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The family of a 68-year-old man who is in the end stages of small cell lung cancer is distraught
at his visible body wasting that has worsened in recent weeks. Which of the following
phenomena best accounts for the patient's anorexia and cachexia? correct answers Products of
the tumor itself as well as a hypermetabolic state cause cachexia
A child possesses a trait that is the result of the interaction of two different genes, neither of
which could have produced the trait independently. Which of the following explanations best
captures the genetic explanation for this? correct answers The outcome is the result of the
interaction between collaborative genes.
A 45-year-old patient who experienced exposure to radiation during an industrial accident
several years prior is being assessed. Which of the following phenomena may underlie the
genetic changes that have been noted in the patient? correct answers Base pairs may have been
rearranged by the radiation exposure.
Which of the following pregnant women has most likely encountered the greatest increase in the
risk that her child will have a fetal anomaly? correct answers A woman who has herpes simplex
and recently recovered from endocarditis
The nurse practitioner is providing care for a patient with a diagnosis of cirrhosis, and he notes
that the patient's sclerae are jaundiced. The nurse practitioner recalls that jaundice is caused by
excess accumulation of bilirubin, a pigment that can accumulate in which part of the cell? correct
answers Cytoplasm
A patient who has a diagnosis of lung cancer is scheduled to begin radiation treatment. The NP
providing pretreatment education is explaining some of the potential unwanted effects of the
treatment. Which of the following statements by the nurse is most accurate? correct answers
"Some patients experience longer-term irritation of skin adjacent to the treatment site."
,A male patient of a nurse practitioner has an autosomal dominant disorder. The patient and his
partner are considering starting a family. Which of the patient's following statements indicates
the patient has an adequate understanding of the genetic basis of this health problem? correct
answers "I know that a single mutant allele is to blame for the health problem."
A group of researchers has identified that the prevalence of two particular genetic disorders share
a statistical correlation. Which of the following statements best conveys the genetic rationale for
this situation? correct answers The genes causing each disorder are likely in the same section of
the same chromosome.
The NP is working with a family whose daughter has been recently diagnosed with the
chromosomal disorder Turner syndrome. The NP would recognize that which of the following
statements about the characteristics of human chromosomes is accurate? correct answers
Autosomes contain the determination of an individual's sex.
The NP is teaching a group of older adults about the value of including foods containing
antioxidants in their diet. Which of the following statements best captures the rationale
underlying the NPs advice? correct answers Antioxidants inhibit the actions of reactive oxygen
species (ROS).
Which target of both chemotherapy and radiation treatment accounts for adverse as well as
therapeutic effects? correct answers Rapidly proliferating cells
Which of the following patients of a primary care nurse practitioner would not require extra
screening for cancer? correct answers A 38-year-old female with Down syndrome and congenital
scoliosis
A 7-year-old boy is admitted to the hospital with a suspected diagnosis of lead toxicity. Which of
the following assessment findings is most congruent with the patient's diagnosis? hi correct
answers Hemoglobin 9.9 g/dL
,The NP is providing care for a 21-year-old female patient with gas gangrene of a compound
fracture in her arm. Which of the following assessment findings would the nurse most reasonably
expect to find when caring for a patient with a diagnosis of gas gangrene? correct answers
Spreading edema
A community health nurse practitioner is teaching a group of female high school students about
the importance of regular Papanicolaou (Pap) smears. The nurse recognizes that which of the
following items underlies the rationale for this teaching? correct answers Cancer of the uterine
cervix develops incrementally at a cellular level.
Which of the following statements most accurately conveys an aspect of cell injury due to
impaired calcium homeostasis? correct answers Injured cells tend to accumulate calcium.
A woman is surprised to read on the Internet that certain infections can cause cancer and has
sought clarification from her nurse practitioner during an office visit. How can the NP best
respond to the woman's query? correct answers "There are many viruses, but only a very few of
them have been shown to cause cancer in humans."
The nurse practitioner working in occupational health has been asked to speak to a group of
factory workers about the importance of wearing gloves when working with strong chemicals
such as turpentine and paint thinner. Which of the following characteristics of cell membranes
underlies the nurse's teaching? correct answers Cell membranes are impermeable to all but lipid-
soluble substances.
A 6-year-old girl with a diagnosis of Marfan syndrome is being assessed at a community health
clinic. Which of the following assessments would be the health care professional's lowest
priority? correct answers Tests of kidney function
A nurse practitioner employed in a hospitalist notices that a patient is experiencing muscle
atrophy following 2 weeks in traction after a motor vehicle accident. Which of the following
factors has most likely contributed to the atrophy of the patient's muscle cells? correct answers A
reduction of skeletal muscle use secondary to the traction treatment
, A nurse practitioner is educating a patient with a recent diagnosis of diabetes about the roles that
glucose and insulin play in the disease pathology and the fact that glucose must enter the cell in
order to provide energy for the patient. The nurse practitioner knows that which of the following
processes allows glucose to enter body cells correct answers Facilitated diffusion
A researcher is involved in the production of insulin through recombinant DNA technology.
Which of the following statements could the researcher best provide as a rationale for her work?
correct answers The gene fragment responsible for insulin production can be isolated and
reproduced.
A student nurse practitioner asks her preceptor about the origins of different tissues, and their
cellular origins during the process of development. Which of the following statements by the
preceptor best describes the process of cell differentiation? correct answers "A fertilized ovum
undergoes a series of divisions, yielding many different cell types."
A 77-year-old male patient with a diagnosis of stomach cancer has been found to have metastases
in his liver. The patient and his family are surprised at this turn of events, stating that they don't
see how he could have developed cancer in his liver. Which of the following facts would underlie
the reply that the care team provides? correct answers The portal circulatory system brings
venous blood from the gastrointestinal tract into the liver.
The nurse practitioner is seeing a client who has an acute exacerbation of Crohn's disease. The
NP recognizes the fact that the disease involves the inflammation and irritation of the intestinal
lining. Which of the following types of tissue is most likely involved in the patient's pathology?
correct answers Simple columnar epithelium
An infant who is four days postpartum has been diagnosed with a single-gene disorder. The
parents of the child have a number of questions about the etiology of the health problem, which
the physician is attempting to address in detail. Which of the following teaching points most
accurately captures an aspect of single-gene congenital disorders? correct answers A particular
defect can be caused by mutations at one of several different loci.