BIOC 385 Exam 4 questions well
answered already passed
Module 10 - correct answer ✔✔
Structure-function studies of numerous DNA polymerizing enzymes have shown that the
catalytic residues are found within the β sheets of the ________ domain, whereas other regions
form a tunnel through which the DNA passes. - correct answer ✔✔palm
Which of the following descriptions likely explains the finger and thumb domains of a
polymerase in terms of their interaction with DNA?
A. Neither the finger nor the thumb domain interacts with single-stranded DNA.
B. Either the finger or the thumb domain interacts with single-stranded DNA.
C. Both the finger and the thumb domain interact with double-stranded DNA.
D. Both the finger and the thumb domain interact with single-stranded DNA. - correct answer
✔✔B. Either the finger or the thumb domain interacts with single-stranded DNA.
Cytosine in DNA can spontaneously deaminate to produce uracil. Label the figure below
concerning this mechanism.
A. Uracil
B. Cytosine
C. Abasic nucleotide - correct answer ✔✔Left to right: B, A, C
The Holliday junction is a key component of homologous recombination. The Holliday junction is
a region of DNA where __________ (3/2/8/4) different DNA strands come together. Resolution
,of Holliday junctions is completed by _________ (DNA polymerase/reverse
transcriptase/integrase/resolvase) enzymes, which are part of the recombinase complex. -
correct answer ✔✔4; resolvase
Which of the following best relates these three terms: DNA damage, metabolic rate, and
antioxidants?
A. Individuals with a lower metabolic rate who do consume antioxidants have a greater risk of
DNA damage.
B. Individuals with a higher metabolic rate who do not consume antioxidants have a greater risk
of DNA damage.
C. There is no connection between an individual's metabolic rate, consumption of antioxidants,
and DNA damage. - correct answer ✔✔B. Individuals with a higher metabolic rate who do not
consume antioxidants have a greater risk of DNA damage.
The following image shows common chemical modifications of DNA bases. Identify the types of
alkylation caused by reactive oxygen species as observed by dragging the correct names to the
targets.
A. O-alkylation of thymine
B. O-alkylation of cytosine
C. O-alkylation of guanine
D. O-alkylation of adenine - correct answer ✔✔Left (C) right (A)
Ethenoguanine adducts are involved in _________ (normal/abnormal) Watson-Crick base
pairing - correct answer ✔✔Abnormal
What is the nucleotide sequence in the DNA that TBP binds to, which is approximately 30
nucleotides upstream from the transcriptional start site?
, A. TATAAAA
B. Phe301-Phe285-Phe210-Phe193
C. TATA
D. AAAATAT - correct answer ✔✔A. TATAAAA
For a human chromosome that has a central centromere (metacentric), the single (non-
replicated) metacentric chromosome is expected to contain (1/2/3/4) telomeres - correct
answer ✔✔two
What cell is not expected to contain an active telomerase enzyme?
A. embryonic stem cells within the blastula
B. alveolar epithelial cells within deep lung tissue
C. B cells that have undergone a clonal selection
D. primary spermatocytes within a male testis - correct answer ✔✔B. alveolar epithelial cells
within deep lung tissue
Telomerase contains a(n) _________ (RNA/DNA) sequence that binds complementary to and
extends the length of the __________ (nascent/template) strand after DNA replication. - correct
answer ✔✔RNA; template
Resolvase activity will act upon Holliday junctions
and will generate which of the following?
A. only nonrecombinant nucleic acid
B. only recombinant nucleic acid
C. either recombinant or nonrecombinant nucleic acid - correct answer ✔✔C. either
recombinant or nonrecombinant nucleic acid
answered already passed
Module 10 - correct answer ✔✔
Structure-function studies of numerous DNA polymerizing enzymes have shown that the
catalytic residues are found within the β sheets of the ________ domain, whereas other regions
form a tunnel through which the DNA passes. - correct answer ✔✔palm
Which of the following descriptions likely explains the finger and thumb domains of a
polymerase in terms of their interaction with DNA?
A. Neither the finger nor the thumb domain interacts with single-stranded DNA.
B. Either the finger or the thumb domain interacts with single-stranded DNA.
C. Both the finger and the thumb domain interact with double-stranded DNA.
D. Both the finger and the thumb domain interact with single-stranded DNA. - correct answer
✔✔B. Either the finger or the thumb domain interacts with single-stranded DNA.
Cytosine in DNA can spontaneously deaminate to produce uracil. Label the figure below
concerning this mechanism.
A. Uracil
B. Cytosine
C. Abasic nucleotide - correct answer ✔✔Left to right: B, A, C
The Holliday junction is a key component of homologous recombination. The Holliday junction is
a region of DNA where __________ (3/2/8/4) different DNA strands come together. Resolution
,of Holliday junctions is completed by _________ (DNA polymerase/reverse
transcriptase/integrase/resolvase) enzymes, which are part of the recombinase complex. -
correct answer ✔✔4; resolvase
Which of the following best relates these three terms: DNA damage, metabolic rate, and
antioxidants?
A. Individuals with a lower metabolic rate who do consume antioxidants have a greater risk of
DNA damage.
B. Individuals with a higher metabolic rate who do not consume antioxidants have a greater risk
of DNA damage.
C. There is no connection between an individual's metabolic rate, consumption of antioxidants,
and DNA damage. - correct answer ✔✔B. Individuals with a higher metabolic rate who do not
consume antioxidants have a greater risk of DNA damage.
The following image shows common chemical modifications of DNA bases. Identify the types of
alkylation caused by reactive oxygen species as observed by dragging the correct names to the
targets.
A. O-alkylation of thymine
B. O-alkylation of cytosine
C. O-alkylation of guanine
D. O-alkylation of adenine - correct answer ✔✔Left (C) right (A)
Ethenoguanine adducts are involved in _________ (normal/abnormal) Watson-Crick base
pairing - correct answer ✔✔Abnormal
What is the nucleotide sequence in the DNA that TBP binds to, which is approximately 30
nucleotides upstream from the transcriptional start site?
, A. TATAAAA
B. Phe301-Phe285-Phe210-Phe193
C. TATA
D. AAAATAT - correct answer ✔✔A. TATAAAA
For a human chromosome that has a central centromere (metacentric), the single (non-
replicated) metacentric chromosome is expected to contain (1/2/3/4) telomeres - correct
answer ✔✔two
What cell is not expected to contain an active telomerase enzyme?
A. embryonic stem cells within the blastula
B. alveolar epithelial cells within deep lung tissue
C. B cells that have undergone a clonal selection
D. primary spermatocytes within a male testis - correct answer ✔✔B. alveolar epithelial cells
within deep lung tissue
Telomerase contains a(n) _________ (RNA/DNA) sequence that binds complementary to and
extends the length of the __________ (nascent/template) strand after DNA replication. - correct
answer ✔✔RNA; template
Resolvase activity will act upon Holliday junctions
and will generate which of the following?
A. only nonrecombinant nucleic acid
B. only recombinant nucleic acid
C. either recombinant or nonrecombinant nucleic acid - correct answer ✔✔C. either
recombinant or nonrecombinant nucleic acid
