Solutions
carboprost (Hemabate) classification Correct Answer
Prostaglandins, synthetic form of endogenous prostaglandin F2
alpha
carboprost considerations Correct Answer Do not administer
to patients with history of asthma
carboprost indication Correct Answer -Approved for
controlling postpartum bleeding that has not already responded
to oxytocin, administered IM q15-90 minutes
-Approved for inducing pharmacologic abortion between 13-20
weeks gestation
carboprost SE Correct Answer nausea, vomiting, diarrhea,
fever, headache,
*uterine rupture*
eclampsia Correct Answer •occurs if hypertension continues
to worsen during pregnancy. This is associated with seizures and
cerebral edema.
•Treatment with magnesium sulfate and/or delivery depending
on severity of preeclampsia.
Indomethacin (Indocin) Correct Answer •NSAID that reduces
prostaglandin production. Indicated for arthritis, inflammatory
conditions, and pediatric patent ductus arteriosus.
- Used off-label as a tocolytic for preterm labor
, •Use is typically limited to 48 hours and prior to 32 weeks
gestation.
indomethacin fetal effects Correct Answer oligohydramnios
and constriction of the ductus arteriosus.
indomethacin SE Correct Answer nausea and vomiting, reflux
and gastritis.
Mag sulfate for preeclampsia Correct Answer •Magnesium
sulfate acts by decreasing the amount of acetylcholine liberated
from the motor nerve terminals and produces a peripheral
neuromuscular blockade.
•It also increases uterine blood flow.
•Magnesium should be continued for 24 hours postpartum or
until the hypertension and preeclamptic symptoms resolve.
•Nursing considerations and assessments the same as when
administered for preterm labor.
magnesium sulfate classification Correct Answer electrolytes,
off-label tocolytic
magnesium sulfate considerations Correct Answer -
Administered via continuous IV with controlled pump device
until preterm contractions diminish
-Typically a loading dose, then maintenance infusion
-"Therapeutic" serum levels will often produce early signs of
magnesium overdose
-Monitor very closely to ensure that levels remain within
prescribed therapeutic range