, NURSING PHARMACOLOGY TEST BANK: 200 HIGH-YIELD NCLEX-STYLE
PRACTICE QUESTIONS WITH ANSWERS AND EXPLANATIONS BASED ON
THE “OPEN RN NURSING PHARMACOLOGY” TEXTBOOK
BY CHIPPEWA VALLEY TECHNICAL COLLEGE
Table of Contents :Nursing Pharmacology Test Bank
Unit Topic MCQs
Unit 1 Pharmacokinetics & Pharmacodynamics (ADME, Receptors, Half- 001–
020
life)
Unit 2 Legal and Ethical Aspects of Medication Administration 021–
040
Unit 3 Antimicrobials (Antibiotics, Antivirals, Antifungals) 041–
060
Unit 4 Autonomic Nervous System Medications 061–
080
Unit 5 Respiratory Medications (Asthma, COPD, Inhalers) 081–
100
Unit 6 Cardiovascular Medications (Antihypertensives, Diuretics, etc.) 101–
120
Unit 7 Pain and Anti-inflammatory Medications (NSAIDs, Opioids) 121–
140
Unit 8 Endocrine Medications (Insulin, Thyroid, Corticosteroids) 141–
160
Unit 9 Neurological Medications (Seizures, Parkinson’s, Alzheimer’s) 161–
180
Unit Gastrointestinal Medications (Antacids, Laxatives, Antiemetics) 181–
200
10
1|Page
,Unit 1 (Kinetics & Dynamics)
Topic: Absorption, Distribution, Metabolism, Excretion (ADME) & Pharmacodynamics
1. What is the primary site for drug metabolism in the body?
A. Kidneys
B. Lungs
C. Liver
D. Intestines
Answer: C. Liver
Rationale: The liver is the main organ for drug metabolism, where enzymes such as
CYP450 help transform drugs into less active metabolites for excretion.
2. Which pharmacokinetic phase involves drug movement from the site of
administration into the bloodstream?
A. Metabolism
B. Absorption
C. Excretion
D. Distribution
Answer: B. Absorption
Rationale: Absorption is the first step in pharmacokinetics, where the drug enters
circulation from the administration site.
2|Page
, 3. What factor may decrease absorption of oral medications in older adults?
A. Increased gastric acid
B. Faster gastric emptying
C. Decreased blood flow to GI tract
D. Increased subcutaneous fat
Answer: C. Decreased blood flow to GI tract
Rationale: Age-related changes such as reduced GI blood flow can slow drug absorption in
elderly patients.
4. Which of the following is an advantage of transdermal medication administration?
A. Immediate peak effect
B. Avoidance of the first-pass effect
C. Reduced skin irritation
D. Rapid onset of action
Answer: B. Avoidance of the first-pass effect
Rationale: Transdermal drugs bypass the liver initially, improving bioavailability and
reducing metabolism losses.
5. What effect does albumin level have on drug distribution?
A. No effect
B. Low albumin increases free drug availability
C. High albumin decreases free drug availability
D. Both B and C
Answer: D. Both B and C
3|Page
PRACTICE QUESTIONS WITH ANSWERS AND EXPLANATIONS BASED ON
THE “OPEN RN NURSING PHARMACOLOGY” TEXTBOOK
BY CHIPPEWA VALLEY TECHNICAL COLLEGE
Table of Contents :Nursing Pharmacology Test Bank
Unit Topic MCQs
Unit 1 Pharmacokinetics & Pharmacodynamics (ADME, Receptors, Half- 001–
020
life)
Unit 2 Legal and Ethical Aspects of Medication Administration 021–
040
Unit 3 Antimicrobials (Antibiotics, Antivirals, Antifungals) 041–
060
Unit 4 Autonomic Nervous System Medications 061–
080
Unit 5 Respiratory Medications (Asthma, COPD, Inhalers) 081–
100
Unit 6 Cardiovascular Medications (Antihypertensives, Diuretics, etc.) 101–
120
Unit 7 Pain and Anti-inflammatory Medications (NSAIDs, Opioids) 121–
140
Unit 8 Endocrine Medications (Insulin, Thyroid, Corticosteroids) 141–
160
Unit 9 Neurological Medications (Seizures, Parkinson’s, Alzheimer’s) 161–
180
Unit Gastrointestinal Medications (Antacids, Laxatives, Antiemetics) 181–
200
10
1|Page
,Unit 1 (Kinetics & Dynamics)
Topic: Absorption, Distribution, Metabolism, Excretion (ADME) & Pharmacodynamics
1. What is the primary site for drug metabolism in the body?
A. Kidneys
B. Lungs
C. Liver
D. Intestines
Answer: C. Liver
Rationale: The liver is the main organ for drug metabolism, where enzymes such as
CYP450 help transform drugs into less active metabolites for excretion.
2. Which pharmacokinetic phase involves drug movement from the site of
administration into the bloodstream?
A. Metabolism
B. Absorption
C. Excretion
D. Distribution
Answer: B. Absorption
Rationale: Absorption is the first step in pharmacokinetics, where the drug enters
circulation from the administration site.
2|Page
, 3. What factor may decrease absorption of oral medications in older adults?
A. Increased gastric acid
B. Faster gastric emptying
C. Decreased blood flow to GI tract
D. Increased subcutaneous fat
Answer: C. Decreased blood flow to GI tract
Rationale: Age-related changes such as reduced GI blood flow can slow drug absorption in
elderly patients.
4. Which of the following is an advantage of transdermal medication administration?
A. Immediate peak effect
B. Avoidance of the first-pass effect
C. Reduced skin irritation
D. Rapid onset of action
Answer: B. Avoidance of the first-pass effect
Rationale: Transdermal drugs bypass the liver initially, improving bioavailability and
reducing metabolism losses.
5. What effect does albumin level have on drug distribution?
A. No effect
B. Low albumin increases free drug availability
C. High albumin decreases free drug availability
D. Both B and C
Answer: D. Both B and C
3|Page
