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MOLECULAR BIOLOGY OF THE CELL 6TH EDITION
ALBERTS WITH RATIONALES (CHAPTER 1-24) FOR
2025-2026
Molecular Biology of the Cell 6th Edition Alberts
Molecular Biology of the Cell 6th Edition Alberts
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Study Guide - Molecular Biology of the Cell 6th Edition Alberts with rationales (Chapter 1-24) FOR 2025-2026 - Page 1
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TABLE OF CONTENTS
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1. Important Terms and Definitions resources
2. Study Questions and Answers
3. study guide / test bank
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1. ('What is caspase?', 'Protease that executes apoptosis. Rationale: Cleaves key cellular proteins.')
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2. ('What is necroptosis?', 'Programmed necrosis. Rationale: Backup cell death pathway.')
3. ('What is the Warburg effect?', 'Cancer cells rely on glycolysis even in oxygen. Rationale:
Supports biosynthesis and growth.')
4. ('What is senescence?', 'Permanent cell cycle arrest. Rationale: Prevents damaged cells from
proliferating.')
5. ('What is the Hayflick limit?', 'Finite number of cell divisions. Rationale: Due to telomere
shortening.')
6. ('What is the central dogma of molecular biology?', 'DNA → RNA → Protein; describes the flow of
genetic information.')
7. ('What are nucleosomes composed of?', 'DNA wrapped around histone proteins, serving as the
fundamental unit of chromatin.')
8. ('Why are histone modifications important?', 'They regulate chromatin structure and gene
expression by recruiting proteins.')
9. ('What is the difference between euchromatin and heterochromatin?', 'Euchromatin is
transcriptionally active and less condensed; heterochromatin is transcriptionally inactive and highly
condensed.')
transcription factors.')
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10. ('What are enhancer sequences?', 'DNA elements that increase transcription by binding
11. ('What is RNA interference (RNAi)?', 'A mechanism where small RNAs degrade or inhibit
translation of specific mRNAs.')
12. ('Why is alternative splicing important?', 'It allows one gene to produce multiple protein
isoforms, increasing proteome diversity.')
13. ('What is the function of tRNA?', 'Transfers amino acids to ribosomes during protein synthesis.')
14. ('What is the role of ribosomal RNA (rRNA)?', 'Forms structural and catalytic components of
ribosomes.')
15. ('What is the function of the Golgi apparatus?', 'Modifies, sorts, and packages proteins and lipids
for secretion or delivery to organelles.')
16. ('What is the purpose of the endoplasmic reticulum (ER)?', 'Rough ER synthesizes proteins;
smooth ER synthesizes lipids and detoxifies molecules.')
17. ('What is the function of signal peptides?', 'They direct proteins to their correct cellular
compartments.')
18. ('What is the purpose of chaperone proteins?', 'Assist in proper protein folding and prevent
aggregation.')
19. ('What is ubiquitination?', 'A post-translational modification marking proteins for degradation by
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the proteasome.')
20. ('What is the difference between exocytosis and endocytosis?', 'Exocytosis exports materials
out of the cell; endocytosis imports materials into the cell.')
21. ('What are tight junctions?', 'Specialized connections that prevent leakage between epithelial
cells.')
Study Guide - Molecular Biology of the Cell 6th Edition Alberts with rationales (Chapter 1-24) FOR 2025-2026 - Page 3