UNE Biochemistry Final
UNE Biochemistry Final Exam with
Questions and Answers Latest
Question 1
A comatose infant is brought to the ER. In the course of the examination, plasma
ammonia was found to be elevated 20-fold over normal values. Urine orotic acid and
uracil were both greater than normal. A defect of which of the following enzymes is
the most likely diagnosis?
N-acetyl glutamate synthetase
Carbamoyl phosphate synthetase I
Carbamoyl phosphate synthetase II
Ornithine transcarbamylase
Phosphoribosyl pyrophosphate synthetase (PRPP Synthetase)
Correct Answer
Ornithine transcarbamylase
Question 2
A precipitating factor for the ketonemia associated with ketogenic diets, starvation,
and untreated type 1 diabetes is:
Hypoinsulinemia
High-fat diet
Defects in the enzymes of β-oxidation
Hyperglycemia
Correct Answer
Hypoinsulinemia
Page 1 of 81
, UNE Biochemistry Final
Question 3
An 11-year-old female is brought to the emergency department by her parent. They
report she has recently been very thirsty and needs to make frequent trips to the
bathroom. Physical examination revealed a thin girl in the 30th percentile for height
and weight. A rapid dipstick test revealed glucose in her urine. Evaluation of this girl's
blood would reveal decreased levels of which of the following compounds or
hormones?
Glutamine
Fatty acids
Glucose
Insulin
Ketones
Correct Answer
Insulin
Question 4
Which of the following shuttle systems is necessary for the oxidation of long-chain
fatty acids?
Glycerol-3-Phosphate
Malate-Aspartate
Carnitine
Citrate
Correct Answer
Carnitine
Question 5
When citrate is shuttled out of the mitochondria for fatty acid synthesis, the initial
reaction by citrate lyase generates which of the following products?
Pyruvate and malate
Acetyl-CoA and oxaloacetate
Citrate and oxaloacetate
Acetyl-CoA and citrate
Correct Answer
Acetyl-CoA and oxaloacetate
Page 2 of 81
, UNE Biochemistry Final
Question 6
Fatty acid synthase is a multimeric enzyme complex. Which of the following subunits
contains pantothenic acid as a cofactor?
Ketoacyl synthase
Enoyl reductase
Acyl carrier protein (ACP)
Thioesterase
Correct Answer
Acyl carrier protein (ACP)
Question 7
High carbohydrate diets can increase serum triglyceride levels in some individuals.
This is probably due to an increase in the synthesis of:
HDL
Chylomicrons
LDL
VLDL
Correct Answer
VLDL
Question 8
Your patient presents with a deficiency of the enzyme that catalyzes synthesis of N-
acetylglutamate (NAGs). Which of the following would be a consequence of this
deficiency in the patient?
Increased fatty acids in the blood
Increased amino acids in the blood
Decreased excretion of uric acid
Increased glucose in the blood
Correct Answer
Increased amino acids in the blood
Page 3 of 81
, UNE Biochemistry Final
Question 9
Dietary cholesterol is primarily transported in the body by which of the following
lipoproteins?
LDL
Chylomicron
VLDL
HDL
Correct Answer
Chylomicron
Question 10
The cellular uptake of LDL increases intracellular cholesterol levels. This has which of
the following impacts on de novo cholesterol synthesis?
Increases degradation of HMG-CoA reductase
Increases activation of SREBP
Increases dephosphorylation of HMG-CoA reductase
Increases activity of HMG-CoA reductase
Correct Answer
Increases degradation of HMG-CoA reductase
Question 11
Secondary bile salts are generated by bacterial modification of primary bile salts in
the intestinal lumen. These modifications have which of the following impacts on bile
salt solubility?
Correct Answer
Decrease solubility
Page 4 of 81
UNE Biochemistry Final Exam with
Questions and Answers Latest
Question 1
A comatose infant is brought to the ER. In the course of the examination, plasma
ammonia was found to be elevated 20-fold over normal values. Urine orotic acid and
uracil were both greater than normal. A defect of which of the following enzymes is
the most likely diagnosis?
N-acetyl glutamate synthetase
Carbamoyl phosphate synthetase I
Carbamoyl phosphate synthetase II
Ornithine transcarbamylase
Phosphoribosyl pyrophosphate synthetase (PRPP Synthetase)
Correct Answer
Ornithine transcarbamylase
Question 2
A precipitating factor for the ketonemia associated with ketogenic diets, starvation,
and untreated type 1 diabetes is:
Hypoinsulinemia
High-fat diet
Defects in the enzymes of β-oxidation
Hyperglycemia
Correct Answer
Hypoinsulinemia
Page 1 of 81
, UNE Biochemistry Final
Question 3
An 11-year-old female is brought to the emergency department by her parent. They
report she has recently been very thirsty and needs to make frequent trips to the
bathroom. Physical examination revealed a thin girl in the 30th percentile for height
and weight. A rapid dipstick test revealed glucose in her urine. Evaluation of this girl's
blood would reveal decreased levels of which of the following compounds or
hormones?
Glutamine
Fatty acids
Glucose
Insulin
Ketones
Correct Answer
Insulin
Question 4
Which of the following shuttle systems is necessary for the oxidation of long-chain
fatty acids?
Glycerol-3-Phosphate
Malate-Aspartate
Carnitine
Citrate
Correct Answer
Carnitine
Question 5
When citrate is shuttled out of the mitochondria for fatty acid synthesis, the initial
reaction by citrate lyase generates which of the following products?
Pyruvate and malate
Acetyl-CoA and oxaloacetate
Citrate and oxaloacetate
Acetyl-CoA and citrate
Correct Answer
Acetyl-CoA and oxaloacetate
Page 2 of 81
, UNE Biochemistry Final
Question 6
Fatty acid synthase is a multimeric enzyme complex. Which of the following subunits
contains pantothenic acid as a cofactor?
Ketoacyl synthase
Enoyl reductase
Acyl carrier protein (ACP)
Thioesterase
Correct Answer
Acyl carrier protein (ACP)
Question 7
High carbohydrate diets can increase serum triglyceride levels in some individuals.
This is probably due to an increase in the synthesis of:
HDL
Chylomicrons
LDL
VLDL
Correct Answer
VLDL
Question 8
Your patient presents with a deficiency of the enzyme that catalyzes synthesis of N-
acetylglutamate (NAGs). Which of the following would be a consequence of this
deficiency in the patient?
Increased fatty acids in the blood
Increased amino acids in the blood
Decreased excretion of uric acid
Increased glucose in the blood
Correct Answer
Increased amino acids in the blood
Page 3 of 81
, UNE Biochemistry Final
Question 9
Dietary cholesterol is primarily transported in the body by which of the following
lipoproteins?
LDL
Chylomicron
VLDL
HDL
Correct Answer
Chylomicron
Question 10
The cellular uptake of LDL increases intracellular cholesterol levels. This has which of
the following impacts on de novo cholesterol synthesis?
Increases degradation of HMG-CoA reductase
Increases activation of SREBP
Increases dephosphorylation of HMG-CoA reductase
Increases activity of HMG-CoA reductase
Correct Answer
Increases degradation of HMG-CoA reductase
Question 11
Secondary bile salts are generated by bacterial modification of primary bile salts in
the intestinal lumen. These modifications have which of the following impacts on bile
salt solubility?
Correct Answer
Decrease solubility
Page 4 of 81
