✅✅✅non-specific response, either:
1. Barrier (skin, mucous membranes, flora of skin/gut)
2. Cellular components (phagocytes, natural killer cells, granulocytes, macrophages)
Adaptive immunity: - correct answer ✅✅✅follows innate immunity if unsuccessful.
Memory immunity, including:
1. Humoral immunity (production of antibodies or immunoglobulins)
2. Cell mediated immunity (dependent upon t cells)
3. Regulatory t -cells (prevent autoimmune reactions and limit inflammatory
responses)
Define mutations - correct answer ✅✅✅variations in the nucleotide sequence of a
gene
3 main goals of treatment: - correct answer ✅✅✅cure
Control
Palliation
Define neoadjuvant therapy - correct answer ✅✅✅treatment is given prior to
surgery to shrink the tumor
Define adjuvant therapy - correct answer ✅✅✅additional cancer
Treatment given after the primary treatment to lower the risk that the cancer reoccur
define conditioning/preparative therapy - correct answer ✅✅✅treatments used to
prepare a patient for stem cell transplantation
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2 Types of conditioning therapies: - correct answer ✅✅✅myeloablative
Nonmyeloablative
Define dose density - correct answer ✅✅✅drug dose per unit of time
Define dose intensity - correct answer ✅✅✅amount of drug delivered over time
How is relative dose intensity (rdi) calculated? - correct answer ✅✅✅by
comparing the dose that the patient actually received to the planned dose of the
standard regimen
How do alkylating agents work? - correct answer ✅✅✅by causing a break in the
dna helix strand, interfering with dna replication and causing cell death
3 Subcategories of alkylating agents: - correct answer ✅✅✅1. Nitrogen mustards
2. Platinum-based agents (do not possess an alkyl group but still termed alkylating
agents as they work similarly)
3. Nitrosoureas
Most common subcategory of alkylating agents: - correct answer
✅✅✅nitrogen mustards
Common alkylating agents: - correct answer ✅✅✅cyclophosphamide (cytoxan)
Ifosfamide (ifex)
Bendamustine (treanda)
Common platinum-based agents: - correct answer ✅✅✅cisplatin
(platinol)
Carboplatin (paraplatin)
What is unique about nitrosoureas agents? - correct answer ✅✅✅able to cross
the blood-brain barrier; can be effective in treating some brain tumors
Common nitrosoureas agents: - correct answer ✅✅✅carmustine (bicnu)
Lomustine (ceenu)
Streptozocin (zanosar)
Hypersensitivity can occur with late doses of: - correct answer
✅✅✅carboplatin
These agents are typically categorized as highly emetogenic: - correct answer
✅✅✅1. Alkylating agents
2. Nitrosoureas
Pre-administration labs for alkylating agents and nitrosoureas: - correct
Answer ✅✅✅bun
Creatinine
Cbc w/ diff
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2025 ons chemotherapy & immunotherapy
Certification – updated questions and correct
answers included
3 major phases of cell division: - correct answer ✅✅✅interphase mitotic phase
Cytokinesis
3 Steps of interphase: - correct answer ✅✅✅first growth phase (g1)
Synthesis phase (s phase) second
growth phase (g2)
4 Phases of mitosis: - correct answer ✅✅✅prophase
Metaphase
Anaphase
Telophase
Innate immunity: - correct answer ✅✅✅non-specific response, either:
1. Barrier (skin, mucous membranes, flora of skin/gut)
2. Cellular components (phagocytes, natural killer cells, granulocytes, macrophages)
Adaptive immunity: - correct answer ✅✅✅follows innate immunity if unsuccessful.
Memory immunity, including:
1. Humoral immunity (production of antibodies or immunoglobulins)
2. Cell mediated immunity (dependent upon t cells)
3. Regulatory t -cells (prevent autoimmune reactions and limit inflammatory
responses)
Define mutations - correct answer ✅✅✅variations in the nucleotide sequence of a
gene
3 main goals of treatment: - correct answer ✅✅✅cure
Control
Palliation
Define neoadjuvant therapy - correct answer ✅✅✅treatment is given prior to
surgery to shrink the tumor
Define adjuvant therapy - correct answer ✅✅✅additional cancer
Treatment given after the primary treatment to lower the risk that the cancer reoccur
define conditioning/preparative therapy - correct answer ✅✅✅treatments used to
prepare a patient for stem cell transplantation
Downloaded by NELSON KIIRU ()
, lOMoARcPSD|26582732
2 Types of conditioning therapies: - correct answer ✅✅✅myeloablative
Nonmyeloablative
Define dose density - correct answer ✅✅✅drug dose per unit of time
Define dose intensity - correct answer ✅✅✅amount of drug delivered over time
How is relative dose intensity (rdi) calculated? - correct answer ✅✅✅by
comparing the dose that the patient actually received to the planned dose of the
standard regimen
How do alkylating agents work? - correct answer ✅✅✅by causing a break in the
dna helix strand, interfering with dna replication and causing cell death
3 Subcategories of alkylating agents: - correct answer ✅✅✅1. Nitrogen mustards
2. Platinum-based agents (do not possess an alkyl group but still termed alkylating
agents as they work similarly)
3. Nitrosoureas
Most common subcategory of alkylating agents: - correct answer
✅✅✅nitrogen mustards
Common alkylating agents: - correct answer ✅✅✅cyclophosphamide (cytoxan)
Ifosfamide (ifex)
Bendamustine (treanda)
Common platinum-based agents: - correct answer ✅✅✅cisplatin
(platinol)
Carboplatin (paraplatin)
What is unique about nitrosoureas agents? - correct answer ✅✅✅able to cross
the blood-brain barrier; can be effective in treating some brain tumors
Common nitrosoureas agents: - correct answer ✅✅✅carmustine (bicnu)
Lomustine (ceenu)
Streptozocin (zanosar)
Hypersensitivity can occur with late doses of: - correct answer
✅✅✅carboplatin
These agents are typically categorized as highly emetogenic: - correct answer
✅✅✅1. Alkylating agents
2. Nitrosoureas
Pre-administration labs for alkylating agents and nitrosoureas: - correct
Answer ✅✅✅bun
Creatinine
Cbc w/ diff
Downloaded by NELSON KIIRU ()
