BIMM 114 Final Exam Part II questions
n answers rated A+
What is unique about the structure of the sub genomic RNAs produced by the coronaviruses? -
correct answer ✔✔ the leader sequence at the 5' end is the same.
Which of the following describes the phenomenon of antibody-dependent enhancement? -
correct answer ✔✔ Antibodies bound to a flavivirus particle lead to entry via the Fc receptor
and increased infection of innate immune cells
The discontinuous transcription model summarizes how coronavirus RDRP jumps and reattaches
to the viral genome. Which coronavirus genes are expressed through this process? - correct
answer ✔✔ genes at the 3' end of the genome
Which of the following viruses do not contain a 5' cap on the 5' end of their viral genome? -
correct answer ✔✔ Poliovirus
In the mature flavivirus virion, the fusion peptide on the E protein is buried in the dimer
interface. Which of the following conditions causes the fusion peptide to become exposed? -
correct answer ✔✔ Drop in pH in the endosome
Which of the following statements comparing flaviviruses with picornaviruses is FALSE? - correct
answer ✔✔ They both have enveloped virions
(all else are true)
- They both encode genes for structural proteins at the 5' end of the genome
- They both produce their proteins from a single open-reading frame
- They both produce viral proteases to cleave the polyprotein
, The complex RNA structure called a pseudoknot in the genome of coronaviruses is involved in
which of the following processes? - correct answer ✔✔ Ribosomal frameshifting from ORF1a to
ORF1b.
Which of the following viruses have particles around 50 nm in diameter? - correct answer ✔✔
Flaviviruses
Which of the following diseases is NOT caused by a member of the picornavirus family? - correct
answer ✔✔ Influenza
Which of the following cellular proteases cleaves the PrM protein releasing the pre peptide
during flavivirus particle maturation - correct answer ✔✔ furin
Which of the following describes the mechanism used by coronaviruses to produce the ORF1b
protein? - correct answer ✔✔ Ribosomal frameshifting
The poliovirus protease cleave the cellular eIF-4G protein. Which of the following cellular
processes does this have an effect on? - correct answer ✔✔ Cap-dependent translation
Coronaviruses are signficant pathogens because they all cause SARS. True or False? - correct
answer ✔✔ False
Picornaviruses have the longest RNA genome of any known virus (T/F) - correct answer ✔✔
False
Flaviviruses mediate proteolysis of all of their proteins from the polypeptide using a viral
protease. True or False? - correct answer ✔✔ False, they use furin proteases as well.
Coronavirus particles are around 120 to 160 nm in diameter in part due to their large genome
size. True or False? - correct answer ✔✔ True
n answers rated A+
What is unique about the structure of the sub genomic RNAs produced by the coronaviruses? -
correct answer ✔✔ the leader sequence at the 5' end is the same.
Which of the following describes the phenomenon of antibody-dependent enhancement? -
correct answer ✔✔ Antibodies bound to a flavivirus particle lead to entry via the Fc receptor
and increased infection of innate immune cells
The discontinuous transcription model summarizes how coronavirus RDRP jumps and reattaches
to the viral genome. Which coronavirus genes are expressed through this process? - correct
answer ✔✔ genes at the 3' end of the genome
Which of the following viruses do not contain a 5' cap on the 5' end of their viral genome? -
correct answer ✔✔ Poliovirus
In the mature flavivirus virion, the fusion peptide on the E protein is buried in the dimer
interface. Which of the following conditions causes the fusion peptide to become exposed? -
correct answer ✔✔ Drop in pH in the endosome
Which of the following statements comparing flaviviruses with picornaviruses is FALSE? - correct
answer ✔✔ They both have enveloped virions
(all else are true)
- They both encode genes for structural proteins at the 5' end of the genome
- They both produce their proteins from a single open-reading frame
- They both produce viral proteases to cleave the polyprotein
, The complex RNA structure called a pseudoknot in the genome of coronaviruses is involved in
which of the following processes? - correct answer ✔✔ Ribosomal frameshifting from ORF1a to
ORF1b.
Which of the following viruses have particles around 50 nm in diameter? - correct answer ✔✔
Flaviviruses
Which of the following diseases is NOT caused by a member of the picornavirus family? - correct
answer ✔✔ Influenza
Which of the following cellular proteases cleaves the PrM protein releasing the pre peptide
during flavivirus particle maturation - correct answer ✔✔ furin
Which of the following describes the mechanism used by coronaviruses to produce the ORF1b
protein? - correct answer ✔✔ Ribosomal frameshifting
The poliovirus protease cleave the cellular eIF-4G protein. Which of the following cellular
processes does this have an effect on? - correct answer ✔✔ Cap-dependent translation
Coronaviruses are signficant pathogens because they all cause SARS. True or False? - correct
answer ✔✔ False
Picornaviruses have the longest RNA genome of any known virus (T/F) - correct answer ✔✔
False
Flaviviruses mediate proteolysis of all of their proteins from the polypeptide using a viral
protease. True or False? - correct answer ✔✔ False, they use furin proteases as well.
Coronavirus particles are around 120 to 160 nm in diameter in part due to their large genome
size. True or False? - correct answer ✔✔ True
