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ASCP Exam Simulator Questions 2025/2026 – 300+ Practice Q&As with Explanations | Microbiology, Hematology, Transfusion Medicine, Immunology, Urinalysis, Clinical Chemistry & More

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Escrito en
2025/2026

This ASCP Exam Simulator 2025/2026 is a powerful, high-yield question bank featuring over 300+ multiple-choice questions with detailed answers and explanations, tailored to match the current ASCP Board of Certification (BOC) exam standards. Each question mirrors the difficulty and format of the real exam, offering focused content across essential subject areas such as microbiology, hematology, immunohematology, urinalysis, blood banking, immunology, molecular biology, and clinical chemistry. You’ll find diagnostic case scenarios, image-based questions, instrument troubleshooting, and clinical reasoning exercises throughout the simulator. It includes expert-level questions such as: Interpretation of electrophoresis patterns and bone marrow evaluations Advanced antibody panel analysis and transfusion reaction workups Microbiological ID techniques including growth media, Gram stain morphology, and biochemical testing Detailed calculations of renal function, osmolality, hemoglobin indices, and dilutions Identification of parasites, viruses, and bacteria across different body systems Specialized content like tumor markers, HLA antibodies, and immunoglobulin reactions This simulator is ideal for self-assessment and final exam readiness, particularly for students or professionals who prefer an applied, question-based study method. Each answer includes reasoning, formulas, or clinical notes, offering more than just memorization—it builds critical lab judgment. This resource is best suited for: Medical Laboratory Scientist (MLS) and Medical Laboratory Technician (MLT) students ASCP BOC and ASCPi international candidates Students in Biomedical Science, Clinical Laboratory Science, and Medical Technology programs Professionals preparing for recertification, licensure, or postgraduate exams in laboratory disciplines Whether you’re reviewing during rotations, preparing for boards, or revisiting core lab principles, this simulator ensures thorough, exam-focused practice. Keywords: ASCP exam simulator, ASCP BOC practice questions, laboratory science Q&A, microbiology review, hematology questions, immunohematology, urinalysis, transfusion medicine, clinical chemistry, antibody panels, DAT, RhIg, blood bank, electrophoresis, renal function tests, case-based questions, parasitology, tumor markers, coagulation, laboratory calculations

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ASCP Exam Simulator Questions
2025/2026 Exam All Answers and
Illustrations Given



Which of the following instruments measures changes in vapor pressure? -

🧠ANSWER ✔✔Osmometer


What abnormal red blood cell inclusion is composed of multiple small, dark

blue aggregates of ribosomes (RNA) that are distributed throughout the

RBC? - 🧠ANSWER ✔✔Basophilic stippling


A situation may arise when a pathologist recognizes the presence of a

parasite in an H & E - stained section within the lumen of the appendix, as

seen in the upper Image. Studies of additional fields of view in the slide

may locate the ovary and reveal the morphology of the ova contained

within, as is observed in the lower image. Based on these observations,

select the presumptive identification of this parasite. - 🧠ANSWER

✔✔Enterobius vermicularis

,Components of the second line of defense in the human body are -

🧠ANSWER ✔✔Phagocytic cells; complement


Which of the following is true regarding the Lutheran blood group system? -

🧠ANSWER ✔✔Lu^b is a high frequency antigen


Which of the following is a cause of metabolic alkalosis? - 🧠ANSWER

✔✔Excessive vomiting


Parasites which can be found in urinary sediment include all of the

following EXCEPT: - 🧠ANSWER ✔✔Plasmodium malariae


The production of neutral 17-ketosteroids is a measure of which of the

following? - 🧠ANSWER ✔✔Androgen production


Which component of an electrophoresis system sets the pH? - 🧠ANSWER

✔✔Buffer


Which of the following casts might be found in the urine of a healthy

individual after strenuous exercise? - 🧠ANSWER ✔✔Hyaline casts and

granular casts

,What are the abnormal red blood cells (RBCs) indicated by the arrows that

may be suggestive of an individual possessing the Rh null phenotype? -

🧠ANSWER ✔✔Stomatocytes


Which of the following antibody types is the predominant serum antibody

seen in the secondary immune response - 🧠ANSWER ✔✔IgG


Which of the following antibodies is the MOST common cause of severe

hemolytic disease of the newborn? - 🧠ANSWER ✔✔Anti-D


Small intracellular gram-negative cocci were observed in a centrifuged

spinal fluid sediment as presented in the upper photomicrograph. A clinical

diagnosis of meningitis was suspected. Yellow-gray colonies after 24-hour

incubation had been observed on blood agar. Based on the carbohydrate

utilization tube reactions observed in the lower photograph, what is the

presumptive identification of this isolate. - 🧠ANSWER ✔✔Neisseria

meningitidis

Which of the following conditions is MOST frequently associated with anti-

I? - 🧠ANSWER ✔✔Cold agglutinin disease


The site most frequently used to collect bone marrow samples from adults

is: - 🧠ANSWER ✔✔Posterior iliac crest


3
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, A 56-year-old woman with a history of high blood pressure and

cardiovascular disease is evaluated by her physician due to her recent loss

of appetite. The doctor reviews the following test results:

Plasma creatinine = 2.4 mg/dL

Urine creatinine = 65 mg/dL

Urine volume (24 hrs) = 1400 mL

What is the estimated glomerular filtration rate for this patient? - 🧠ANSWER

✔✔(Urine creatinine / plasma creatinine) x (volume / minute) = glomerular

filtration rate (mL/min)

*in order to solve this problem, the 24 hour urine must be converted into

minutes. 1440 minutes should be used as the denominator in the volume

component.

So...for this patient, the calculation would be:

( 65 mg/dL / 2.4 mg/dL ) X ( 1400 mL / 1440 min ) = (27.083) X (0.972

mL/min) =

= 26.32 mL/min

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