Antipsychotics NURS 752 Final Exam and All Correct Answers.

Concept of 1st Gen binding thresholds - Answer The degree of D2 receptor binding in the mesolimbic system is close to 80% to have best effects for relieving psychosis. PROBLEM - 1st gen don't discriminate and block D2 receptors everywhere in the brain. When D2 increases over 80% in the dorsal striatum EPS effects occur and, in the pituitary, hyperpotassemia occur. Three main features of neuroleptics include: - Answer Psychomotor slowing, emotional quieting and affective indifference. Positive symptoms include: - Answer Delusions, Hallucinations and Thought Disorder. Negative symptoms include: - Answer •Loss or diminution of normal function •Lack Loss or diminution of normal function •Lack of motivation •Poverty of speech •Blunted affect •Poor self-care •Social withdrawal of motivation Overactivity or Underactivity of the mesocortical dopamine systemmediate the negative, cognitive, and affective symptoms of schizophrenia? - Answer Underactivity Cognitive symptoms include: - Answer •Disordered thinking •Reduced ability to focus attention •Prominent learning and memory difficulties •Subtle changes may appear years before symptoms become florid •Florid changes: Thinking and speech may be completely incomprehensible to others Which drugs reverse effects of Parkinsonism? - Answer •diphenhydramine, trihexyphenidyl, and benztropine. What is the first drug approved for Tardive Dyskinesia? - Answer Valbenazine (Ingrezza)