Please check the examination details below before entering your candidate information
Candidate surname Other names
Centre Number Candidate Number
Pearson Edexcel International GCSE
Thursday 8 May 2025
Afternoon (Time: 1 hour 45 minutes) Paper
reference 4HB1/01R
Human Biology
UNIT: 4HB1
PAPER: 01R
You must have: Total Marks
Ruler
Candidates may use a calculator
Instructions
• Use black ink or ball-point pen.
•• IfFillpencil is used for diagrams/sketches/graphs it must be dark (HB or B).
in the boxes at the top of this page with your name,
centre number and candidate number.
• Answer all questions.
• Answer the questions in the spaces provided
– there may be more space than you need.
• Show all the steps in any calculations and state the units.
Information
• The total mark for this paper is 90.
• – usemarks
The for each question are shown in brackets
this as a guide as to how much time to spend on each question.
Advice
• Read each question carefully before you start to answer it.
• Write your answers neatly and in good English.
• Checkanswer
Try to every question.
• your answers if you have time at the end.
Turn over
P74628A
©2025 Pearson Education Ltd.
Y:1/1/1/1/
*P74628A0120*
, Answer ALL questions.
1 (a) The sentences are about the heart.
DO NOT WRITE IN THIS AREA DO NOT WRITE IN THIS AREA DO NOT WRITE IN THIS AREA
Complete the sentences by using words or numbers from the box.
(8)
80 100 120 atria body diastolic elastic tissue
lungs muscle systolic tendon vena cava ventricles
The heart consists of four chambers.
The two upper chambers are called ............................................................... .
The left upper chamber receives blood from the ............................................................... whilst
the right upper chamber receives blood from the body through the
. .. .. .. .. .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
The two lower chambers are called ............................................................... .
The left lower chamber pumps blood to the ............................................................... .
This left lower chamber has a very thick wall made of ............................................................... .
When the chamber contracts, it generates a pressure
known as the . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .................... pressure.
The average value for this pressure is about ............................................................... mmHg.
2
*P74628A0220*
, (b) Cardiac output is the volume of blood pushed out of the heart in one minute.
Cardiac output is calculated using this formula.
DO NOT WRITE IN THIS AREA DO NOT WRITE IN THIS AREA DO NOT WRITE IN THIS AREA
cardiac output = heart rate × stroke volume
The stroke volume is the volume, in dm3, of blood pushed out during one
heartbeat. The heart rate is the number of beats per minute.
Calculate the stroke volume for a person with a heart rate of 68 beats per minute
and a cardiac output of 6.1 dm3.
Give your answer in cm3.
(3)
stroke volume = .................................................... . . . . . . . . . . cm3
(Total for Question 1 = 11 marks)
3
*P74628A0320* Turn over
Candidate surname Other names
Centre Number Candidate Number
Pearson Edexcel International GCSE
Thursday 8 May 2025
Afternoon (Time: 1 hour 45 minutes) Paper
reference 4HB1/01R
Human Biology
UNIT: 4HB1
PAPER: 01R
You must have: Total Marks
Ruler
Candidates may use a calculator
Instructions
• Use black ink or ball-point pen.
•• IfFillpencil is used for diagrams/sketches/graphs it must be dark (HB or B).
in the boxes at the top of this page with your name,
centre number and candidate number.
• Answer all questions.
• Answer the questions in the spaces provided
– there may be more space than you need.
• Show all the steps in any calculations and state the units.
Information
• The total mark for this paper is 90.
• – usemarks
The for each question are shown in brackets
this as a guide as to how much time to spend on each question.
Advice
• Read each question carefully before you start to answer it.
• Write your answers neatly and in good English.
• Checkanswer
Try to every question.
• your answers if you have time at the end.
Turn over
P74628A
©2025 Pearson Education Ltd.
Y:1/1/1/1/
*P74628A0120*
, Answer ALL questions.
1 (a) The sentences are about the heart.
DO NOT WRITE IN THIS AREA DO NOT WRITE IN THIS AREA DO NOT WRITE IN THIS AREA
Complete the sentences by using words or numbers from the box.
(8)
80 100 120 atria body diastolic elastic tissue
lungs muscle systolic tendon vena cava ventricles
The heart consists of four chambers.
The two upper chambers are called ............................................................... .
The left upper chamber receives blood from the ............................................................... whilst
the right upper chamber receives blood from the body through the
. .. .. .. .. .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
The two lower chambers are called ............................................................... .
The left lower chamber pumps blood to the ............................................................... .
This left lower chamber has a very thick wall made of ............................................................... .
When the chamber contracts, it generates a pressure
known as the . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .................... pressure.
The average value for this pressure is about ............................................................... mmHg.
2
*P74628A0220*
, (b) Cardiac output is the volume of blood pushed out of the heart in one minute.
Cardiac output is calculated using this formula.
DO NOT WRITE IN THIS AREA DO NOT WRITE IN THIS AREA DO NOT WRITE IN THIS AREA
cardiac output = heart rate × stroke volume
The stroke volume is the volume, in dm3, of blood pushed out during one
heartbeat. The heart rate is the number of beats per minute.
Calculate the stroke volume for a person with a heart rate of 68 beats per minute
and a cardiac output of 6.1 dm3.
Give your answer in cm3.
(3)
stroke volume = .................................................... . . . . . . . . . . cm3
(Total for Question 1 = 11 marks)
3
*P74628A0320* Turn over
