Solutions
A common side effect of the biologic response modifier
neupogen is Correct Answers -Bone pain
-Osteoalthralgia
Neupogen, or Filgrastim, is a granulocyte colony-stimulating
factor (G-CSF) and works by stimulating the bone marrow to
increase the production of neutrophils. As a result of this
mechanism, it is common for individuals to experience an achy
pain in their bones.
Aminoglycoside antibiotics are typically reserved for severe
systemic infections due to aerobic, gram negative bacteria (E.
coli, Serratia, Proteus, Klebsiella, and Pseudomonas). Name a
serious toxicity associated with aminoglycoside antibiotics.
Correct Answers -ototoxicity
-nephrotoxicity
Aminoglycoside antibiotics are very renal toxic (nephrotoxicity)
and may lead to irreversible ototoxicity (hearing loss).
Amphotericin B is an intravenous medication used to treat
systemic fungal infections. What common adverse effects do
patients experience with Amphotericin B infusions? Correct
Answers -Fever
-Rigors
-Chills
,-vomiting
-headache
Fever, shaking chills or rigors, vomiting and headache are
commonly experienced in patients taking Amphotericin B.
Patients are usually premedicated with acetaminophen,
antihistamines, and a corticosteroid to help minimize these
effects.
Doxorubicin is an antitumor antibiotic that is used in the
treatment of many different liquid (leukemia, lymphoma) and
solid tumors. Name an adverse event that may occur in an
individual receiving doxorubicin. Correct Answers -
Cardiotoxicity
-Neutropenia
-Pancytopenia
-Low blood counts
-Nausea and vomiting
-Alopecia, hair loss
Doxorubicin may cause cardiotoxicity, low blood counts
(neutropenia, pancytopenia), nausea/vomiting, or alopecia (hair
loss). An electrocardiogram is typically attained prior to starting
treatment with this chemotherapy.
Fluconazole is a newer systemic antifungal medication which
has largely replaced use of Amphotericin B because of
fluconazole's improved safety and tolerability. Fluconazole,
however, has a narrow spectrum of activity and is effective
, against only one type of Candida species. Which species does
fluconazole effectively treat? Correct Answers -albicans
-Candida albicans
Fluconazole (Diflucan) is available in pill form and can also be
administered IV. Candida albicans is the only Candida species
fluconazole can effectively treat. Candida albicans is the most
common organism in vaginal yeast infections and is commonly
used to treat yeast vaginitis.
Hepatitis C infection remains problematic as there is no vaccine
currently available. Untreated hepatitis C infection will lead to
cirrhosis and/or liver cancer. Name a medication which is
currently available in oral formulations for the treatment of
chronic hepatitis C, genotype 1. Correct Answers -velpatasvir
sofosbuvir
-ledipasvir sofosbuvir
-ledipasvir sofosbuvir
-elbasvir grazoprevir
Velpatasvir sofosbuvir (Epclusa), ledipasvir sofosbuvir
(Harvoni), ledipasvir sofosbuvir (Mavyret), and elbasvir
grazoprevir (Zepatier) are all FDA approved for treatment of
chronic hepatitis C genotype 1 infection.
Immune globulins represent which type of immunity? Correct
Answers -Passive