MAMMALIAN GENETICS BCH5413 EXAM 4 ACTUAL 2025/2026 QUESTIONS AND 100% CORRECT ANSWERS

MAMMALIAN GENETICS BCH5413 EXAM 4 ACTUAL 2025/2026 QUESTIONS AND 100% CORRECT ANSWERS What is the central dogma of molecular biology? - Answer -DNA can be both replicated and transcribed into mRNA, which can be translated into protein T/F: the addition of bulky aromatic rings and/or exposure to UV light can cause the DNA to "bubble." - Answer -True (this is due to intrastrand crosslinking, in which adjacent nucleotides basepair, causing bubbling) T/F: chemotherapy can cause both single and double-stranded breaks in DNA. - Answer -TrueNeed assistance on Online classes, Exams & Assignments? Reach out for instant help!! Full Course Assistance, Plagiarism-free Essay Writing, Research Paper, Dissertation, Discussion Posts, etc…. Confidential & Secure services. Tutors are available for all subjects! Email now at: Why is it very important that damaged DNA is repaired? - Answer - Damaged DNA can lead to incorrect base pairing, which can lead to mutations (permanent changes in the DNA sequence) What is 8-oxyguanine? - Answer -Guanine with a new -C=O bond in place of the original =C-H2 bond What happens to GC base pairing when guanine is converted to 8- oxyguanine? - Answer -8-oxyguanine flips over, causing it to hydrogen bond with adenine (instead of cytosine) and become a thymine in the next round of DNA replication How many hydrogen bonds does 8-oxyguanine have with its partner nucleotide? - Answer -2 (instead of guanine's normal 3) What is cisplatin? - Answer -An agent used in chemotherapy that has lots of bulky side chains What type of DNA damage can be caused by cisplatin? - Answer -Bulky adducts (DNA "bubbles") caused by the addition of large sidechainsand/or intrastrand crosslinking caused by cisplatin binding to 2 adjacent guanines Why is cisplatin an effective treatment for cancer? - Answer -The addition of cisplatin causes damage to DNA, so introducing it to cancer cells can help damage/kill them What type of mutation occurs wh