Exam Questions and CORRECT Answers
classic synaptic neurotransmission - CORRECT ANSWER - Presynaptic to synaptic to
post synaptic
retrograde neurotransmission - CORRECT ANSWER - Neurotransmitter moves to
opposite direction from post synaptic to presynaptic
Used to limit a response
volume transmission - CORRECT ANSWER - Neurotransmitter spills over to other
synapses by diffusion
signal transduction cascade - CORRECT ANSWER - Triggered by chemical
neurotransmitter from presynaptic neuron
-Ligand binds to receptor which is activated to bind to G-protien and series of messengers
ultimate goal of signal transduction cascade - CORRECT ANSWER - ultimate goal is to
turn off or on gene (GENE EXPRESSION) and production of phosphoprotien
ultimate targets of signal transmission - CORRECT ANSWER - to turn on or turn off
genes (Gene Expression) and to produce phosphoprotiens
second messenger - CORRECT ANSWER - change occurs to bind to G-protien -which
changes to bind to enzyme -which changes and forms second messenger
2nd messenger found? - CORRECT ANSWER - Intracellular
G-linked protein - CORRECT ANSWER - Activated by binding to receptor after receptor
has been conformational changed by neurotransmitter.
, G-linked protein's role? - CORRECT ANSWER - Once bound to receptor G-linked
protien changes shape and binds to enzyme which then release second messenger to next enzyme
in signal transduction cascade.
phosphoproteins - CORRECT ANSWER - Involved in transduction
Phosphoprotiens are target along STC - these change how Neurotransmitter is released
phosphoproteins formed - CORRECT ANSWER - Helps to send message to gene
One of the end targets along with the gene
Works on ion conduction
transcription factors? - CORRECT ANSWER - Converting DNA into RNA
transcription factors final target - CORRECT ANSWER - gene expression
neuronal gene expression - CORRECT ANSWER - environmental factors can affect gene
expression - (important things to take away)
Epigenetics - CORRECT ANSWER - can turn gene on or off by modifying cromatin in
cell nucleus
4 epigenetics - CORRECT ANSWER - chromatin
DNA methylation
Histone modifications
Other chromatone remodeling events
G-protein linked receptors - CORRECT ANSWER - G- protein important in NT
Major target for psych drugs